A5067054198- Virology and Viral Diseases
- Poxvirus research and outbreaks
- Climate variability and models
- Climate change impacts on agriculture
- SARS-CoV-2 and COVID-19 Research
- Hydrology and Drought Analysis
- Synthesis and biological activity
- Mosquito-borne diseases and control
- Animal Virus Infections Studies
- Bioactive Compounds and Antitumor Agents
- Virus-based gene therapy research
- Cancer-related Molecular Pathways
- Viral Infections and Vectors
- Synthesis and Biological Evaluation
- Phytochemical compounds biological activities
- Autophagy in Disease and Therapy
- Traditional and Medicinal Uses of Annonaceae
- Climate Change and Health Impacts
- Natural product bioactivities and synthesis
- Remote Sensing in Agriculture
- Endoplasmic Reticulum Stress and Disease
- Synthesis and bioactivity of alkaloids
- Graphene research and applications
- Cell death mechanisms and regulation
- Estrogen and related hormone effects
Academy of Scientific and Innovative Research
2016-2025
Central Drug Research Institute
2016-2025
University of Lucknow
2015-2023
Homi Bhabha National Institute
2023
Tata Memorial Hospital
2023
Aalto University
2022-2023
Council of Scientific and Industrial Research
2014-2022
India Meteorological Department
2006-2021
Centre for Cancer Biology
2021
Government of India
1973-2019
Abstract α -Solanine is a glycoalkaloid found in species of the nightshade family including potato. It was primarily reported to have toxic effects humans. However, there growing body literature demonstrating vitro and vivo anticancer activity -solanine. Most these studies shown activation apoptosis as underlying mechanism antitumor In this study, we report -solanine potential inducer autophagy, which may act synergistically or parallel with exert its cytotoxic effect. Induction autophagy...
Background . Ahmedabad implemented South Asia’s first heat action plan (HAP) after a 2010 heatwave. This study evaluates the HAP’s impact on all-cause mortality in 2014–2015 relative to 2007–2010 baseline. Methods We analyzed daily maximum temperature ( T max )-mortality relationships before and HAP. estimated rate ratios (RRs) for using distributed lag nonlinear models incidence rates (IRs) HAP warning days, comparing pre- post-HAP periods, calculated (IRRs). number of deaths avoided...
Ferroptosis, a genetically and biochemically distinct form of programmed cell death, is characterised by an iron-dependent accumulation lipid peroxides. Therapy-resistant tumor cells display vulnerability toward ferroptosis. Endoplasmic Reticulum (ER) stress Unfolded Protein Response (UPR) play critical role in cancer to become therapy resistant. Tweaking the balance UPR make susceptible ferroptotic death could be attractive therapeutic strategy. To decipher emerging contribution ER process,...
The anticancer potential of Xylopia aethiopica fruit extract (XAFE), and the mechanism cell death it elicits, was investigated in various lines. Treatment with XAFE led to a dose‐dependent growth inhibition most lines, selective cytotoxicity towards cancer cells particularly human cervical line C‐33A. In this study, apoptosis confirmed by nuclear fragmentation sub‐G 0 /G 1 phase accumulation. cycle arrested at G 2 /M decreased population. A semi‐quantitative gene expression study revealed...