A5071935405- Lipid Membrane Structure and Behavior
- Spectroscopy and Quantum Chemical Studies
- MRI in cancer diagnosis
- Lanthanide and Transition Metal Complexes
- Electron Spin Resonance Studies
- Molecular spectroscopy and chirality
- Electrostatics and Colloid Interactions
- Cancer, Hypoxia, and Metabolism
- Magnetism in coordination complexes
- Protein Interaction Studies and Fluorescence Analysis
- Polymer Surface Interaction Studies
- Ultrasound and Hyperthermia Applications
- Nuclear Physics and Applications
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Advanced Battery Materials and Technologies
- Photoacoustic and Ultrasonic Imaging
- Luminescence and Fluorescent Materials
- Antimicrobial agents and applications
- Supercapacitor Materials and Fabrication
- Advancements in Battery Materials
- Pickering emulsions and particle stabilization
- Renal cell carcinoma treatment
- Nanopore and Nanochannel Transport Studies
- Protein Structure and Dynamics
The University of Texas MD Anderson Cancer Center
2021-2025
The University of Texas Health Science Center at Houston
2023
Northwestern University
2018
Nanjing University of Posts and Telecommunications
2018
We report vibrational sum frequency generation (SFG) spectra in which the C-H stretches of lipid alkyl tails fully hydrogenated single- and dual-component supported bilayers are detected along with O-H stretching continuum above bilayer. As salt concentration is increased from ∼10 μM to 0.1 M, SFG intensities region decrease by a factor 2, consistent significant absorptive-dispersive mixing between χ(2) χ(3) contributions signal process charged interfaces. A method for estimating surface...
Charge densities of cationic polymers adsorbed to lipid bilayers are estimated from second harmonic generation (SHG) spectroscopy and quartz crystal microbalance with dissipation monitoring (QCM-D) measurements. The systems surveyed included poly(vinylamine hydrochloride) (PVAm), poly(diallyldimethylammonium chloride) (PDADMAC), poly-l-lysine (PLL), poly-l-arginine (PLR), as well polyalcohol controls. Upon accounting for the number positive charges associated each polyelectrolyte, binding...
Tumor acidosis is an important biomarker for aggressive tumors, and extracellular pH (pHe) of the tumor microenvironment can be used to predict evaluate responses chemotherapy immunotherapy. AcidoCEST MRI measures pHe by exploiting pH-dependent chemical exchange saturation transfer (CEST) effect iopamidol, exogenous CT agent repurposed CEST MRI. However, all fitting methodologies acidoCEST data have limitations. Herein we present results application machine learning extracting values from...
The extracellular tumor microenvironment of many solid tumors has high acidosis and protease activity. Simultaneously assessing both characteristics may improve diagnostic evaluations aggressive the effects anticancer treatments. Noninvasive imaging methods have previously been developed that measure pH or can detect enzyme activity using chemical exchange saturation transfer (CEST) magnetic resonance (MRI). Herein, we a single-hybrid CEST agent simultaneously evaluate combination dual-power...
We report vibrational sum frequency generation (SFG) spectra in which the C–H stretches of lipid alkyl tails fully hydrogenated single- and dual-component supported bilayers are detected along with O–H stretching continuum above bilayer. As salt concentration is increased from ~10 μM to 0.1 M, SFG intensities region decrease by a factor 2, consistent significant absorptive-dispersive mixing between χ(2) χ(3) contributions signal process charged interfaces. A method for estimating surface...
AcidoCEST MRI can measure the extracellular pH of tumor microenvironment. We have further refined our “Bloch fitting” method, and shown that this analysis method accurately precisely without additional information, with an accuracy 0.03 units. In addition, we developed a machine learning classify as > 7.0 or < 6.5 units (PPV=0.94, NPV=096), regression estimate mean absolute error 0.031
<div> <p>We report vibrational sum frequency generation (SFG) spectra in which the C–H stretches of lipid alkyl tails fully hydrogenated single- and dual-component supported bilayers are detected along with O–H stretching continuum above bilayer. As salt concentration is increased from ~10 μM to 0.1 M, SFG intensities region decrease by a factor 2, consistent significant absorptive-dispersive mixing between χ(2) χ(3) contributions signal process charged interfaces. A method for...
We report vibrational sum frequency generation (SFG) spectra in which the C–H stretches of lipid alkyl tails fully hydrogenated single- and dual-component supported bilayers are detected along with O–H stretching continuum above bilayer. As salt concentration is increased from ~10 μM to 0.1 M, SFG intensities region decrease by a factor 2, consistent significant absorptive-dispersive mixing between χ(2) χ(3) contributions signal process charged interfaces. A method for estimating surface...
<a></a><a>While mixing nanoparticles with certain biological molecules can result in coronas that afford some control over how engineered nanomaterials interact living systems, corona formation mechanisms remain enigmatic. Here, we report spontaneous lipid formation, i.e. without active mixing, upon attachment to stationary bilayer model membranes and bacterial cell envelopes, present ribosome-specific outcomes for multi-cellular organisms. Experiments show...
We report vibrational sum frequency generation spectra from supported lipid bilayers in which the OH and CH stretching signals are probed at different salt concentrations. Atomistic simulations show a negligible impact of on spectra, indicating observed SFG intensity changes due to chi(3) potential dependent contributions. These further analyzed contact exact-zero reference states. Further experiments identify specific hydrogen bonding interactions between interfacial water molecules PC head...
<h3>Background</h3> While immune checkpoint blockade (ICB) treatments such as programmed death-1 (αPD-1) and cytotoxic T lymphocyte antigen-4 (αCTLA-4) shifted the paradigm of cancer treatment, this ICB combination produces objective response rates only 35.9% for patients with non-small cell lung cancer,<sup>1</sup> 58% melanoma patients.<sup>2</sup> Tumors are able to suppress anti-tumor cells that drive through reduction extracellular tumor pH,<sup>3–5</sup> by promoting hypoxia in...