A5006047704- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Cancer Cells and Metastasis
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Chemokine receptors and signaling
- Cancer Genomics and Diagnostics
- Endoplasmic Reticulum Stress and Disease
- Cancer Mechanisms and Therapy
- Immunotherapy and Immune Responses
- Peroxisome Proliferator-Activated Receptors
- Nanoparticle-Based Drug Delivery
- Osteoarthritis Treatment and Mechanisms
- Advanced biosensing and bioanalysis techniques
- Genomics and Chromatin Dynamics
- Prostate Cancer Treatment and Research
- Autophagy in Disease and Therapy
- RNA Interference and Gene Delivery
- Click Chemistry and Applications
- interferon and immune responses
- Mesenchymal stem cell research
- Lymphatic System and Diseases
- Knee injuries and reconstruction techniques
- Ubiquitin and proteasome pathways
Northwestern University
2024-2025
Central Drug Research Institute
2019-2024
Council of Scientific and Industrial Research
2024
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
2024
University of Lucknow
2019
Abstract Emergence of an aggressive androgen receptor (AR)-independent neuroendocrine prostate cancer (NEPC) after androgen-deprivation therapy (ADT) is well-known. Nevertheless, the majority advanced-stage patients, including those with SPINK1-positive subtype, are treated AR-antagonists. Here, we show AR and its corepressor, REST, function as transcriptional-repressors SPINK1 , AR-antagonists alleviate this repression leading to upregulation. Increased SOX2 expression during...
Abstract Triple-Negative Breast Cancer (TNBC) has a poor prognosis and adverse clinical outcomes among all breast cancer subtypes as there is no available targeted therapy. Overexpression of Enhancer zeste homolog 2 (EZH2) been shown to correlate with TNBC’s prognosis, but the contribution EZH2 catalytic (H3K27me3) versus non-catalytic (NC-EZH2) function in TNBC progression remains elusive. We reveal that selective hyper-activation functional over NC-EZH2 alters metastatic landscape fosters...
Ferroptosis, a genetically and biochemically distinct form of programmed cell death, is characterised by an iron-dependent accumulation lipid peroxides. Therapy-resistant tumor cells display vulnerability toward ferroptosis. Endoplasmic Reticulum (ER) stress Unfolded Protein Response (UPR) play critical role in cancer to become therapy resistant. Tweaking the balance UPR make susceptible ferroptotic death could be attractive therapeutic strategy. To decipher emerging contribution ER process,...
The de novo purine synthesis pathway is fundamental for nucleic acid production and cellular energetics, yet the role of mitochondrial metabolism in modulating this process remains underexplored. In many cancers, metabolic reprogramming supports rapid proliferation survival, but specific contributions tricarboxylic (TCA) cycle enzymes to nucleotide biosynthesis are not fully understood. Here, we demonstrate that TCA enzyme succinate dehydrogenase (SDH) essential maintaining optimal normal...
Chemokine receptor CXCR4 overexpression in solid tumors has been strongly associated with poor prognosis and adverse clinical outcome. However, blockade of CXCL12-CXCR4 signaling axis by inhibitors like Nox-A12, FDA approved inhibitor drug AMD3100 have shown limited success cancer treatment. Therefore, exclusive contribution CXCR4-CXCL12 pro-tumorigenic function is questionable. In our pursuit to understand the impact chemokine carcinogenesis, we reveal that instead signaling, presence...
Drug resistance is one of the trademark features Cancer Stem Cells (CSCs). We and others have recently shown that paucity functional death receptors (DR4/5) on cell surface tumour cells major reasons for drug resistance, but their involvement in context CSCs poorly understood. By harnessing CSC specific cytotoxic function salinomycin, we discovered a critical role epigenetic modulator EZH2 regulating expression DRs colon CSCs. Our unbiased proteome profiler array approach followed by ChIP...
To address the need for localized chemotherapy against unresectable solid tumors, an injectable in situ depot-forming lipidic lyotropic liquid crystal system (L3CS) is explored that can provide spatiotemporal control over drug delivery. Although crystals have been studied extensively before but their application as intratumoral depot locoregional has not yet. The developed L3CS present study a low-viscosity fluid having lamellar phase, which transforms into hexagonal mesophase on...
Abstract Owing to its ability induce cellular senescence, inhibit PCNA, and arrest cell division cycle by negatively regulating CDKs as well being a primary target of p53, p21 is traditionally considered tumor suppressor. Nonetheless, several reports in recent years demonstrated pro-oncogenic activities such apoptosis inhibition cytosolic p21, stimulation motility, promoting assembly cyclin D-CDK4/6 complex. These opposing effects on proliferation, supported the observations inconsistent...
Triple-negative breast cancer (TNBC) has profound unmet medical need globally for its devastating clinical outcome associated with rapid metastasis and lack of targeted therapies. Recently, lipid metabolic reprogramming especially fatty acid oxidation (FAO) emerged as a major driver metastasis. Analyzing the expression FAO regulatory genes in cancer, we found selective overexpression acyl-CoA synthetase 4 (ACSL4) TNBC, which is primarily attributed to absence progesterone receptor. Loss...
A general and catalyst-free access to the fused polycyclic N-heterocycles <italic>via</italic> an intramolecular azide–alkene cascade reaction under mild conditions has been developed.
Abstract Drug resistance is one of the trademark features Cancer Stem Cells (CSCs). We and others have recently shown that paucity functional death receptors (DR4/5) on cell surface tumor cells major reasons for drug resistance, but their involvement in context CSCs poorly understood. By harnessing CSC specific cytotoxic function salinomycin, we discovered a critical role epigenetic modulator EZH2 regulating expression DRs colon CSCs. Our unbiased proteome profiler array approach followed by...
Abstract India is the TNBC capital of world due to its highest (31%) prevalence and globally it has huge unmet medical need for high mortality rate. Aggressive early metastasis key such poor clinical outcome. So, there a dire tackle this deadly disease worldwide by targeting metastatic process. Epigenetic modulator Enhancer Zeste homolog 2 (EZH2) promotes hetero-chromatinization target genes tri-methylating lysine at 27 histone H3 (H3K27me3) been shown be associated with prognosis TNBC....
Abstract Ferroptosis, a genetically and biochemically distinct form of programmed cell death, is characterized by iron-dependent accumulation lipid peroxides. Ferroptosis induced in cancer cells inhibition peroxide quencher GPx4. System xc - imports cystine into cytosol for the biosynthesis glutathione. Tumor that are resistant to chemotherapeutic drugs called ‘drug tolerant’ or ‘Persister’ which have vulnerability towards iron mediated death ferroptosis. Unfolded Protein Response (UPR)...
Abstract Triple Negative Breast Cancer (TNBC) is known to have poor prognosis and adverse clinical outcome among all breast cancer subtypes due the absence of available targeted therapy for it. Emerging literature indicates that epigenetic reprogramming now appreciated as a driving force TNBC pathophysiology. High expression modulator EZH2 (Enhancer zeste homolog 2) has been shown correlate with but contribution catalytic (H3K27me3) versus non-catalytic (NC-EZH2) function in growth...
Abstract Ferroptosis, a genetically and biochemically distinct form of programmed cell death, is characterised by an iron-dependent accumulation lipid peroxides. Therapy-resistant tumor cells display vulnerability toward ferroptosis. Endoplasmic Reticulum (ER) stress Unfolded Protein Response (UPR) play critical role in cancer to become therapy resistant. Tweaking the balance UPR make susceptible ferroptotic death could be attractive therapeutic strategy. To decipher emerging contribution...
Abstract Triple-Negative Breast Cancer (TNBC) has profound unmet medical need globally for its devastating clinical outcome associated with rapid metastasis and lack of targeted therapies. Recently, lipid metabolic reprogramming emerged as a major driver breast cancer metastasis. Here, we unveil strong association between the heightened expression fatty acid enzyme, acyl-CoA synthetase 4 (ACSL4) TNBC, which is primarily attributed by selective absence progesterone receptor (PR). Loss ACSL4...
Abstract Chemotherapy resistance is one of the pivotal reasons for cancer-associated huge mortality and morbidity. Cancer cells become therapy resistant by smartly evading execution apoptosis. Death Receptors (DR) are critical pro-apoptotic factors that regulate cell death, paucity death receptors in cancer promotes resistance. High expression CXCR4 strongly correlated with poor prognosis adverse clinical outcomes. Inhibitors CXCL12-CXCR4 axis, such as FDA approved drug plerixafor (AMD3100),...