A5007827622- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Regulation of Appetite and Obesity
- Cancer, Stress, Anesthesia, and Immune Response
- Neuroscience and Neuropharmacology Research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Neuroscience of respiration and sleep
- Hypothalamic control of reproductive hormones
- Stress Responses and Cortisol
- Pharmacological Receptor Mechanisms and Effects
- Pain Mechanisms and Treatments
- Biochemical effects in animals
- Schizophrenia research and treatment
- Neuroendocrine Tumor Research Advances
- Tryptophan and brain disorders
- Chemical Synthesis and Analysis
- Neuroendocrine regulation and behavior
- Treatment of Major Depression
- Peptidase Inhibition and Analysis
- Migraine and Headache Studies
- Multiple Sclerosis Research Studies
- Biochemical Analysis and Sensing Techniques
- Neuroblastoma Research and Treatments
- Sleep and Wakefulness Research
- Chemokine receptors and signaling
Universidad de Salamanca
2016-2025
Instituto de Estudios de Ciencias de la Salud de Castilla y León
2016-2025
John Wiley & Sons (United Kingdom)
2019
Hudson Institute
2019
Instituto de Neurociencias de Castilla y León
2000-2014
Instituto de Biomedicina de Sevilla
2014
Hospital Universitario Virgen del Rocío
2006-2014
Weatherford College
2014
Universidad de Málaga
1997-2006
Consejo Superior de Investigaciones Científicas
2000-2005
The substance P (SP)/neurokinin (NK)-1 receptor system plays an important role in the development of cancer. No in-depth studies involvement this breast cancer (BC) have been carried out, and action exerted by drug aprepitant on BC cells is currently unknown. We show human cell lines: i) these express mRNA for NK-1 receptor; ii) they overexpress receptors; iii) involved their viability; iv) SP induces proliferation; v) antagonists block SP-induced mitogen stimulation cells; vi) specific...
Osteosarcoma is a highly malignant bone tumor in children and adolescents. Aprepitant selective high‑affinity antagonist of the human neurokinin‑1 (NK‑1) receptor (NK1R) with robust antitumor activity. No data exist on presence NK1R osteosarcoma whether this responds to antagonists. Here, we analyzed expression cell line MG-63 western blot analysis PCR found significant both at protein mRNA levels. We further studied growth inhibitory capacity aprepitant other antagonists vitro using an MTS...
Background. Glioblastoma or glioma is the most common malignant brain tumor. Patients have a prognosis of approximately 15 months, despite current aggressive treatment. Neurokinin-1 receptor (NK-1R) occurs naturally in human glioma, and it necessary for tumor development. Objective. The purpose study was to increase knowledge about involvement substance P (SP)/NK-1R system glioma. Methods. Cellular localization NK-1R SP studied GAMG U-87 MG cell lines by immunofluorescence. contribution both...