A5083443087- Phytochemicals and Medicinal Plants
- Natural Antidiabetic Agents Studies
- Ethnobotanical and Medicinal Plants Studies
- Pharmacology and Nanomedicine Research
- Medicinal Plants and Neuroprotection
- Pharmacological Effects of Medicinal Plants
- Synthesis and biological activity
- Essential Oils and Antimicrobial Activity
- Heavy Metals in Plants
- Bioactive natural compounds
- Diverse Scientific Research Studies
- Pharmacological Effects of Natural Compounds
- Natural product bioactivities and synthesis
- Phytochemicals and Antioxidant Activities
- Computational Drug Discovery Methods
- Food Science and Nutritional Studies
- Plant-based Medicinal Research
- Synthesis of Organic Compounds
- Phytochemistry and Biological Activities
- Phytochemical Studies and Bioactivities
- Pelvic floor disorders treatments
- Medicinal Plant Research
- Berberine and alkaloids research
- Bioactive Compounds and Antitumor Agents
- Drug-Induced Hepatotoxicity and Protection
Central Council for Research in Ayurvedic Science
2015-2025
Narendra Dev University of Agriculture and Technology
2024
Memorial Sloan Kettering Cancer Center
2023-2024
Thomas Jefferson University
2019-2024
Ministry of AYUSH
2021-2024
Central Institute of Medicinal and Aromatic Plants
2014-2022
Government of India
2021
Indo Soviet Friendship College of Pharmacy
2018
University of Lucknow
2016
Ayurvedic Institute
2010
Abstract Background Data on the neuromodulatory effects of brain‐derived neurotrophic factor (BDNF) in gastrointestinal tract were recently reported, but there are still no data presence, distribution, and release BDNF tract, including internal anal sphincter (IAS). Methods We examined presence distribution its receptor TrkB different IAS structures (neuronal non‐neuronal) via immunohistochemical immunocytochemical analyses. also monitored an muscle bath (consisting smooth cells [SMCs],...
Recent studies shown that the data of clinical, experimental and epidemiological indicates dietary phytoestrogens, flavonoids polyphenolic compounds have most potent activities for prevention in CVDs. The major class found phytoestrogen. These phytoestrogens are sub-classified into coumestans, prenylflavonoids isoflavones. having active estrogenic effects, polyphenols (also known as polyhydroxyphenols includes tannic acid, ellagitannin. also indicate supplements food nutrients profound...
Plant-based products are a one-of-a-kind source of favoured molecules with wide scaffold variety and broad multi-target potential for the treatment complicated disorders. Among NPs, alkaloids have showed anti-inflammatory, anticancer, cardioprotective, neuroprotective effects, supporting their promise in chronic multifactorial Several recent investigations revealed that isoquinoline (IAs) multimodal potential, sparking growing interest polypharmacological research these small molecules,...
In recent years, there has been a significant increase in interest plant-derived compounds and their function sustaining health avoiding illness. These substances are referred to as phytochemicals or nutraceuticals, which essentially defined food component of that delivers medicinal advantages. Natural bioactive phytochemicals, particularly those found fruits vegetables, components because they may provide advantages associated the prevention variety diseases, including obesity. Health...
Diabetic retinopathy is a microvascular disease that causes blindness. Using acid sphingomyelinase knockout mice, we reported ceramide generation critical for diabetic development. Here, in patients with proliferative retinopathy, identify vitreous imbalance pathologic long-chain C16-ceramides increasing and protective very C26-ceramides decreasing. generate pro-inflammatory/pro-apoptotic ceramide-rich platforms on endothelial surfaces. To geo-localize platforms, invented three-dimensional...
Presently, there are no studies examining the neuromodulatory effects of brain-derived neurotropic factor (BDNF) on basal internal anal sphincter (IAS) tone and nonadrenergic noncholinergic (NANC) relaxation. To examine this, we determined neuromuscular BDNF IAS smooth muscle cells (SMCs) NANC nerve stimulation before after high-affinity receptor tyrosine kinase B (TrkB) antagonist K252a. We also investigated mechanisms underlying BDNF-augmented increase in found that BDNF-increased SMC...
Aging can lead to rectoanal incontinence due internal anal sphincter (IAS) dysfunction, which is characterized by a decrease in IAS tone and contractility an increase nonadrenergic noncholinergic (NANC) relaxation. We aimed determine whether brain-derived neurotropic factor (BDNF) rescues this aging-associated dysfunction (AAID). To do so, we studied the effects of BDNF on basal G protein-coupled receptors (GPCR)-stimulated smooth muscle NANC relaxation Fischer 344 rats representing...
2-Benzylidene tetralone derivatives are exhibited as potent anti-breast cancer agents through microtubule stabilization and induction of apoptosis reactive oxygen species.
Abstract Agro-waste is the outcome of under-utilization bioresources and a lack knowledge to re-use this waste in proper ways or circular economy approach. In Indian medicinal system, root Cyperus scariosus (CS) used at large scale due their vital properties. Unfortunately, aerial part CS treated as agro-waste an under-utilized bioresource. Due knowledge, weed. This present study first ever attempt explore leaves medicinally nutrient rich source. To determine food nutritional values...
Abstract The acute pathogenesis with rapid inflammation enhances the intertrabecular spaces which refers to an increase in intraocular pressure (IOP) uveitic glaucoma. Boerhaavia diffusa ( B. ) plant root contains boeravinone A–J, a class of rotenoids exhibiting hepatoprotective, immunomodulatory, and anti‐inflammatory actions. This article reports comparative silico Rho‐kinase inhibition FP‐agonists study these rotenoids. ADMET reflects suitability terms drug‐likeness, human intestinal...
Glabridin is a major flavonoid in Glycyrrhiza glabra (licorice) root, traditional Asian medicine. reported to have anti-atherogenic, anti-inflammatory and anti-nephritic properties; however its effects on vascular tone remain unexplored.We examined the effect of glabridin rat main mesenteric artery using isometric myography also ELISA measure cGMP levels.Glabridin (30μM) relaxed arteries pre-constricted with thromboxane A2 analog U46619 (0.2μM) by ~60% an endothelium-independent manner....
In the current study, experimental (UV–visible, Fourier transform infrared [FTIR], 1H-NMR and scanning electron microscope) computational FTIR, 1H-NMR, HOMO–LUMO, steric geometric parameters) analyses of acephate, glyphosate, monocrotophos phorate were performed for first time. Computational studies at HF/6–311G(d,p) level theory. It was found that values UV–visible, data in very good agreement with ones. The study may assist future studies, like spectral analysis, pesticide(s) detection,...