A5024103115- Synthesis and biological activity
- Metal complexes synthesis and properties
- Synthesis and Biological Evaluation
- Microtubule and mitosis dynamics
- Bioactive Compounds and Antitumor Agents
- Polyoxometalates: Synthesis and Applications
- Catalytic C–H Functionalization Methods
- Synthesis of Organic Compounds
- Biodiesel Production and Applications
- Ferrocene Chemistry and Applications
- Macrophage Migration Inhibitory Factor
- Pharmacological Effects of Medicinal Plants
- Multicomponent Synthesis of Heterocycles
- Synthesis and Reactions of Organic Compounds
- Phytochemical and Pharmacological Studies
- Saffron Plant Research Studies
- Flavonoids in Medical Research
- Computational Drug Discovery Methods
- Inflammatory mediators and NSAID effects
- Malaria Research and Control
- Cancer Treatment and Pharmacology
- Click Chemistry and Applications
- Immune Response and Inflammation
- Biochemical effects in animals
- Synthesis and Characterization of Heterocyclic Compounds
Central Institute of Medicinal and Aromatic Plants
2014-2024
Chhatrapati Shahu Ji Maharaj University
2024
University of Lucknow
2016
2-Benzylidene tetralone derivatives are exhibited as potent anti-breast cancer agents through microtubule stabilization and induction of apoptosis reactive oxygen species.
Using di-2-furanylethanedione and 5-bromo-3-methylbenzene-1,2-diamine we prepared a monomeric [MoO2(SL)] with Schiff base, as well 4 different compounds using the formulation [MoO2(MSL). We investigate how reacts 1,3-diketones. Several characterizations are discussed in this article, including molar conductance measurement, elemental analysis, UV-Vis, IR, NMR, thermal measurements. Molybdenum has six-coordination number. All five MoO2(VI) have distorted octahedral arrangements. octahedra...
Background: In recent decades, Candida albicans has become a serious issue for public health. The worldwide rapid rise in drug resistance to conventional therapies is the main contributing reason. Moreover, because of their potent activity at low concentrations and apparent lack toxicity, compounds originating from plants are used therapeutic treatments toxicity. Particularly immunocompromised people, species can result wide range ailments. Objectives: Present manuscript describes antifungal...
Present study aimed at a single component cyclization of 2-benzylidene-1-tetralones for the preparation 5H-benzo[c]fluorenes and their antiproliferative activity. This ring closure reaction underwent via reductive in presence aluminium chloride-sodium borohydride system. Ten diverse 5H-benzo[c]fluorene derivatives were prepared evaluated activity against three human cancer cell lines by SRB assay. Four these benzofluorenes exhibited significant effect with IC50 >10.75µM. The best...
In this study, 1-(3-(3, 4-dimethoxyphenyl)-7-methoxy-3, 3 a, 4, 5-tetrahydro-2H-benzo [g] indazol-2-yl) ethan-1-one was synthesized and characterized using spectroscopic techniques (NMR, FT-IR, UV-Vis spectroscopy) single-crystal X-ray diffraction. This compound evaluated in the human cervical cancer cell line. The result showed significant anticancer activity as a control. Quantum chemical calculations have been performed DFT approach to determine structure stability electronic feature...
Aspartic protease enzymes have been critical in the survival of Plasmodium falciparum. Catabolic degradation hemoglobin plays a quintessential involvement parasite life cycles and digestive food vacuole plasmepsin I (PfPlm I) was accessed as possible drug target part antimalarial discovery. Computational methods were utilized to navigate through pool HEA Piperazine analogs figure out best hit screened compounds. For further exploration, MD simulations used on PfPlmI-hit complexes demonstrate...