A5001661060- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Estrogen and related hormone effects
- Pregnancy and preeclampsia studies
- Neonatal Respiratory Health Research
- Epigenetics and DNA Methylation
- Pregnancy-related medical research
- Reproductive Physiology in Livestock
- Prenatal Substance Exposure Effects
- Fibroblast Growth Factor Research
- Birth, Development, and Health
- Hedgehog Signaling Pathway Studies
- Cancer-related Molecular Pathways
- Per- and polyfluoroalkyl substances research
- Synthesis of Organic Compounds
- Effects and risks of endocrine disrupting chemicals
- Phytoestrogen effects and research
- NF-κB Signaling Pathways
- Adenosine and Purinergic Signaling
- Uterine Myomas and Treatments
- Gestational Trophoblastic Disease Studies
- Sperm and Testicular Function
- Toxic Organic Pollutants Impact
- Cancer Treatment and Pharmacology
- Reproductive Biology and Fertility
University of Kansas Medical Center
2021-2024
Central Drug Research Institute
2014-2021
Academy of Scientific and Innovative Research
2018-2021
University of Lucknow
2015
Our earlier studies have demonstrated the cyclic variation and also altered expression of sorcin in endometrium during early-to-mid-secretory phase transition women with unexplained infertility. The current study was undertaken to establish functional role endometrial receptivity mice. Results indicated that highly expressed window implantation mice blockage caused significant reduction number implanted blastocyst. markers (i.e.Integrin β3, HBEGF, IGFBP1, WNT4 Cyclin E)) were found be...
Embryo implantation and decidualization are critical events that occur during early pregnancy. Decidualization is synchronized by the crosstalk of progesterone cAMP signaling pathway. Previously, we confirmed role TPPP3 embryo in mice, but underlying mechanism has not yet been understood. The current study was aimed to investigate vivo vitro. For experiments, decidual reaction artificially induced uteri BALB/c mice. found be highly expressed decidualization, whereas receiving siRNA,...
Trophoblast stem (TS) cells have the unique capacity to differentiate into specialized cell types, including extravillous trophoblast (EVT) cells. EVT invade and transform uterus where they act remodel vasculature facilitating redirection of maternal nutrients developing fetus. Disruptions in development function are at core pregnancy-related disease. WNT-activated signal transduction is a conserved regulator morphogenesis many organ systems, placenta. In human TS cells, activation canonical...
Endometrial hyperplasia is an estrogen-dependent disease and the most frequent precursor of endometrial cancer, diagnosed in pre- peri-menopausal women.
The present study was undertaken to explore the functional involvement of Hh signaling and its regulatory mechanism in endometrial hyperplasia. Differential expression molecules i.e., Ihh, Shh, Gli1 or Gsk3β observed hyperplasial (EH) cells as compared normal cells. Estradiol induced attenuated whereas anti-estrogen (K1) progestin (MPA) suppressed these effects EH Cyclopamine treatment siRNA knockdown growth reduced proliferative markers. also nuclear translocation which by both MPA K1 While...
Trophoblast stem (TS) cells have the unique capacity to differentiate into specialized cell types, including extravillous trophoblast (EVT) cells. EVT invade and transform uterus where they act remodel vasculature facilitating redirection of maternal nutrients developing fetus. Disruptions in development function are at core pregnancy-related disease. WNT-activated signal transduction is a conserved regulator morphogenesis many organ systems, placenta. In human TS cells, activation canonical...
BACKGROUND: The primary interface between mother and fetus, the placenta, serves two critical functions: extraction of nutrients from maternal compartment facilitation nutrient delivery to developing fetus. This system also as a barrier environmental exposures. aryl hydrocarbon receptor (AHR) is an important component barrier. AHR signaling activated by pollutants toxicants that can potentially affect cellular molecular processes, including those controlling trophoblast cell development...
Tubulin polymerization promoting protein 3 (TPPP3) is known to be expressed in the endometrium a cyclic manner, and its functional role physiology of implantation remains unknown. Here we demonstrate novel function TPPP3 during window establishment pregnancy using mouse model. The increased expression β-catenin peri-implantation period, i.e. D5 (receptive phase, 0800 h), was observed as compared that on D1 (nonreceptive h). SiRNATPPP3-mediated knockdown uterine resulted failure inhibited...
Microtubule (MT) dynamics plays a crucial role in fertilization and early embryonic development; however its involvement uterus during embryo implantation remains unclear. Herein, we report the effect of microtubule depolymerization BALB/c mice. Intrauterine treatment with depolymerizing agent nocodazole at pre-implantation phase (D4, 07:00 h) mice resulted into mitigation receptivity markers viz. LIF, HoxA10, Integrin-β3, IHH, WNT4 led to pregnancy failure. MT endometrial epithelial cells...