A5061050479- RNA and protein synthesis mechanisms
- Trypanosoma species research and implications
- Bacterial Genetics and Biotechnology
- Essential Oils and Antimicrobial Activity
- Research on Leishmaniasis Studies
- Computational Drug Discovery Methods
- Fungal Biology and Applications
- Seed and Plant Biochemistry
- Ethnobotanical and Medicinal Plants Studies
- Antibiotic Resistance in Bacteria
- Microbial Natural Products and Biosynthesis
- Phytochemistry and Bioactivity Studies
- Natural product bioactivities and synthesis
- Flavonoids in Medical Research
- RNA Research and Splicing
- HER2/EGFR in Cancer Research
- Synthesis and Characterization of Heterocyclic Compounds
- Nuclear Receptors and Signaling
- Medicinal Plants and Neuroprotection
- Cholinesterase and Neurodegenerative Diseases
- Natural Antidiabetic Agents Studies
- Macrophage Migration Inhibitory Factor
- Phytochemical compounds biological activities
- Monoclonal and Polyclonal Antibodies Research
- Botany, Ecology, and Taxonomy Studies
Central Council for Research in Ayurvedic Science
2022-2025
Indian Institute of Science Education and Research Mohali
2024-2025
Ministry of AYUSH
2022-2024
Jawaharlal Nehru University
2018-2023
Abstract Agro-waste is the outcome of under-utilization bioresources and a lack knowledge to re-use this waste in proper ways or circular economy approach. In Indian medicinal system, root Cyperus scariosus (CS) used at large scale due their vital properties. Unfortunately, aerial part CS treated as agro-waste an under-utilized bioresource. Due knowledge, weed. This present study first ever attempt explore leaves medicinally nutrient rich source. To determine food nutritional values...
Abstract The essential homotetrameric endoribonuclease RNase E of Escherichia coli participates in global RNA turnover as well stable maturation. protomer’s N-terminal half (residues 1–529) bears the catalytic, allosteric, and tetramerization domains, including active site residues D303 D346. C-terminal (CTH, 530–1061) is dispensable for viability. We have previously described a phenomenon recessive resurrection that requires CTH, wherein wild-type homotetramer apparently displays nearly...
Abstract: The definition and comprehension of prebiotics have undergone a substantial transformation over the years, culminating in consensus 2016 among an expert panel from International Scientist Association for Probiotics Prebiotics (ISAPP). This revision suggests that are substances promote growth probiotics, thereby benefitting health host. These no longer restricted to dietary carbohydrates expanded include bioactive compounds such as polyphenols. objective this review is offer...
AbstractBreast cancer is one of the most prevalent and malignant cancers in women. Most breast patients show overexpression HER2 protein. The current study focused on identifying potent inhibitors using a structure-based drug design approach. Prefiltered compounds from Drugbank ZINC database were docked protein FlexX docking tool LeadIT. identified 12 best molecules that interacted strongly with active site also fulfilled ADMET parameters. complexes these further subjected to molecular...
Visceral leishmaniasis is an important public health threat in parts of India. It caused by a protozoan parasite, Leishmania donovani Currently available drugs manifest severe side effects. Hence, there need to identify new drug targets and drugs. Aminoacyl-tRNA synthetases, required for protein synthesis, are known bacterial fungal pathogens. The aim the present study was obtain essentiality data leucyl-tRNA synthetase (LdLRS) gene replacement. Gene replacement studies indicate that this...
Methicillin-resistant Staphylococcus aureus (MRSA) is also known as a superbug because of its resistance against multiple antibiotics. It an opportunistic pathogen that targets immune-compromised people with higher fatality rate and difficult to treat. This study DHFR protein (saDHFR), which crucial enzyme for survival involved in the synthesis 5,6,7,8-tetrahydrofolate, essential cofactor metabolic pathways. In this study, library compounds antimicrobial activity produced by Streptomyces sp....
Mimosa pudica L. (MP) is well-known plant in traditional medicinal system, especially India. Unfortunately, leaves of MP are less explored. To determine the food and nutritional value neglected part (MP), that leaves, phytochemicals metal ions were quantified by newly developed HPLC ICPOES-based methods. The content observed using analysis for chlorogenic acid, catechin, epicatechin was 141.823 (±8.171), 666.621 (±11.432), 293.175 (±12.743) μg/g, respectively. Using GC/MS/MS analysis, fatty...
Alzheimer's disease (AD) is one of the most prevalent neurological ailments, affecting around 50 million individuals globally. The condition characterized by nerve cell damage due to formation amyloid-beta plaques and neurofibrillary tangles. Only a few US Food Drug Administration (FDA)-approved medications are available in market which devoid side effects, thus, making it imperative investigate new alternatives for countering this disease. According recent study, microtubule affinity...
Shyonaka (Oroxylum indicum Vent) is widely used in Ayurveda and ethnomedical practice for the treatment of inflammation, pain, diarrhea, non-healing ulcers, cancer. Owing to high prevalence Epstein-Barr virus (EBV) infection Nasopharyngeal carcinoma (NPC) patients, simultaneous targeting proteins involved both EBV replication NPC proliferation might help manage disease effectively.
There has been an increase in the emergence and spread of drug-resistant pathogens, leading to a steep incline cases antimicrobial resistance. Due this, there is imperative need for development identification new antimicrobials combat this menace But not being completely fulfilled by conventional drug discovery focused on one molecule-one target approach. Polypharmacology, i.e., designing way that acts multiple cellular or molecular targets, approach compounds, gaining attention. DNA gyrase...
Abstract The essential homo-tetrameric endoribonuclease RNase E of Escherichia coli participates in global RNA turnover as well stable maturation. protomer’s N-terminal half (residues 1-529) bears the catalytic, allosteric and tetramerization domains, including critical active site residues D303 D346. C-terminal (CTH, 530-1061) is dispensable for viability. We have previously described a phenomenon recessive resurrection that requires CTH, wherein wild-type homo-tetramer apparently displays...
Abstract BACKGROUND: Serratia marcescens is a well-known Gram-negative, rod-shaped bacterium commonly found in soil, animal skin, hospital environment, and plant-based raw materials. It an opportunistic pathogen that causes serious infections, including pneumonia, bloodstream infection, wound meningitis, respiratory urinary tract infections. Due to multiple resistant strains of S. being identified, new effective antimicrobial compounds/drugs against must be searched. The present study...
BACKGROUND: Shelf-life is an important aspect of raw as well finished drugs. Recently, shelf-life parameters have been included in the Ayurvedic Pharmacopeia India (API). The aim this study to evaluate comparative long-term Raw Vetas ( Salix alba stem bark) and Ghana (a semisolid form Stem bark aqueous extract). METHODS: A stability chamber with environmental conditions 30°C ± 2°C/60% RH 5% was used for Ghana. Physicochemical like loss on drying, pH, total ash, acid insoluble water...