A5060347864- Ovarian function and disorders
- Reproductive Biology and Fertility
- Assisted Reproductive Technology and Twin Pregnancy
- Ovarian cancer diagnosis and treatment
- Sperm and Testicular Function
- Sexual Differentiation and Disorders
- Endometriosis Research and Treatment
- Pregnancy and preeclampsia studies
- Maternal and fetal healthcare
- Reproductive Health and Technologies
- Blood Coagulation and Thrombosis Mechanisms
- Ectopic Pregnancy Diagnosis and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Pregnancy and Medication Impact
- Lipid metabolism and disorders
- Hormonal and reproductive studies
- Cardiovascular Issues in Pregnancy
- Gynecological conditions and treatments
- Pluripotent Stem Cells Research
- Adipose Tissue and Metabolism
- Reproductive Physiology in Livestock
- Renal and related cancers
- Hernia repair and management
- Pituitary Gland Disorders and Treatments
- Minimally Invasive Surgical Techniques
Sapporo Science Center
2014-2023
Ladies College
2012-2013
Sapporo Medical University
2005-2012
The aim of this study is to understand the relationship between polycystic ovary syndrome (PCOS), altered hormonal characteristics and insulin resistance in female-to-male (FTM) transsexual patients.We studied 69 Japanese FTM cases, aged 17-47 years, who were seen Gender Identity Disorder Clinic Sapporo Medical University Hospital December 2003 May 2006. subjects had never received treatment or sex re-assignment surgery. Prior treatment, they physical examinations entailing measurement...
We investigated the mechanism by which a GnRH agonist (GnRHa) affects ovarian vascularity, vascular permeability, and expression of tight junction protein claudin-5 in rat model hyperstimulation syndrome (OHSS). Hyperstimulated rats received excessive doses pregnant mare serum gonadotropin (PMSG; 50 IU/d) for 4 consecutive days, from d 25 to 28 life, followed IU human chorionic (hCG) on 29. Control 10 PMSG 27 hCG GnRHa (leuprolide 100 μg/kg·d) was administered some hyperstimulated either 29...
Hyperandrogenism is the primary manifestation of polycystic ovary syndrome (PCOS), which appears to be caused by excess exposure androgen. As such, androgenized animal models have been developed and investigated study etiology PCOS. Anti-Mullerian hormone (AMH) known associated with follicle growth, its levels are two three times higher in women PCOS than those normal ovaries. We studied how duration androgen administration affects folliculogenesis AMH expression.We divided 30 immature...
Hyperandrogenism is one of the cardinal symptoms in polycystic ovary syndrome and plays a key role pathogenesis syndrome. However, precise effects mechanisms excess androgen during follicular development are still unclear. Here we investigated on mouse follicle vitro. Androgen did not affect growth follicles smaller than 160–180 μm presence follicle-stimulating hormone (FSH). low FSH, supported larger μm, size at which growing acquire FSH-dependency. change mRNA expression various...
Abstract Background The changes occurring in the rodent uterus after parturition can be used as a model of extensive tissue remodeling. As returns to its prepregnancy state, involuting undergoes rapid reduction size primarily due degradation extracellular matrix, particularly collagen. Membrane type-I matrix metalloproteinase (MT1-MMP) is one major proteinases that degrades collagen and most abundant MMP form uterus. Matrix metalloproteinase-2(MMP-2) degrade type I collagen, although main...
There have been no studies analyzing the effect of large aggregates tubular smooth endoplasmic reticulum (aSERT) after conventional in vitro fertilization (cIVF). The aim this study was to investigate whether aSERT can be identified cIVF and association between embryological outcomes oocytes cycles with aSERT. This is a retrospective examining data from showing presence 5–6 h cIVF. To evaluate embryo quality, at least one aSERT-metaphase II (MII) oocyte observed (cycles aSERT) were compared...
Polycystic ovary syndrome (PCOS) is a heterogeneous group of disorders that occur fairly commonly in women reproductive age and are characterized by variety clinical manifestations, including insulin resistance independent obesity. Recent studies suggest altered adipocytokine gene expression closely associated with single nucleotide polymorphisms (SNPs) modulate the and/or function these genes, thereby affecting sensitivity. With mind, we investigated whether SNPs at position -420 resistin...
Abstract Background Zucker fatty (fa/fa) rats are a well-understood model of obesity and hyperinsulinemia. It is now thought that obesity/hyperinsulinemia an important cause endocrinological abnormality, but to date there have been no reports on the changes in ovarian morphology or androgen profile rat models insulin resistance. Methods In this study we investigated effects hyperinsulinemia hormone insulin-resistant (5, 8, 12 16 weeks age, n = 6-7). Results Ovaries from 5-week-old had...
The purpose of this study was to clarify the risk factors and outcomes placental polyp. This retrospective conducted on 1645 patients delivered or aborted in Sapporo Medical University from 2007 through 2011. Transvaginal color Doppler ultrasonography, hysteroscopy, contrast-enhanced MRI 3D-CT angiography were performed. There 1532 deliveries 113 abortions. Seventy-one (4.3%) ART-conceived remaining 1574 (95.7%) non-ART pregnancies. Fifteen (0.91%) cases confirmed as having Nine polyp...
Follicle-stimulating hormone (FSH)-secreting pituitary adenoma is usually a nonfunctioning tumor, but in rare cases it may develop into ovarian hyperstimulation. Several reports have revealed that serum FSH levels are normal to slightly high patients with combined FSH-secreting This finding different from iatrogenic hyperstimulation syndrome (OHSS), which associated extremely of FSH.To describe the clinical course two who developed OHSS adenoma.Endocrine studies were or increased,...
Hyperandrogenism and insulin resistance may be related to the etiology of PCOS. Zucker fa/fa rats with polycystic ovary are obese, have without diabetes mellitus or hyperandrogenism can utilized as PCOS model effects hyperandrogenemia. patients reported elevated levels serum anti-Mullerian hormone (AMH), which has an inhibitory action on folliculogenesis, low adiponectin, blocks apoptosis induces biological in some tissues. Pioglitazone, sensitizer, is administered induce ovulation but...