Abstract Traumatic brain injury ( TBI ) contributes to fatalities and neurological disabilities worldwide. While primary causes immediate damage, secondary events contribute long‐term defects. Contusions (Ct) are injuries correlated with poor clinical prognosis, can expand leading delayed deterioration. Pericontusion PC (penumbra), the region surrounding Ct, also edema, increased intracranial pressure, ischemia, outcome. Analysis of Ct therefore assist in understanding pathobiology its...

Introduction: The cerebellum harbors a variety of different functions, ranging from motor to cognitive and linguistic skills. This complex functional landscape is founded on an intricate specific architecture intracerebellar white matter fibers surrounding the dentate nucleus, which extremely difficult visualize with modern imaging techniques. Though, surgeons may greatly benefit detailed knowledge this anatomy. Historic studies have proved how anatomic dissections allow accurate study...

OBJECTIVE Patients with advanced moyamoya disease have chronic cerebrovascular insufficiency superimposed acute ischemic insults, leading to brain atrophy and cognitive decline. The outcomes of revascularization procedures in patients marked are not yet clearly known. METHODS This retrospective study used an approach based on the global cerebral scale identify severe from a single-surgeon series undergoing January 2015 2024. Clinical (modified Rankin Scale [mRS] score, improvement symptoms...

<title>Abstract</title> <bold>Background: </bold>Microvascular anastomosis in rats serves as an essential training model for surgeons to master microvascular anastomosis, often involving significant bleeding after clamp release due the high blood pressure (120–140 mmHg) femoral arteries relative vessel size. Traditionally it is addressed by use of hemostatic measures such local tissue wrap or synthetic agents. This study explores autologous platelet-rich plasma (PRP) gel a agent during...

Mitochondrial function and the ensuing ATP synthesis are central to functioning of brain contribute neuronal physiology. Most studies on neurodegenerative diseases have highlighted that mitochondrial dysfunction is an important event contributing pathology. However, human mitochondria in various disorders heavily rely post mortem samples. As tissues influenced by pre- factors, we investigated effect these variables function.We examined whether (represented enzymes antioxidant activities)...

The nature and extent of recovery after traumatic brain injury (TBI) is heterogeneous. Apolipoprotein E (APOE) plays a major role in repair cell membrane growth neurites following to cells. Studies done on the western population have shown that APOE e4 genotype associated with poor survival neurotrauma.To explore association polymorphism outcome TBI patient from tertiary care hospital exclusive for neurological diseases south India.Ninety eight patients who sustained mild moderate (computed...

Background: Cervical spine movement during intubation with direct laryngoscopy can predispose to new-onset neurological deficits in patients cervical instability. While fiberoptic-guided (FGI) is mostly preferred such patients, this not always possible. Videolaryngoscopy results less than and may be an alternative FGI The objective of study was compare awake those McGrath videolaryngoscope-guided (VGI) undergoing surgery for Methods: Forty-six adult upper instability scheduled stabilization...

OBJECT Hydrocephalus is one of the commonest complications tubercular meningitis (TBM), and its incidence increasing with HIV epidemic. Literature evaluating role ventriculoperitoneal shunts in HIV-positive patients TBM their long-term prognosis scarce. METHODS Between June 2002 October 2012, 30 hydrocephalus underwent shunt placement. Thirty age-, sex-, grade-matched HIV-negative were randomly selected as control group. Outcome was analyzed at discharge (short-term outcome) follow-up...

ABSTRACT Background: The aim of the study is to correlate surgical outcome with radiological changes in patients Chiari I malformation (CMI) syrinx. We also compared long-term functional and radiographic CM1 treated posterior fossa decompression (PFD) or without duroplasty. Patients Methods: From December 2013 October 2015, 22 who underwent surgery diagnosis CMI syrinx were included study. Measurements performed on preoperative postoperative magnetic resonance (MR) scans using same software....

Syringomyelia secondary to cervical spondylosis is a rare entity encounter in clinical practice. We discuss the case of 53-year-old lady who presented with syringomyelic syndrome and was found have on imaging. Cine-MRI revealed an obstruction cerebrospinal fluid (CSF) flow spinal subarachnoid space. Decompression same led radiological improvement. There potential causal association between syringomyelia. MRI CSF studies may help deciding course treatment such cases. A subset patients...

Objective The aim of this study is to share our experience in per-operative embolization aggressive vertebral haemangioma and compare the surgical outcome with existing modalities management. Background Vertebral accounts for 12% benign lesions column detected incidentally. Rarely they may enlarge, cause pain neurological deficit because spinal cord compression, body or arch expansion, pathological fracture. Treatment options symptomatic include pre-operative transarterial embolization,...

patients with ischemic cerebrovascular disease, particularly Moyamoya, complex aneurysms unamenable to direct clip reconstruction and tumors that may requiring vessel sacrifice achieve complete resection (9,18,19).Neurosurgical literature is lacking, in establishing a proper curriculum for training learn perfect this difficult art.Its importance though, has been emphasized from time time; Professor M.Gazi Yaşargil, himself being great proponent (21).█ INTRODuCTION M icro-vascular anastomosis...

Biochemical analyses of many brain diseases have highlighted that oxidative damage proteins and astrogliosis are important events associated with pathology. However, human studies on the status protein oxidation/nitration [indicated by expression glial fibrillary acidic (GFAP)] heavily depend postmortem tissues might be altered pre factors. To evaluate effect these variables, we tested whether GFAP expression, oxidized proteins, nitrated (by 3-nitrotyrosine or 3-NT) were affected in brains...

Abstract Spinal cord development occurs through three consecutive periods of gastrulation, primary nerulation and secondary neurulation. Aberration in these stages causes abnormalities the spine spinal cord, collectively referred as dysraphism. They can be broadly classified anomalies gastrulation (disorders notochord formation integration); neurulation (premature dysjunction nondysjunction); combined Correlation with clinical embryological data common imaging findings provides an organized...

Osteoblastomas and aneurysmal bone cysts are uncommon benign tumors of the spine. Their presentation can vary between diffuse pain, restriction neck movements, torticollis, radiculopathy, myelopathy. Complete excision is best treatment to achieve a cure, but recurrence not uncommon. A combination two conditions in pediatric population extremely rare. To authors’ knowledge, only 2 cases such cervical spine have been reported literature. We report case 2-year-old child having right C4 lateral...

The human brain displays oxidant and antioxidant markers with regional specificity that directly impinges on neuronal function in aging disease states. Similarly, the activities might exhibit differential intracellular distribution rendering subcellular structures differentially vulnerable to toxic insults. To investigate of postmortem brain, we assayed superoxide dismutase (SOD), glutathione (GSH), peroxidase (GPx), reductase (GR), glutathione-S-transferase (GST) cytosol synaptosomal...