A5011326944- Pancreatic function and diabetes
- Tissue Engineering and Regenerative Medicine
- Diabetes and associated disorders
- Electrospun Nanofibers in Biomedical Applications
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Pancreatitis Pathology and Treatment
Vita-Salute San Raffaele University
2021-2025
IRCCS Ospedale San Raffaele
2021-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2023
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2023
Abstract Intrahepatic islet transplantation is the standard cell therapy for β replacement. However, shortage of organ donors and an unsatisfactory engraftment limit its application to a selected patients with type 1 diabetes. There urgent need identify alternative strategies based on unlimited source insulin producing cells innovative scaffolds foster interaction integration orchestrate physiological endocrine function. We previously proposed use decellularized lung as scaffold replacement...
The engraftment of transplanted islets depends on the rapid establishment a novel vascular network. present study evaluated effects cord blood-derived blood outgrowth endothelial cells (BOECs) viability neonatal porcine (NPIs) and post-transplant outcome grafted NPIs. Dispersed NPIs human BOECs were reaggregated microwell cell culture plates tested for their anti-apoptotic pro-angiogenic capacity by qRT-PCR immunohistochemistry. in vivo functionality was analyzed after transplantation into...