A5021934641- Pluripotent Stem Cells Research
- Retinal Development and Disorders
- Breast Cancer Treatment Studies
- Cell Adhesion Molecules Research
- Renal and related cancers
- RNA Interference and Gene Delivery
- Liver Disease Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Hematological disorders and diagnostics
- Infectious Aortic and Vascular Conditions
- Biomedical Ethics and Regulation
- Cancer, Hypoxia, and Metabolism
- Hepatitis B Virus Studies
- Neuroethics, Human Enhancement, Biomedical Innovations
- Lung Cancer Diagnosis and Treatment
- CRISPR and Genetic Engineering
- Hepatitis C virus research
- Congenital heart defects research
- Radiomics and Machine Learning in Medical Imaging
- Angiogenesis and VEGF in Cancer
- CAR-T cell therapy research
- Photochromic and Fluorescence Chemistry
- Reproductive Biology and Fertility
- Advanced biosensing and bioanalysis techniques
Center of Regenerative Medicine in Barcelona
2010-2017
Baylor Scott & White Medical Center - Temple
2017
Beaumont Hospital, Royal Oak
2016
Inserm
2009
Hospital Universitario de La Princesa
2009
Universitat de Barcelona
2004
The low number of postnatal endothelial progenitor cells (EPC) in the circulation limits their therapeutic application cardiovascular medicine. Processed lipoaspirate (PLA) differentiate into osteoid, adipose, muscle, and cartilaginous cells. This study examines potential PLA as a source EPCs.PLA obtained from human lipoaspirates were cultured for 1 week serum-depleted medium to form three-dimensional cell clusters (3DCC). phenotype 3DCC-derived was assessed by immunofluorescence staining...
Multiple sclerosis (MS) is considered a chronic autoimmune disease of the central nervous system that leads to gliosis, demyelination, axonal damage and neuronal death. The MS aetiology unknown, though polymorphism TNFRSF1A gene, rs1800693, known confer an increased risk for MS. Using retroviral delivery reprogramming transgenes, we generated six patient-specific iPSC lines with two distinct genotypes, CC or TT, rs1800693. had normal karyotype, expressed pluripotency genes differentiated...
Skin biopsies were obtained from two male patients with X-linked Alport syndrome (XLAS) hemizygous COL4A5 mutations in exon 41 or 46. Dermal fibroblasts extracted and reprogrammed by nucleofection episomal plasmids carrying OCT3/4, SOX2, KLF4 LIN28, L-MYC p53 shRNA. The generated induced Pluripotent Stem Cell (iPSC) lines AS-FiPS2-Ep6F-28 AS-FiPS3-Ep6F-9 free of genomically integrated reprogramming genes, had the specific mutations, a stable karyotype, expressed pluripotency markers embryoid...
A skin biopsy was obtained from a 25-year-old female patient with autosomal recessive Alport syndrome (ARAS) the homozygous COL4A3 mutation c.345delG, p.(P166Lfs*37). Dermal fibroblasts were derived and reprogrammed by nucleofection episomal plasmids carrying OCT3/4, SOX2, KLF4 LIN28, L-MYC p53shRNA. The generated induced Pluripotent Stem Cell (iPSC) clone AS FiPS1 Ep6F-2 free of genomically integrated reprogramming genes, had specific mutation, stable karyotype, expressed pluripotency...
794 Background: Inflammation has a critical role in tumor genesis and progression of cancer. The neutrophil to lymphocyte ratio (NLR) is an indication balance between the immune systems pro defense mechanism against Elevated NLR interest many cancers, including colon Although surgery mainstay treatment for early stage cancer, adjuvant chemotherapy II cancer remained debatable. We proposed study impact patients with identify high risk who would benefit from chemotherapy. Methods: Three...
565 Background: While radiation portals are tailored to a patient’s unique anatomy and the selection of systemic agents routinely employs biomarker data, radiotherapy based on tumor biology is not utilized in breast cancer. The purpose this study was identify which genetic markers possible predictors for local recurrence as surrogate response. Methods: We identified 200 patients who received Selected included: Androgen receptor (AR), Hypoxia Inducible Factor 1-α (HIF-1),...
e15146 Background: Inflammation has a critical role in tumor genesis and progression of cancer. The neutrophil to lymphocyte ratio (NLR) is an indication balance between the immune systems pro defense mechanism against Elevated NLR interest many cancers, including colon Although surgery mainstay treatment for early stage cancer, adjuvant chemotherapy II cancer remained debatable. We proposed study impact patients with identify high risk who would benefit from chemotherapy. Methods: Three...