Abstract: In this study, we investigated the effect of melatonin on cisplatin‐induced spermiotoxicity using quantitative, biochemical and histopathological approaches. Cisplatin (CP, 7 mg/kg) (10 were intraperitoneally injected. The rats decapitated 5th (short‐term group) or 50th day (long‐term after CP injection. Traits reproductive organs, sperm characteristics, testicular histological findings, lipid peroxidation in tissue determined. Melatonin mitigated CP‐induced reductions testes,...

Free radicals, calcium overloading and loss of membrane phospholipids play an important role in the development ischemia/reperfusion (I/R) injury. Melatonin is a well-known antioxidant free radical scavenger. may also reduce intracellular inhibit lipid peroxidation. This study was designed to investigate effects melatonin on I/R-induced cardiac infarct size vivo rat model. We investigated glutathione (GSH) levels, levels which are influenced by oxidative stress, malondialdehyde (MDA) index...

Abstract: Myocardial ischemia–reperfusion (I/R) represents a clinically relevant problem associated with thrombolysis, angioplasty and coronary bypass surgery. I/R injury is believed to be consequence of free radical generation in the heart especially during period reperfusion. The pineal secretory product, melatonin, known potent scavenger pharmacological concentrations have been shown reduce I/R‐induced cardiac damage isolated rat hearts. However, physiological role melatonin prevention...

Cisplatin [cis-diaminedichloroplatinum(II), CDDP] is a widely used antineoplastic drug. However, it has major side-effects such as acute tubular necrosis (ATN). There are number of studies concerning the role reactive oxygen radical species in pathophysiology CDDP-dependent ATN. Several antioxidant agents have been reported to prevent this side-effect but there no study regarding protective action either physiological or pharmacological concentrations melatonin. Melatonin, chief secretory...

Objective To investigate the effect of melatonin on antioxidant enzyme activity and renal tubular necrosis induced by gentamicin. Materials methods Twenty‐four adult male Sprague‐Dawley rats were divided into three equal groups. In group 1, injected with vehicle (controls), in 2 they gentamicin for 5 days 3 plus days. At 24 h after last injection, killed cortex separated from medulla. Most was homogenized but a small sample fixed formaldehyde solution histological examination light...

It is well established that some agents such as aminoglycosides generate free oxygen radicals, leading to an increased oxireductase production, which in turn increases tissue toxicity. The aim of this study test whether melatonin, the chief secretory product pineal gland and a highly effective antioxidant radical scavenger, reduces nephrotoxicity caused by amikacin (AK). Herein, we investigated physiologic pharmacological role melatonin influencing AK-induced nephrotoxicity. For this,...

Cardiac arrhythmias during ischemia–reperfusion (I/R) are believed to be related free radicals generated in the heart especially period of reperfusion. The pineal secretory product, melatonin, is known a potent radical scavenger and its pharmacological concentrations have been shown reduce I/R‐induced isolated rat hearts. However, physiological role melatonin prevention these unknown. Rats were pinealectomized (Px) or sham‐operated (non‐Px) (control) 2 months before I/R studies. To produce...

Testicular torsion is a common syndrome that could lead to infertility. We investigated the therapeutic effects of lycopene, an antioxidant caretenoid, on testicular ischemia/reperfusion (IR) injury resembles torsion. Male Wistar albino rats were divided into three groups: sham (n = 6), IR 18), and with lycopene (IRL, n 18). Left artery vein was occluded for 1 h, followed by reperfusion 3 24 h or 30 days in IRL animals. Either corn oil (vehicle) (4 mg/kg) administrated once daily gavage...

The objective of this study was to evaluate the antioxidant effects propolis, caffeic acid phenethyl ester (CAPE; active compound in propolis), and pollen on biochemical oxidative stress biomarkers rat kidney tissue inhibited by Nω -nitro-L-arginine methyl (L-NAME). evaluated were paraoxonase (PON1), index (OSI), total status (TAS), oxidant (TOS), asymmetric dimethylarginine (ADMA), nuclear factor kappa B (NF-κB). TAS levels PON1 activity significantly decreased samples L-NAME-treated group...

Abstract It has been found that remote organ/limb temporary ischemia, known as ischemic conditioning, can provide protection against the formation of lethal outcome. Current evidence suggests aging and age‐releated comorbidities impair cardioprotective effects conditionings. In conjuction with aging, decrease in melatonin synthesis from pineal gland have role pathogenesis age‐related cardiovascular diseases. this study, we investigated perconditioning (RIPerC) physiological pharmacological...

Reduction in the synthesis or bioavailability of nitric oxide plays a significant role development hypertension. Propolis is resinous product collected by honeybees from various plant sources. Tyrosine hydroxylase (TH) rate-limiting enzyme biosynthesis catecholamines. The aim this study was to examine effect propolis on blood pressure (BP), TH, and total RNA levels adrenal medulla, heart, hypothalamus tissues chronic synthase (NOS)-inhibited rats Nw-nitro-l-arginine methyl ester (L-NAME)....

Doxorubicin (Dox) is a widely used antineoplastic drug. Oxygen radical-induced injury of membrane lipids considered to be the most important factor responsible for development Dox-induced cardiotoxicity. The pineal secretory product, melatonin, known potent free radical scavenger and its pharmacological concentrations have been shown reduce cardiac damage. However, physiological role melatonin in prevention this damage unknown. We investigated effects on changes levels malondialdehyde (MDA),...

Background High blood pressure effects heart and vessels. Development of pathogenesis is the result oxidative stress. We aimed to investigate antioxidant propolis, caffeic acid phenethyl ester (CAPE), pollen on hearts rats which chronic nitric oxide synthase (NOS) inhibited through Nω-nitro-L-arginine methyl (L-NAME). Paraoxonase 1 (PON1), total status (TAS), oxidant (TOS), stress index (OSI), asymmetric dimethylarginine (ADMA), nuclear factor-κB (NF-κB) were analyzed heart.Material Methods...

Increased levels of reactive oxygen species, alterations in nitric oxide synthesis, and increased migration neutrophils to the ischemic tissue play an important role pathophysiology myocardial ischemia-reperfusion (IR) injury. In this study, we have evaluated effects melatonin on myeloperoxidase (MPO) activity, glutathione (GSH), lipid peroxidation levels, blood pressure L-NAME-induced hypertensive rats with or without IR. NOS inhibitor L-NAME was administrated before inducing cardiac...

Purpose: In this study, the effects of apocynin, an NADPH oxidase inhibitor, on levels inducible nitric oxide synthase (iNOS) and toll-like receptor 4 (TLR4), which are inflammatory mediators in myocardial ischemia-reperfusion (MIR) injury, myeloperoxidase (MPO), is indicator neutrophil infiltration endogenous inhibitor asymmetric dimethyl arginine (ADMA) increasing with oxidative stress were investigated. Methods: MIR injury was accomplished by application occlusion for 30 minutes...

Aminoguanidine is an inhibitor of nitric oxide synthase (NOS), with high selectivity for the inducible isoform (iNOS). In addition to being NOS, aminoguanidine also exhibits antioxidant activity. Recent studies suggest that reduces ischaemia–reperfusion (I/R)-induced damage. However, role aminoguanidine, in renal injury associated I/R remains unknown. This study was designed investigate effects on injury. There were three groups eight rats each. induced by occlusion left vessels 60 min,...

Reduction in the synthesis or bioavailability of nitric oxide plays a significant role development myocardial infarction and hypertension. Numerous studies suggest that melatonin reduces blood pressure (BP) ischemia/reperfusion (I/R) injury rats. The effects on BP I/R-induced cardiac infarct size L-NAME-induced hypertensive rats remains unknown. This study was designed to investigate chronic synthase inhibited by L-NAME. Rats received L-NAME for 15 days produce hypertension last 5 before I/R...