A5044828173- Reconstructive Surgery and Microvascular Techniques
- Cancer Immunotherapy and Biomarkers
- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Facial Trauma and Fracture Management
- Reconstructive Facial Surgery Techniques
- Periodontal Regeneration and Treatments
- Immune Cell Function and Interaction
- Cleft Lip and Palate Research
- Antenna Design and Analysis
- Cardiovascular Syncope and Autonomic Disorders
- Smoking Behavior and Cessation
- Ear and Head Tumors
- Voice and Speech Disorders
- Infectious Diseases and Mycology
- Cancer Diagnosis and Treatment
- Immune cells in cancer
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Health and Wellbeing Research
- Immunotherapy and Immune Responses
- Head and Neck Anomalies
- Lung Cancer Treatments and Mutations
- Polyomavirus and related diseases
- Metabolism, Diabetes, and Cancer
Memorial Sloan Kettering Cancer Center
2022
Saint Joseph University
2016-2021
Hôtel-Dieu de France
2016-2021
Jefferson University Hospitals
2020
Thomas Jefferson University Hospital
2020
Thomas Jefferson University
2019-2020
Reconstruction of the midface has many inherent challenges, including orbital support, skull base reconstruction, optimizing projection, separation nasal cavity and dental rehabilitation. Subscapular system free flaps (SF) have sufficient bone stock to support complex reconstruction option separate soft tissue components. This study analyzes effect virtual surgical planning (VSP) in SF for on subsite segment contact anatomic position.Retrospective cohort patients with defects that underwent...
Objectives Alterations of cellular metabolism have been implicated in immune dysfunction the tumor microenvironment (TME) head and neck squamous cell carcinoma (HNSCC). Metformin has recently emerged as a candidate interest for combination with immunotherapy HNSCC. This study investigated effect metformin on infiltrates Methods Retrospective analysis T primary specimens from patients enrolled clinical window opportunity trial presurgical metformin. was titrated to standard diabetic dose...
Background When treated nonsurgically with definitive chemoradiation, smokers human papillomavirus (HPV)–positive oropharyngeal squamous cell carcinoma (OPSCC) have a worse prognosis compared their nonsmoking counterparts. To the authors' knowledge, prognostic significance of smoking in surgically patients is unknown. Methods The current study retrospective case series HPV‐positive OPSCC who underwent upfront transoral robotic surgery at single institution from 2010 through 2017. Exclusion...
Squamous cell carcinomas of the head and neck (HNSCC) arise from mucosal keratinocytes upper aero-digestive tract. Despite a common origin similar driver-gene mutations which divert fate differentiation to proliferation, HNSCC are considered heterogeneous group tumors categorized by site within mucosa, presence or absence HPV infection. Tobacco use is major driver carcinogenesis in poor prognosticator that has previously been associated with immune infiltration higher mutation numbers. Here,...
Benign lymphoepithelial cysts (LECs) are rare lesions that can be found in the lateral neck or parotid glands. A 52-year-old woman presented to our clinic with a slowly growing mass of left malar region. MRI was obtained showing cystic lesion lying between mandibular ramus medially, masseter muscle laterally and gland posteriorly. The surgically removed. Complete resection done preservation facial nerve. Histopathology study confirmed diagnosis cyst. No recurrence at 6 months follow up. To...
Importance: Autologous platelet-rich plasma (PRP) has received widespread attention due to its physiologic healing properties, augmenting the body's natural process through platelet activation and release of growth factors. The effects PRP on radiated tissue have been inadequately studied in vivo. Objective: To determine whether can be used improve viability subjected a clinically meaningful stressor, this case rotational skin flap. Design, Setting, Participants: This is prospective trial...
Background: Reconstructing the bony midface and orbit is challenging due to complex anatomy proximity vital structures. Use of an osteocutaneous free flap can restore osseous continuity, support prevent diplopia, allow for dental rehabilitation, improve cosmesis. Osteocutaneous free-flap success has historically been evaluated based on patient symptoms, return normal diet, radiographic union, and/or avoidance complications. However, these methods do not account postoperative position...
Abstract Sinonasal mucosal melanoma is a rare and aggressive cancer with poor prognosis. Surgical resection clear margins, when possible, remains the treatment of choice. Radiation therapy generally used in adjuvant setting improved rates local control following complete resection. Traditional chemotherapeutic agents do not improve locoregional or survival. Immunotherapy has been some responders but overall relatively outcomes. These outcomes highlight need for new more prospective trials...