A5040628759- Drug-Induced Hepatotoxicity and Protection
- Circadian rhythm and melatonin
- Ovarian function and disorders
- Chemotherapy-induced organ toxicity mitigation
- Biochemical effects in animals
- Liver Disease and Transplantation
- Antibiotics Pharmacokinetics and Efficacy
- Pharmacological Effects and Toxicity Studies
- Nitric Oxide and Endothelin Effects
- Genomics, phytochemicals, and oxidative stress
- Eicosanoids and Hypertension Pharmacology
- Stress Responses and Cortisol
- Phytochemicals and Antioxidant Activities
- Pharmacological Effects of Natural Compounds
- Hypothalamic control of reproductive hormones
- Cardiac Ischemia and Reperfusion
- Organ Transplantation Techniques and Outcomes
- Liver physiology and pathology
- Advanced Glycation End Products research
- Dietary Effects on Health
- Phytochemicals and Medicinal Plants
- Acute Lymphoblastic Leukemia research
- Flavonoids in Medical Research
- Testicular diseases and treatments
- Effects of Radiation Exposure
Inonu University
2015-2024
Walter de Gruyter (Germany)
2021
KUKA (Germany)
2021
Lokman Hekim Üniversitesi
2019
Iğdır Üniversitesi
2019
Bülent Ecevit University
2009
We investigated the protective effect of NADPH oxidase inhibitor apocynin on testicular damage induced by ischemia-reperfusion injury in rats.A total 32 rats were randomly divided into 4 groups. Controls underwent left scrotal exploration only. The 3 groups with 4-hour torsion followed 1-hour detorsion. only group and plus saline torsion, received 10 ml/kg intraperitoneally at minute 210 ischemia then 20 mg/kg determined histopathological findings performed specific biochemical analyses.In...
This experimental study was designed to explore the protective effect of apocynin, NADPH-oxidase inhibitor, on kidney damage induced by ischemia/reperfusion (I/R) in a rat model.Thirty-two rats were randomly divided into control group and three I/R groups (1-hour ischemia followed 23-hour reperfusion). Three treated apocynin (20 mg/kg, i.p.) at two different time points (before during ischemia). The histopathological findings, including apoptotic changes, also tissue malondialdehyde (MDA),...
The aim of this study was to examine the effects melatonin on ionized radiation-induced salivary gland damage using an experimental model.Thirty-two rats were randomized into four groups: (i) control group (C, n = 8) that received intraperitoneal (i.p.) 0.9% NaCl; (ii) (M, i.p. 5 mg/kg melatonin; (iii) radiotherapy (RT, underwent irradiation; (iv) plus (M+RT, melatonin, followed by irradiation 30 min later; and (v) (RT+M, later. medications administered for days glands excised 10...
Preventive and/or therapeutic interventions for ischemic heart disease have gained considerable attention worldwide. We investigated the mechanism(s) underlying cardioprotection of apocynin (APO) and whether it attenuates isoproterenol (ISO)-induced myocardial damage in vivo. Thirty-two male Wistar Albino rats were randomised into four groups (n = 8 each group): Group I (Control); II (ISO), ISO was given intraperitoneally (ip) (150 mg/kg/d) daily 2 consecutive days; III (APO + ISO), APO...
Radiation colitis typically emerges during radiotherapy of intra-abdominal malignancies. While the underlying mechanism remains unclear, it is considered that free oxygen radicals act like cellular mediators to cause colonic damage. Apocynin (APO) prevents oxidative stress and apoptotic cell death by inhibiting NADPH oxidase, preventing formation radicals. The aim present study was investigate protective effect APO, a strong antioxidant antiinflammatory agent, on radiation induced damage in...
Background and aim It has been reported that intestinal ischemia–reperfusion (I/R) injury results from oxidative stress caused by increased reactive oxygen species. Dexpanthenol (Dxp) is an alcohol analogue with epitelization, anti-inflammatory, antioxidant, increasing peristalsis activities. In the present study, was to investigate protective therapeutic effects of Dxp against I/R injury. Materials methods Overall, 40 rats were assigned into five groups including one control, alone Dxp,...
Cecal ligation and puncture (CLP) is a commonly used model of sepsis in vivo. We investigated the effects dexpanthenol (DXP) on heart, lung aorta CLP-induced rats. Rats were divided into four groups eight: group 1, sham (SH); 2 (DXP), 500 mg/kg DXP injected intraperitoneally (i.p.); 3 (CLP), CLP performed; 4 (CLP + DXP), i.p. after CLP. Heart, specimens harvested for histopathological biochemical analysis. Heart rate increased compared to 1; administration did not alleviate this change. In...
Methotrexate is a familiar chemotherapeutic preferred in wide range of clinical fields such as leukemia, psoriasis, rheumatoid arthritis, neoplastic and autoimmune disorders. However, methotrexate therapy has limitations it causes severe side effects from which liver damage the most important one. Several antioxidant compounds have been studied against related toxicity, but dexpanthenol not experienced. Vitamin B5-derived usual therapeutic having potent anti-inflammatory effect. In this...
Abstract Background Despite the available treatments, pulmonary arterial hypertension (PAH) prognosis is poor. Objectives We aimed to investigate effects of alamandine (ALA), melatonin (MEL), and ALA + MEL in PAH. Methods The rats were randomly divided into Control ( n = 10), monocrotaline (MCT) 12), 12) groups. PAH was induced by MCT. ALA, MEL, groups received 50 μg/kg/day 10 mg/kg/day respectively, for 35 days. Echocardiographic hemodynamic measurements tissue analyses (morphometric,...
The MrgD receptor agonist, alamandine (ALA) and Mas AVE0991 have recently been identified as protective components of the renin-angiotensin system. We evaluated effects ALA on cardiovascular function remodeling in angiotensin (Ang) II-induced hypertension rats. Sprague Dawley rats were subject to 4-week subcutaneous infusions Ang II (80 ng/kg/min) or saline after which they treated with (50 μg/kg), (576 ALA+AVE0991 during last 2 weeks. Systolic blood pressure (SBP) heart rate (HR) values...
To determine the role of Molsidomine in preventing radiation-induced retinopathy after head and neck region irradiation rats with a single radiation dose 15 Gy.Male Wistar albino were randomly grouped into five as follows: (1) control group rats, which applied through an intraperitoneal (i.p.) vehicle without radiotherapy (RT); (2) RT received Gy daily 0.1 ml i.p. for 5 consecutive days; (3) molsidomine (MOL) treated days by 4 mg/kg/day MOL; (4) plus MOL (RT+MOL) 10 (5) MOL+RT before RT. At...
The aim of this study was to evaluate the acute effect high-dose acetylsalicylic acid (ASA) on kidney and testis, potential protective therapeutic effects melatonin ASA-related pathology. A total 40 rats were randomly divided into following 5 groups ( n = 8): group 1: control, not given any drug; 2: only 200 mg/kg ASA given; 3: 45 min before administering ASA; 4: after 5: given. histopathological changes biochemical findings; such as malondialdehyde (MDA), superoxide dismutase (SOD),...
A significant clinical condition known as testicular torsion leads to permanent ischemic damage the tissue and consequent loss of function in testicles.In this study, it was aimed evaluate protective effects Astaxanthin (ASTX) on rats with torsion/detorsion light biochemical histopathological data.Spraque Dawley 21 were randomly divided into three groups; sham, (TTD) astaxanthin + (ASTX TTD).TTD ASTX TTD groups underwent for 2 hours then detorsion 4 hours.Rats group given 1 mg/kg/day by oral...
Objective: Amikacin (AK) is a wide-spectrum antibiotic routinely used to treat gram-negative and some gram-positive bacterial infections. However, its use limited due potential cause nephrotoxicity an increase in reactive oxygen radicals. The main goal of this study was investigate the effect carvacrol (CAR) on AK-induced rats. Methods: Thirty-two Sprague Dawley rats were randomly separated into four groups: control (0.9% NaCl solution sunflower oil), AK (400 mg/kg), CAR+AK (80 mg/kg CAR+400...
We investigated possible healing effects of melatonin (MEL) on biochemical and histological changes in the lungs rat offspring caused by exposure to nicotine (NT) utero. Pregnant rats were divided randomly into five groups. The SP group was treated with physiological saline. EA ethyl alcohol. MEL MEL. NT NT. + At end study, biochemistry histopathology lung tissue examined. Reduced alveolar development increased numbers macrophages mast cells observed compared SP, also found malondialdehyde...
Diabetes mellitus is one of the chronic metabolic diseases which characterized by microvascular and macrovascular complications. This study was designed to investigate improving effects amnioguanidine on aortic damage in a streptozotocin (STZ) induced diabetic rat model.Thirty-two male Sprague-Dawley rats divided into four groups as follows: Control, Aminoguanidine, Diabetes, Diabetes+Aminoguanidine. Experimental diabetes single dose STZ (45 mg/kg) intraperitoneally. After administration...