A5063109071- Nitric Oxide and Endothelin Effects
- Circadian rhythm and melatonin
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Pancreatitis Pathology and Treatment
- Regulation of Appetite and Obesity
- Birth, Development, and Health
- Alcohol Consumption and Health Effects
- Eicosanoids and Hypertension Pharmacology
- Drug-Induced Hepatotoxicity and Protection
- Essential Oils and Antimicrobial Activity
- Phytochemistry and Biological Activities
- Pesticide Exposure and Toxicity
- Neuropeptides and Animal Physiology
- Neurological Disease Mechanisms and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Chemotherapy-induced cardiotoxicity and mitigation
- Metabolism, Diabetes, and Cancer
- Dietary Effects on Health
- Pregnancy and preeclampsia studies
- Antioxidant Activity and Oxidative Stress
- Reproductive Biology and Fertility
- Helicobacter pylori-related gastroenterology studies
- Liver Disease Diagnosis and Treatment
- Cassava research and cyanide
Muğla University
2013-2024
Adıyaman University
2018
Inonu University
2000-2010
Marymount University
2009
Stomatology Hospital
2003
The present study was planned to investigate the protective effect of 10 % and 20 apricot-containing feed on carbon tetrachloride (CCl 4 )-induced hepatic steatosis damage. Adult male Wistar rats ( n 42) were divided into six groups seven each, as follows: control group; CCl +10 apricot +20 group. All fed with or for 5 months. injections applied at dose 1 mg/kg 3 d end In group, vacuolated hepatocytes necrosis seen, especially in centrilobular area. Hepatocytes showed an oedematous...
Cancer is a major public health problem in many areas of the world. Many anticancer drugs current clinical use have been isolated from plant species or are based on such substances. Thymol (5-methyl-2-isopropylphenol) an oxygenated aromatic compound monoterpene group. It main constituent thyme essential oil and shows antioxidant, antiseptic antiproliferative properties. The aim this study to determine activity apoptotic effect thymol prostate cancer (PC-3, DU145), breast (MDA-MB-231), lung...
Ovarian cancer is the seventh most common worldwide in women. Many anticancer drugs are currently used clinically have been isolated from plant species or based on such substances. Thymol (5-methyl-2-isopropylphenol) and carvacrol oxygenated aromatic compounds monoterpene group. They main constituents of thyme essential oil show antiproliferative, antioxidant, antiseptic properties. The aim this study to compare antiproliferative apoptotic effects thymol SKOV-3 ovarian cell line. cells were...
This study was planned to investigate the protective effect of l(+)-ascorbic acid (Vit C) on CCl(4)-induced hepatotoxicity and oxidative stress in liver Wistar rats (Rattus Norvegicus, strain Wistar). Twenty-four adult male were fed with standard rat chow diet for 10 days randomly divided into four groups six each as follows: (1) control, (2) CCl(4), (3) "CCl(4) + Vit C", (4) C groups. CCl(4) applied belonging C" subcutaneously at 1 mg kg(-1) dose 3 days. "Vit group intraperitoneally 300 All...
Breast cancer is the most common in women ın world. Many anticancer drugs are currently used clinically have been isolated from plant species or based on such substances. Linalool aromatic compounds monoterpene group. It main constituents of essential oils and show antiproliferative, antioxidant, antiseptic properties. The aim this study was to investigate antiproliferativeand apoptotic, effects linalool MCF-7 MDA-MB-231 human breast cells. cells were treated with different concentrations...
Doxorubicin (Dox) is a widely used antineoplastic drug. Oxygen radical-induced injury of membrane lipids considered to be the most important factor responsible for development Dox-induced cardiotoxicity. The pineal secretory product, melatonin, known potent free radical scavenger and its pharmacological concentrations have been shown reduce cardiac damage. However, physiological role melatonin in prevention this damage unknown. We investigated effects on changes levels malondialdehyde (MDA),...
This study was planned to observe the effects of nitric oxide synthesis on antioxidative defense enzymes and pancreatic tissue histology in caerulein-induced acute pancreatitis. Acute pancreatitis induced by intraperitoneal injections 50 microg/kg caerulein, L-arginine used for NO induction N(omega)-nitro-L-arginine methyl ester (L-NAME) inhibition. In caerulein group acinar cell degeneration, interstitial inflammation, oedema haemorrhage were detected. Pancreatic damage scores decreased...
Abstract The objective of this study was to investigate the beneficial effects caffeic acid phenethyl ester (CAPE) on gentamicin (GM)‐induced nephrotoxicity in Wistar rats. Twenty‐one adult rats were divided into three groups as follows: control group, GM and + CAPE group. Control group injected with 5% ethanol, treated 100 mg/kg pretreated 10 μ mol/kg for 2 days, then exposed at same dose. Drug injections applied 12 days. Twenty‐four hours after last injection, killed kidneys quicky...
This study is designed to investigate the protective effects of propolis in ocular tissues against chronic alcohol exposure.Wistar albino rats were used this study. Rats divided into 4 groups, and each group was fed a special liquid diet which contained an equal amount calories. The control without propolis. We added (150 mg/kg) second group. third alcohol, concentration increased progressively. fourth including alcohol. To counterbalance caloric intake, we decreased glucose for groups 3 4....
Abstract The aims of this study were to observe the changes in antioxidative defense enzymes and renal morphology after 7,12‐dimethyl‐benz[ a ]anthracene (7,12‐DMBA) administration mice investigate possible protective effects melatonin against 7,12‐DMBA‐induced damage comparison with vitamin E + selenium (vit Se). Forty female divided into four groups: control, DMBA, DMBA vit Se melatonin. In group, given injections 7,12‐DMBA (20 mg/kg). group received mg/kg 90 1.8 μ g/kg). 4.2 experiment...
AbstractObjective: Our objective in this study was to investigate the ultrastructure of endothelial and muscle cells human umbilical vessels both normal pre-eclamptic pregnancies. Methods: Ten cords from (36, 38 40 weeks) four pregnancies (40 were collected immediately after vaginal deliveries. Umbilical veins arteries isolated fixed phosphate-buffered 2.5% glutaraldehyde solution (pH 7.2) for 4 h postfixed with 1% osmium tetroxide at 4°C 2 h. The sections embedded Araldit CY 212. Ultrathin...
Aim: Acetylsalicylic acid (ASA, aspirin), which is one of the most frequently used drugs in world, causes severe gastric mucosal injury. Nitric oxide (NO) synthesized from L-arginine by nitric synthase (NOS). NOS can be inhibited Nω-nitro-L-arginine methyl ester (L-NAME) and stimulated supplementing diet with (L-Arg). The aim this study was to investigate role NO on injury induced ASA. Materials Methods: Male Sprague-Dawley rats were divided into seven groups: control, ASA, ASA+L-NAME,...
Purpose: Doxorubicin (DOX) is a wide-spectrum antibiotic used for chemotherapy. Its side effects limit treatment. Crocin one of the carotenoids that has both anti-inflammatory and antioxidant activities. We aimed to evaluate crocin against doxorubicin-induced testicular damage in rats. Materials Methods: Forty Wistar rats were divided into four groups. Group 1: Control, 2: Crocin, 3: DOX, 4: DOX+Crocin (n=10, all). Testis tissues stained with Hematoxylin-Eosin. The diameters seminiferous...