A5027399223- Fibroblast Growth Factor Research
- Neonatal Respiratory Health Research
- Prenatal Substance Exposure Effects
- Pregnancy and preeclampsia studies
- Epigenetics and DNA Methylation
- Wnt/β-catenin signaling in development and cancer
- Reproductive Physiology in Livestock
- Birth, Development, and Health
- Proteoglycans and glycosaminoglycans research
University of Kansas Medical Center
2020-2024
The ovarian stroma, the microenvironment in which female gametes grow and mature, becomes inflamed fibrotic with age. Hyaluronan is a major component of extracellular matrix (ECM), other aging tissues, accumulation low molecular weight (LMW) hyaluronan fragments can drive inflammation. Thus, we hypothesized that LMW contribute to reproductive by stimulating an inflammatory response stroma impairing gamete quality. To test this hypothesis, isolated mouse stromal cells or secondary stage...
Trophoblast stem (TS) cells have the unique capacity to differentiate into specialized cell types, including extravillous trophoblast (EVT) cells. EVT invade and transform uterus where they act remodel vasculature facilitating redirection of maternal nutrients developing fetus. Disruptions in development function are at core pregnancy-related disease. WNT-activated signal transduction is a conserved regulator morphogenesis many organ systems, placenta. In human TS cells, activation canonical...
Trophoblast stem (TS) cells have the unique capacity to differentiate into specialized cell types, including extravillous trophoblast (EVT) cells. EVT invade and transform uterus where they act remodel vasculature facilitating redirection of maternal nutrients developing fetus. Disruptions in development function are at core pregnancy-related disease. WNT-activated signal transduction is a conserved regulator morphogenesis many organ systems, placenta. In human TS cells, activation canonical...