A5103221636- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Multiple Myeloma Research and Treatments
- Tracheal and airway disorders
- T-cell and B-cell Immunology
- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Airway Management and Intubation Techniques
- Chemokine receptors and signaling
- CAR-T cell therapy research
- Transplantation: Methods and Outcomes
- RNA Interference and Gene Delivery
- Hematopoietic Stem Cell Transplantation
- Intensive Care Unit Cognitive Disorders
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Ear and Head Tumors
- Adrenal and Paraganglionic Tumors
- Cardiac Structural Anomalies and Repair
- Cancer and Skin Lesions
- IL-33, ST2, and ILC Pathways
- Chronic Lymphocytic Leukemia Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Perfectionism, Procrastination, Anxiety Studies
CHU Dinant Godinne UCL Namur
2024
Ghent University Hospital
2023
UCLouvain
2021
Cliniques Universitaires Saint-Luc
2017-2019
University Medical Center Hamburg-Eppendorf
2008-2013
University Cancer Center Hamburg
2009-2013
Universität Hamburg
2008-2013
Universitätskinderklinik
2006
Philipps University of Marburg
2003-2005
University Hospital Schleswig-Holstein
2004
Abstract Cancer‐testis antigens (CTA) represent attractive targets for tumor immunotherapy. However, a broad picture of CTA expression in acute myeloid leukemia (AML) is missing. was analyzed normal bone marrow (BM) as well AML cell lines before and after treatment with demethylating agents and/or histone acetylase inhibitors. Presence selected strictly tumor‐restricted then determined samples patients therapy. Screening the 20 CTA, we identified six genes (MAGE‐A3, PRAME, ROPN1, SCP‐1,...
Background Multiple myeloma is a life-threatening disease and despite the introduction of stem cell transplantation novel agents such as thalidomide, lenalidomide, bortezomib most patients will relapse develop chemoresistant disease. Therefore, alternative therapeutic modes for are needed cancer-testis antigens MAGE-C1/CT7 MAGE-A3 have been suggested to represent class tumor-specific proteins particularly suited targeted immunotherapies. Surprisingly, biological role genes in remains poorly...
Neuromuscular block recovery was evaluated using high-frequency tetanic ulnar nerve simulations compared to normalized train-of-four (NTOF) in anesthetized patients. Under intravenous general anesthesia, we rocuronium-induced neuromuscular 5 s 100- and 200-Hz stimulations via isometric mechanomyography acceleromyographic NTOF 20 consenting The primary outcome the comparison by Student's t-tests of fade ratios (residual force at end contraction / maximal reached during s) before rocuronium...
To date, multiple myeloma remains an incurable malignancy due to the persistence of minimal residual disease in bone marrow. In this setting, monoclonal antibodies against myeloma-specific cell surface antigens represent a promising therapeutic approach, which is however hampered by lack appropriate target structures expressed across all pathogenic populations. We, therefore, investigated functionally relevant immunoreceptors specifically associated with cells as well their clonogenic...
BackgroundMultiple myeloma is a malignancy characterized by the expansion of plasma cell clone that localizes to human bone marrow. Myeloma cells and marrow stromal produce soluble factors promote survival progression multiple myeloma. Interleukin 16 (IL-16) involved in regulating migration proliferation normal leukocytes. However, role IL-16 cancers, including myeloma, unclear.
Airway stenting offers good palliation and improves the quality of life in patients with inoperable bronchotracheal stenosis. However, some cases, management can be life-threatening. Hence, a strategy for maintaining oxygenation hemodynamic stability should anticipated to avoid critical situations. Herein, we report use extracorporeal membrane (ECMO) secure facilitate interventions.We retrospectively reviewed all who underwent rigid bronchoscopy under ECMO support at CHU UCL Namur hospital...
Patients with gastric cancer benefit from perioperative chemotherapy, however, treatment is toxic and many patients will relapse. The trifunctional antibody catumaxomab targets EpCAM on tumor cells, CD3 T the Fcγ-receptor of antigen-presenting cells. While in Europe approved for treating malignant ascites, it has not been investigated setting its exact immunological mode action unclear.In our study, received neoadjuvant platinum-based one intraoperative application catumaxomab, 4...
Acute psychological stress has primarily been investigated regarding its effects on conventional lymphocytes such as natural killer (NK) cells and CD4(+) CD8(+) T cells. However, it might be important to focus more "specialized" lymphocyte subsets, playing a role, for instance, in allergic conditions autoimmunity, identify links between stress, the immune system somatic diseases. Using flow cytometry we determined frequencies of circulating helper (Th)1-type (CD226(+)) Th2-type (CRTH2(+))...
Few clinical studies have assessed gamma-hydroxybutyrate and chlorprothixene/phenobarbital sedation in children. This prospective trial compared the two regimes children, particular concerning differences recovery time.28 pediatric oncology patients undergoing elective MRI at a university hospital were randomly assigned to either receive or sedation. Time induce deep (Ramsay score of 5) time, incidence failure sedation, frequency side effects, need for therapeutic interventions, number...
Adoptive transfer of T lymphocytes equipped with tumor-antigen specific T-cell receptors (TCRs) represents a promising strategy in cancer immunotherapy, but the approach remains technically demanding. Using influenza virus (Flu)-specific responses as model system we compared different methods for generation clones and isolation antigen-specific TCRs. Altogether, generated 12 CD8(+) reacting to Flu matrix protein (Flu-M) 6 CD4(+) nucleoprotein (Flu-NP) from 4 healthy donors....
Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
A straight silicone stent can be used to treat proximal benign tracheal stenosis in non-surgical candidates. However, migration is a common complication when placed at particular location and lead major complications. This case series of laryngotracheal reports fixation method for stents the subglottic trachea (Stage 3 McCaffrey classification).
Abstract Background Physiologic narrowing of the central airway occurs during expiration. Conditions in which this becomes excessive are referred to as expiratory collapse. Expiratory collapse is usually managed by applying positive pressure airways, acts a pneumatic stent. The particularity case reported here included patient’s left main bronchus being permeable spontaneous breathing but collapsing general anaesthesia, despite ventilation and end-expiratory pressure. Case presentation We...
Der solide-pseudopapilläre Pankreastumor stellt eine sehr seltene Neoplasie dar, die vorwiegend Mädchen und junge Frauen betrifft. Aufgrund seines biologischen Verhaltens ist er als gutartig einzustufen. Lokale Infiltration Metastasierung sind ebenso wie Rezidive selten. Ursprung der Tumorzelle des soliden-pseudopapillären Tumors Pankreas nicht geklärt [4] [6]. 1996 wurde erstmals in WHO-Klassifikation exokrinen Pankreastumoren aufgenommen [3]. Nach Erstbeschreiberin wird diese Tumorentität...
Introduction: Hemangiomas are the most common tumors of infancy. present at birth in up to 2,5% and more than 10% caucasic population show hemangiomas their first year life. Hemangiomas, benign vascular lesions usually a tendency grow rapidly during 8–12 months life, followed by an involution phase that could take several years. Most do not require specific treatment because high rate spontaneous regression. However, small number therapy including endangering vision, oral intake organ functions.