A5063542194- Rheumatoid Arthritis Research and Therapies
- Data-Driven Disease Surveillance
- Spatial and Panel Data Analysis
- Pain Mechanisms and Treatments
- Breast Cancer Treatment Studies
- Migraine and Headache Studies
- Neuropeptides and Animal Physiology
- Systemic Lupus Erythematosus Research
- Pharmacological Effects of Natural Compounds
- Neuroscience and Neuropharmacology Research
- Neurological diseases and metabolism
- Inflammatory mediators and NSAID effects
- Healthcare innovation and challenges
- Nitric Oxide and Endothelin Effects
- Geographic Information Systems Studies
- Osteoarthritis Treatment and Mechanisms
- Cerebrovascular and genetic disorders
- Neurological Disease Mechanisms and Treatments
- HER2/EGFR in Cancer Research
- Molecular Biology Techniques and Applications
- Hepatitis C virus research
- Breast Lesions and Carcinomas
- Urban Transport and Accessibility
- Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
Grünenthal Group (Germany)
2015-2022
University of Sheffield
2008-2016
University of Otago
2016
AstraZeneca (United Kingdom)
2004-2012
Roche (Switzerland)
2011-2012
University of Huddersfield
2011
East Surrey Hospital
2010
Frimley Park Hospital
2010
Weatherford College
2008
Peninsula College of Medicine and Dentistry
2008
Despite the recent focus on sexual behaviour and AIDs, there are almost no data prevalence of dysfunction within primary care settings.One hundred seventy patients attending a general practice participated in questionnaire survey characteristics problems. The detection rate practitioners (GPs) indicators patient notes were also investigated.Thirty five per cent men (n = 22) reported some form specific dysfunction: premature ejaculation was identified 31 men; 17 experienced erectile...
Intra-articular injection of mono-iodoacetate (MIA) in the rat knee joint induces a histopathology with similarities to osteoarthritis (OA). Typically, synovitis (days 1–3) is observed followed by thinning articular cartilage and subsequent lesion subchondral bone at days 8–14 onwards. Behaviourally, weight-bearing asymmetry observed, which sensitive anti-inflammatory pharmacology early but not later 14+) time points. As densely innervated, an intriguing possibility that focal pathology may...
Innate responses against spontaneous pain are proposed to improve the predictive validity of preclinical analgesia models. Therefore, development and validation novel readouts is necessary. To investigate whether innate rodent burrowing a useful alternative behavioural readout for assessment analgesic efficacy, complete Freund's adjuvant (CFA)-induced model sub-chronic inflammation was used compare effects naproxen, ibuprofen pregabalin in weight-bearing (WB), open-field (OF) assays.Male...
Rituximab significantly improves the signs and symptoms of rheumatoid arthritis (RA) slows progression joint damage. The aim this study was to identify clinical characteristics biomarkers that patients with RA in whom benefit rituximab may be enhanced.The group comprised 1,008 from 2 independent randomized placebo-controlled phase III trials (REFLEX [Randomized Evaluation Long-Term Efficacy Rheumatoid Arthritis] SERENE [Study Evaluating Rituximab's Methotrexate Inadequate Responders]). A...
Abstract Background Burrowing is an evolutionarily conserved behaviour in rodents. This study validates a refined burrowing paradigm (requiring reduced number of animals) rat model sub‐chronic knee joint inflammation and evaluates its sensitivity specificity for analgesic drugs. Methods Knee rats was induced by intra‐articular injection with complete F reund's adjuvant ( CFA ). performance assessed at baseline without drugs, ‐naive ‐injected animals following administration the drugs...
ABSTRACT Initial adhesion of fungi to plasticized polyvinyl chloride (pPVC) may determine subsequent colonization and biodeterioration processes. The deteriogenic fungus Aureobasidium pullulans was used investigate the physicochemical nature both unplasticized PVC (uPVC) pPVC containing plasticizers dioctyl phthalate (DOP) adipate (DOA). A quantitative assay using image analysis identified fundamental differences in mechanism A. blastospores these substrata. Adhesion greater than that uPVC...
More evidence is needed on the potential role of 'booster' interventions in maintenance increases physical activity levels after a brief intervention relatively sedentary populations. To determine whether objectively measured activity, 6 months intervention, increased those receiving consultations delivered motivational interviewing (MI) style, either face to or by telephone. Three-arm, parallel-group, pragmatic, superiority randomised controlled trial with nested qualitative research...