A5035872054- Photoreceptor and optogenetics research
- Receptor Mechanisms and Signaling
- Hearing, Cochlea, Tinnitus, Genetics
- Nicotinic Acetylcholine Receptors Study
- Hormonal Regulation and Hypertension
- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Cell Adhesion Molecules Research
- Adipose Tissue and Metabolism
- Ion Transport and Channel Regulation
- Marine animal studies overview
- Bone health and treatments
- Lipid Membrane Structure and Behavior
- Cancer-related molecular mechanisms research
- Neural dynamics and brain function
- MicroRNA in disease regulation
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Regulation of Appetite and Obesity
- Adrenal and Paraganglionic Tumors
- Sleep and Wakefulness Research
- Bone Metabolism and Diseases
- Congenital heart defects research
- Neuroendocrine regulation and behavior
- Developmental Biology and Gene Regulation
Howard Hughes Medical Institute
2011-2025
University of California, San Diego
2025
Janelia Research Campus
2011-2021
Helix (United States)
2011-2016
University of Virginia
2007-2008
University of Pennsylvania
2005
St Bartholomew's Hospital
1982
Abstract Osteoclasts were incubated on a glass or plastic substrate and the effect of calcitonin (CT) their behaviour was observed. Before exposure to CT osteoclasts actively motile, cytoplasm advancing behind broad pseudopodial (lamellipodial) processes which showed intense ruflling activity. caused cessation lamellipodial activity within minutes, followed by gradual fragmentation retraction lamellipodia. Complete osteoclast quiescence regularly induced concentrations above 50 pg/ml, lesser...
Engineered ion channels enable manipulation of cellular function by selective chemical control ionic conductance.
Improved agonists for chemogenetics Targeting ligand-responsive receptors to specific groups of cells, a strategy known as chemogenetics, is powerful tool in many neurological applications. There increasing interest extending these tools human treatment. Magnus et al. designed chemogenetic ion channels that improve currently available systems and are activated by the clinically used antismoking drug varenicline. They engineered ligand-binding domain less responsive endogenous signals...
The efficacy of fast synaptic inhibition is critically dependent on the accumulation GABA A receptors at inhibitory synapses, a process that remains poorly understood. Here, we examined dynamics cell surface using receptor subunits modified with N-terminal extracellular ecliptic pHluorin reporters. In hippocampal neurons, incorporating pHluorin-tagged were found to be clustered sites and also expressed as diffuse extrasynaptic staining. By combining FRAP (fluorescence recovery after...
Abstract Debilitating hearing and balance deficits often arise through damage to the inner ear's hair cells. For humans other mammals, such are permanent, but nonmammalian vertebrates can quickly recover their innate capacity regenerate The biological basis for this difference has remained unknown, recent investigations in wounded epithelia have shown that proliferation follows cellular spreading at sites of injury. As mammalian ears mature during first weeks after birth, declines sharply....
BACKGROUND: Primary aldosteronism is the most common form of secondary hypertension. The frequent genetic cause aldosterone-producing adenomas somatic mutations in potassium channel KCNJ5. They affect ion selectivity channel, with sodium influx leading to cell membrane depolarization and activation calcium signaling, major trigger for aldosterone biosynthesis. METHODS: To investigate how KCNJ5 lead development adenomas, we established an adrenocortical model which entry into cells can be...
Abstract Hair cell losses can produce severe hearing and balance deficits in mammals nonmammals alike, but recover after epithelial supporting cells divide give rise to replacement hair cells. Here, we describe cellular changes that appear underlie the permanence of mammalian vestibular organs. In sensory epithelia isolated from utricles embryonic day 18 (E18) mice, readily spread proliferated, spreading proliferation were infrequent postnatal 6 (P6) mice. Cellular dependent on α6 integrin,...
The Journal of Comparative Neurology, Volume 511, Issue 3, pages 396-414, 20 November 2008 In the above-referenced article, author Joseph Burns should have been listed as C. Burns.
Abstract Primary aldosteronism (PA) is the most frequent form of secondary arterial hypertension. The identification germline or somatic mutations in different genes coding for ion channels (KCNJ5, CACNA1D, CACNA1H and CLCN2) ATPases (ATP1A1 ATP2B3) defines PA as a channelopathy. These promote increased intracellular calcium concentrations activation signaling, main trigger aldosterone biosynthesis. aim our study was to elucidate mechanisms underlying development by modulating signaling...