A5015673854- Neurogenesis and neuroplasticity mechanisms
- RNA Research and Splicing
- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- Signaling Pathways in Disease
- Cellular transport and secretion
- Galectins and Cancer Biology
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Mesenchymal stem cell research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advanced Fluorescence Microscopy Techniques
- School Health and Nursing Education
- Immune cells in cancer
- RNA Interference and Gene Delivery
- Neurobiology and Insect Physiology Research
- Influenza Virus Research Studies
- Periodontal Regeneration and Treatments
- Wound Healing and Treatments
- Tissue Engineering and Regenerative Medicine
- Microfluidic and Bio-sensing Technologies
- Photoreceptor and optogenetics research
- Vaccine Coverage and Hesitancy
- Hydrogels: synthesis, properties, applications
- Nerve injury and regeneration
Stanford University
2018-2024
Draper Laboratory
2023
Harvard University
2016-2020
Abstract Myelin is essential for rapid nerve signaling and increasingly found to play important roles in learning diverse diseases of the CNS. Morphological parameters myelin such as sheath length are thought precisely tune conduction velocity, but mechanisms controlling morphology poorly understood. Local calcium has been observed nascent sheaths can be modulated by neuronal activity. However, role formation remains incompletely Here, we use genetic tools attenuate oligodendrocyte during...
Soft extracellular matrix boosts the activation of MSCs by TNFα to generate and recruit monocytes in a paracrine manner.
Myelin is required for rapid nerve signaling and emerging as a key driver of CNS plasticity disease. How myelin built remodeled remains fundamental question neurobiology. Central to myelination the ability oligodendrocytes add vast amounts new cell membrane, expanding their surface areas by many thousand-fold. However, how membrane build or remodel not fully understood. Here, we show that addition requires exocytosis mediated vesicular SNARE proteins VAMP2/3. Genetic inactivation VAMP2/3 in...
Actin is one of the most abundant proteins in eukaryotic cells and a key component cytoskeleton. A range small molecules has emerged that interfere with actin dynamics by either binding to polymeric F-actin or monomeric G-actin stabilize destabilize filaments prevent their formation growth, respectively. Among these, latrunculins, which bind affect polymerization, are widely used as tools investigate actin-dependent cellular processes. Here, we report photoswitchable version latrunculin,...
Nearly half of American adults suffer from gum disease, including mild inflammation gingival tissue, known as gingivitis. Currently, advances in therapeutic treatments are hampered by a lack mechanistic understanding disease progression physiologically relevant vascularized tissues. To address this, we present high-throughput microfluidic organ-on-chip model human tissue containing keratinocytes, fibroblast and endothelial cells. We show the triculture exhibits physiological structure,...
Objective: To assess the impact of a campus community health worker program (HealthPALs) on student influenza vaccination. Participants: Undergraduate students at northeastern US university (enrollment 6650), seasons 2011–2012 through 2015–2016. Methods: Study design: Difference-in-differences analysis vaccination dormitory clinics during intervention vs. baseline. Intervention: In first year, HealthPALs conducted in-person peer outreach several flu clinics. Subsequent years, an enhanced...
ABSTRACT Actin is one of the most abundant proteins in eukaryotic cells and a key component cytoskeleton. A range small molecules have emerged that interfere with actin dynamics by either binding to polymeric F-actin or monomeric G-actin stabilize destabilize filaments prevent their formation growth, respectively. Amongst these, latrunculins, which bind affect polymerization, are widely used as tools investigate actin-dependent cellular processes. Here, we report photoswitchable version...
2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) is an abundant constituent of central nervous system non-compact myelin, frequently used as a marker antigen for myelinating cells. The catalytic activity CNPase, the 3'-hydrolysis nucleotides, well characterised
Abstract 2′,3′‐Cyclic nucleotide 3′‐phosphodiesterase (CNPase) is an abundant constituent of central nervous system non‐compact myelin, and its loss in mice humans causes neurodegeneration. Additionally, CNPase frequently used as a marker antigen for myelinating cells. The catalytic activity CNPase, the 3′‐hydrolysis 2′,3′‐cyclic nucleotides, well characterised vitro, but vivo function remains unclear. interacts with actin cytoskeleton to counteract developmental closure cytoplasmic channels...
Abstract Myelin is required for rapid nerve signaling and emerging as a key driver of CNS plasticity disease. How myelin built remodeled remains fundamental question neurobiology. Central to myelination the ability oligodendrocytes add vast amounts new cell membrane, expanding their surface areas by many thousand-fold. However, how membrane build or remodel unknown. Here, we show that addition requires exocytosis mediated vesicular SNARE proteins VAMP2/3. Genetic inactivation VAMP2/3 in...