While the pathogenesis of acetic acid (AA)-induced colitis is unclear, reactive oxygen species are considered to have a significant effect. The aim present study was elucidate therapeutic potential dexpanthenol (Dxp) on amelioration in rats. Group I (n=8; control group) intrarectally administered 1 ml saline solution (0.9%); group II [n=8; AA] 4% AA into colon via rectum as single dose for three consecutive days; III + Dxp) at same dosage from day 4, and Dxp intraperitoneally; IV similarly...

Dexmedetomidine (dex) is a potent, highly selective and specific α2-adrenoreceptor agonist. This experimental study was designed to investigate protective therapeutic effect of two different doses dex, on kidney damage induced by ischemia-reperfusion (I/R) in rats. Male Sprague−Dawley rats were divided into four groups, each including 10 animals: control group, group; treated groups with μg/kg dex 100 dex. After removing right the rats, left has performed ischemia during 40 min reperfusion...

This experimental study was designed to explore the protective effect of apocynin, NADPH-oxidase inhibitor, on kidney damage induced by ischemia/reperfusion (I/R) in a rat model.Thirty-two rats were randomly divided into control group and three I/R groups (1-hour ischemia followed 23-hour reperfusion). Three treated apocynin (20 mg/kg, i.p.) at two different time points (before during ischemia). The histopathological findings, including apoptotic changes, also tissue malondialdehyde (MDA),...

This experimental study was designed to investigate protective and therapeutic effects of Dexpanthenol (Dxp), an alcoholic analogue pantothenic acid, on kidney damage induced by ischemia-reperfusion (I/R) in rats.Forty rats were randomly divided into a control group 4 I/R groups (1 h ischemia followed 23 reperfusion). Three treated Dxp (500 mg/kg, i.p.) at 3 different time points (before ischemia, during late The histopathological findings including apoptotic changes, also tissue...

The aim of this study was to examine the effects melatonin on ionized radiation-induced salivary gland damage using an experimental model.Thirty-two rats were randomized into four groups: (i) control group (C, n = 8) that received intraperitoneal (i.p.) 0.9% NaCl; (ii) (M, i.p. 5 mg/kg melatonin; (iii) radiotherapy (RT, underwent irradiation; (iv) plus (M+RT, melatonin, followed by irradiation 30 min later; and (v) (RT+M, later. medications administered for days glands excised 10...

Preventive and/or therapeutic interventions for ischemic heart disease have gained considerable attention worldwide. We investigated the mechanism(s) underlying cardioprotection of apocynin (APO) and whether it attenuates isoproterenol (ISO)-induced myocardial damage in vivo. Thirty-two male Wistar Albino rats were randomised into four groups (n = 8 each group): Group I (Control); II (ISO), ISO was given intraperitoneally (ip) (150 mg/kg/d) daily 2 consecutive days; III (APO + ISO), APO...

This study was designed to investigate the protective effects of sitagliptin on renal damage induced by ischemia reperfusion (I/R) in rats. For this, rats were randomly divided into four groups (n = 8): (1) sham group, which only underwent right nephrectomy; (2) nephrectomy and left kidney (1 h) (24 group (I/R); (3) 5 mg/kg administrated per-oral once a day for two weeks; (4) weeks before I/R 8). Sitagliptin-treated that demonstrated significant decrease serum urea nitrogen creatinine also,...

Radiation colitis typically emerges during radiotherapy of intra-abdominal malignancies. While the underlying mechanism remains unclear, it is considered that free oxygen radicals act like cellular mediators to cause colonic damage. Apocynin (APO) prevents oxidative stress and apoptotic cell death by inhibiting NADPH oxidase, preventing formation radicals. The aim present study was investigate protective effect APO, a strong antioxidant antiinflammatory agent, on radiation induced damage in...

This experimental study was designed to investigate both protective and therapeutic effects of aminoguanidine (AG), on radiotherapy (RT)-induced oxidative stress in kidney testis. Forty rats were divided into five groups equally as follows: (i) control, (ii) RT, (iii) AG, (iv) AG+RT (v) RT+AG group. Histopathological findings biochemical evaluations, including tissue malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), (GSH), total oxidant status...

Background and aim It has been reported that intestinal ischemia–reperfusion (I/R) injury results from oxidative stress caused by increased reactive oxygen species. Dexpanthenol (Dxp) is an alcohol analogue with epitelization, anti-inflammatory, antioxidant, increasing peristalsis activities. In the present study, was to investigate protective therapeutic effects of Dxp against I/R injury. Materials methods Overall, 40 rats were assigned into five groups including one control, alone Dxp,...

Dexpanthenol (Dxp) plays a major role in cellular defense and repair systems against oxidative stress inflammatory response it has not yet been evaluated treatment of bronchopulmonary dysplasia (BPD). We tested the hypothesis that proposes whether Dxp decreases severity lung injury an animal model BPD.Forty rat pups were divided into four groups: control, control + Dxp, hyperoxia Dxp. All animals processed for histology tissue analysis. The degree inflammation, antioxidant capacity was...

Cisplatin is an antineoplastic agent used in adults and children for the treatment of various malignant diseases. It can cause irreversible ototoxicity. Genistein a phytoestrogen. functions as antioxidant cell cycle inhibitor by inhibiting DNA topoisomerase tyrosine protein kinase enzymes. The protective effect genistein preventing cisplatin-induced ototoxicity levels oxidative stress was investigated.32 Sprague Dawley rats were 4 groups (control, cisplatin, cisplatin + genistein,...

To explore the protective and curative effects of molsidomine (MOL) on doxorubicin (DOX)-induced cardiac damage in vivo rat heart.Forty rats were randomized into five groups (n = 8): (1) control group; (2) MOL group (10 mg/kg for 21 days); (3) DOX (a single dose 20 mg/kg); (4) + (3 days after DOX, 10 continued days), (5) (24 h a 21-day regimen MOL, DOX). The monitored mean arterial blood pressure, heart rate, O2 saturation, electrocardiography. Heart tissue levels malondialdehyde (MDA),...