A5103113143- Ubiquitin and proteasome pathways
- Cerebral Palsy and Movement Disorders
- Acute Myeloid Leukemia Research
- Ear Surgery and Otitis Media
- Estrogen and related hormone effects
- Nasal Surgery and Airway Studies
- Retinoids in leukemia and cellular processes
- Head and Neck Cancer Studies
- Botulinum Toxin and Related Neurological Disorders
- Welding Techniques and Residual Stresses
- Head and Neck Surgical Oncology
- Protein Kinase Regulation and GTPase Signaling
- Children's Physical and Motor Development
- Advanced Proteomics Techniques and Applications
- Salivary Gland Tumors Diagnosis and Treatment
- Tracheal and airway disorders
- Non-Destructive Testing Techniques
- Cancer Diagnosis and Treatment
- Hip disorders and treatments
- Stroke Rehabilitation and Recovery
- Thyroid Cancer Diagnosis and Treatment
- Airway Management and Intubation Techniques
- Synthesis and bioactivity of alkaloids
- Congenital Diaphragmatic Hernia Studies
- Nuclear Structure and Function
Institute of Medical Sciences
2014-2024
University of Health Science
2021
University of Health Sciences
2021
Jadavpur University
2016-2021
Tata Memorial Hospital
2013-2020
San Jose State University
2018-2020
Government Medical College, Amritsar
2020
Solid State Physics Laboratory
2020
Central Drug Research Institute
2008-2013
Determining the level of nodal metastases may help decrease extent neck dissections and reduce morbidity.A prospective study in patients with oral cancer was conducted. Each delineated, sent for histopathology, reported level-wise. Incidence overall isolated metastatic nodes at different levels calculated. Logistic regression used to find factors predicting IIB V.Five hundred eighty-three were prospectively evaluated. A total 95.7% occurred I IV. Overall incidence V 3.8% 3.3%, respectively....
Ormeloxifen is a nonsteroidal selective estrogen receptor modulator (SERM) and has been shown to possess anticancer activities in breast uterine cancer. Here, we show that ormeloxifen induces apoptosis dose-dependent manner variety of leukemia cells, more strikingly K562. 2-DE-gel electrophoresis K562 cells induced with showed 57 30% proteins belong cell-cycle pathways, respectively. Our data demonstrate ormeloxifen-induced involves activation extracellular signal-regulated kinases (ERKs)...
CCAAT/enhancer-binding protein alpha (C/EBPα) is an important transcription factor involved in granulocytic differentiation. Here, for the first time we demonstrate that E6-associated (E6AP), E3 ubiquitin ligase targets C/EBPα ubiquitin-mediated proteasome degradation and thereby negatively modulates its functions. Wild-type E6AP promotes dependent of C/EBPα, while catalytically inactive having cysteine replaced with alanine at amino-acid position 843 (E6AP-C843A) rather stabilizes it....
CCAAT/Enhancer Binding Protein Alpha (C/EBPα) is a key transcription factor involved in the adipocyte differentiation. Here for first time we demonstrate that E6AP, an E3 ubiquitin ligase inhibits differentiation 3T3-L1 cells as revealed by reduced lipid staining with oil red. Knock down of E6AP mouse 3T3L1 preadipocytes sufficient to convert them adipocytes independent external hormonal induction. C/EBPα protein level drastically increased deficient while inverse observed when wild type...
Tamoxifen ( T am) is most widely used selective estrogen receptor modulator SERM ) for treatment of hormone‐responsive breast cancer. Despite being regularly in clinical therapy cancer since 1971, the mechanism am action remains largely unclear. In order to gain insights into am‐mediated antibreast actions, we applied 2DE and MS based proteomics approach identify target proteins am. We identified E 6‐associated protein, i.e. 6 AP UBE 3 A among others be regulated by that otherwise...
Nuclear receptor coregulators play an important role in the transcriptional regulation of nuclear receptors. In present study, we aimed to identify estrogen α (ERα) interacting proteins Tamoxifen treated MCF7 cells. Using vitro GST-pull down assay with ERα ligand-binding domain (ERα-LBD) and MS-based proteomics approach identified Profilin1 as a novel protein. contains I/LXX/L/H/I amino acid signature motif required for corepressor interaction ERα. We show that these two physically interact...
<p class="abstract"><strong>Background:</strong> The objectives of the study were <span lang="EN-IN">correlation hearing loss with size and site tympanic membrane perforation. </span></p><p class="abstract"><strong>Methods:</strong> lang="EN-IN">A cross-sectional prospective 100 patients both sex age between 11-60 years perforated was conducted in department Otorhinolaryngology (ENT). Size TM perforation assessed using otoscope...
Dural involvement is an important consideration in assessment of cranial base tumors dictating resectability and prognosis. Preoperative as well intraoperative clues are valuable but not always correct. We evaluated a consecutive series craniofacial resections at our center to correlate radiologically suspected dural vis-à-vis eventual pathology.We conducted retrospective analysis cases skull where potential was considered. recorded the preoperative radiological impression (contrast-enhanced...
Abstract The weld quality is mostly depended on the welding input factors. Welding controlled by appropriately controlling using process factors with sound knowledge base. major influencing Tungsten Inert Gas (TIG) parameters are current, gas flow rate and speed of welding. Controlling these parameters, Duplex Stainless Steel (DSS) joints improved. These optimized to achieve better DSS joints. Here, Principal Component Analysis (PCA) method concept Taguchi’s signal noise ratio (S/N) used...
<p class="abstract"><strong>Background:</strong> Tracheostomy is a life saving procedure, which when performed correctly greatly impacts the final outcome of patient. Although uncommon, fatal complications have been known to occur. The present study was conducted observe incidence early tracheostomy in tertiary care centre.</p><p class="abstract"><strong>Methods:</strong> 100 consecutive patients subjected were enrolled, and data pertaining...
Silicon Carbide (SiC) is a wide bandgap material with unique properties attractive for high power, temperature applications. The presence of defects in the crystal major issue prior device fabrication. These affect performance device. To delineate and identify an easy quick method desirable. In this study delineation n-type 4H-SiC has been carried out by KOH, KOH+NaOH KOH+Na2O2 melts. Variation etch pits size was found at various concentrations NaOH KOH different total etching times melt....
Various efforts have been made to reduce post tonsillectomy pain in children. The present study was undertaken evaluate the efficacy and safety of Ropivacaine post-operative management these children.This is a Randomized control on 140 patients between 4 - 12 years age, whom performed tertiary care centre January 2017 November 2018 using standard dissection snare surgical technique. Postoperatively, were randomized into 2 groups 70 each, receiving tonsillar fossa infiltration with 0.2% or...
To understand the relation of musculoskeletal strength and function to postural stability in ambulatory adults with cerebral palsy (CP) who have already developed muscle atrophy osteoporosis.Two independent group comparison CP those without it.Laboratory study.Thirteen sex (9 women: 4 men), age (21-62y), Gross Motor Function Classification System I-III, 13 sex-, age-, body-weight-matched control participants completed our study (N=26).Not applicable.Bone mineral density (BMD), structural or...