A5000086402- Hormonal Regulation and Hypertension
- Medical Research and Treatments
- Traditional Chinese Medicine Studies
- Acupuncture Treatment Research Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Renal cell carcinoma treatment
- Eicosanoids and Hypertension Pharmacology
- Synthesis and bioactivity of alkaloids
- Neurological Disease Mechanisms and Treatments
- Cancer, Lipids, and Metabolism
- Healthcare and Venom Research
- Peroxisome Proliferator-Activated Receptors
- Phytochemistry and Biological Activities
- Social and Behavioral Studies
- Dermatology and Skin Diseases
- Medicinal Plant Extracts Effects
- Chronic Kidney Disease and Diabetes
- Transplantation: Methods and Outcomes
- Traditional Chinese Medicine Analysis
- Bioactive Compounds and Antitumor Agents
- Adrenal Hormones and Disorders
- Psoriasis: Treatment and Pathogenesis
- Cardiac, Anesthesia and Surgical Outcomes
- Autophagy in Disease and Therapy
- Heme Oxygenase-1 and Carbon Monoxide
Henan University of Traditional Chinese Medicine
2020-2024
Lanzhou University
2016-2021
Lanzhou University Second Hospital
2016-2021
Hebei Medical University
2020
Dalian Medical University
2020
Second People’s Hospital of Yibin
2019
North Sichuan Medical University
2018
Second Hospital of Tianjin Medical University
2015
Tianjin Medical University
2015
General Hospital of Shenyang Military Region
2013
<b><i>Introduction:</i></b> Gout arthritis is an inflammatory disease characterized by severe acute pain. The goal of pharmacological gout treatments to reduce pain, and thereby increase the patient’s quality life. Kv7/M channel activators retigabine flupirtine show analgesic efficacy in animal models osteoarthritic We hypothesized that these drugs may also alleviate <b><i>Objective:</i></b> To determine effects on pain behavior associated with...
Oxidative stress, endoplasmic reticulum (ER) and neuronal cell apoptosis have been considered as the main pathogenesis factors of brain injury after intracerebral hemorrhage (ICH). Chrysophanol (CHR) has proved to neuroprotective effects, but role underlying mechanisms CHR in ICH remain unclear. HT22 cells were dealt with hemin mimic an vitro model then subjected treatment or without CHR. The viability, apoptosis, ER oxidative stress evaluated by conducting counting kit-8 (CCK-8),...
The study is designed to observe the mechanism of Tongfu Xiefei Guanchang Solution(TFXF) in treatment acute lung injury(ALI) rats by improving intestinal barrier and flora structure via p38 mitogen-activated protein kinase(p38 MAPK)/myosin light chain kinase(MLCK) signaling pathway. Sixty SPF-grade Wistar were randomly divided into control(CON) group, lipopolysaccharide(LPS) group(7.5 mg·kg~(-1)), LPS + dexamethasone(DEX) group(3.5 high-dose(HD)-TFXF group(14.74 g·kg~(-1)),...
Background: To explore the mechanisms of raw rhubarb and wine-processed treatment in a rat model intracerebral hemorrhage (ICH). Methods: After adapting to their environment, 30 male Wistar rats were divided into 5 groups: blank control group (CK) (normal saline), sham operation (SICH) ICH (ICH) + enema (RO) (raw 3.60 g/kg), (WRO) (wine-processed g/kg). The (once day) was given since 3 days before treatment, consistently until 12 hours, 24 days, 7 post operation. Serum oxidative stress...
Ricin is a highly toxic type 2 ribosome-inactivating protein (RIP) which extracted from the seeds of castor beans. considered potential bioterror agent and no effective antidote for ricin exists so far. In this study, by structural modification retrograde transport blocker Retro-2cycl, series novel compounds were obtained. The primary screen revealed that compound 27 has an improved anti-ricin activity compare to positive control. vitro pre-exposure evaluation in Madin–Darby Canine Kidney...
Abstract Lumiracoxib is a selective cyclooxygenase‐2 inhibitor, which has been reported to cause rare but severe liver injury. Considering that lumiracoxib carboxylic group in the molecule, glucuronidation form acylglucuronide would be one of possible mechanisms lumiracoxib‐induced The aim this study was identify metabolites were formed via acyl‐glucuronidation human microsomes using glutathione (GSH) and N ‐acetyl‐lysine (NAL) as trapping agents by liquid chromatography combined with high...
Previous studies have reported a neuroprotective effect of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) against traumatic brain injury. In accordance with the Marmarou method, rat models diffuse axonal injury were established. 8-OH-DPAT was intraperitoneally injected into model rats. treated rats maintained at constant temperature served as normal controls. TUNEL results revealed that neural cell swelling, tissue necrosis and apoptosis occurred around injured tissue. Moreover, number...
The objective of this study was to evaluate the degradation characteristics and embolic effect gelatin microspheres (GMSs) produced domestically in China through an experimental comparing embolization rabbit renal arteries using GMSs tris-acryl microspheres.Sixteen healthy adult New Zealand white rabbits were randomly divided into two groups. Group A embolized with a diameter 150-200 μm (n = 8), B 100-200 8). femoral artery puncture catheterization. Renal angiography rechecks hematoxylin...
The expression of TES, a novel tumor suppressor gene, is found to be down-regulated in the left anterior descending aorta patients with coronary artery disease (CAD) compared non-CAD subjects. This study aimed investigate TES during development atherosclerosis rabbits.Thirty-two New Zealand rabbits were randomly divided into normal diet (ND) and high-fat (HFD) groups. Body weight serum lipid levels measured at 0, 4, 12 weeks after treatment. degree thoracic aortas was analyzed by...
Abstract Multiple sclerosis (MS) is a common autoimmune illness that difficult to treat. The upregulation of Th17 cells critical in the pathological process MS. Hederagenol (Hed) has been shown lower IL‐17 levels, although its role MS pathophysiology uncertain. In this study, we explore whether Hed could ameliorate by modulating cell differentiation, with goal identifying new treatment targets for experimental encephalomyelitis (EAE) mouse model was conducted and intraperitoneally injected...
Methysticin is one of the naturally occurring bioactive constituents extracted from Piper methysticum Forst. In present study, we intended to investigate inhibitory effect methysticin on cytochrome P450 (P450) enzymes. exhibited time-, concentration-, and NADPH-dependent inhibition CYP2C9 using diclofenac as a probe substrate. Approximately 85% activity was inhibited by at 50 μM after 30 min preincubation with human liver microsomes in presence NADPH. The kinetic parameters KI, kinact,...
Objectives: To confirm whether the blood pressure variation rate is a risk factor for cognitive decline in elderly patients with hypertension, this meta-analysis provides basis improving function of hypertension patients. Methods: "blood rate", "cognition" and "hypertension" as inscription, retrieval Pubmed, Cochrane Library, Embase Web science to find correlated observational studies track reference related articles. Revman 5.3.0 software had on correlation between hypertension. Results:...
Objective To survey the nutritional status of maintenance hemodialysis (MHD) patients and explore role oral supplement (ONS) in improving among MHD patients. Methods From January 2016 to December 2017, one hundred sixty-two were selected randomly from centre No. 2 peoples’ Hospital assessed malnutrition incidence by objective score nutrition on dialysis (OSND). Patients with divided into control group ONS randomly, conducted traditional education, while as a substitution diet basis...
Objective: To assess the efficacy and safety of a novel hormone therapy, drospirenone combined with 17-β-estradiol (DRSP/E2) in postmenopausal hypertensive women. Design Method: A systemic literature search PubMed, Embase, Cochrane Library, Web Science (up to Oct. 2015) was performed. Studies were screened independently by two researchers according inclusion exclusion criteria which included only randomized controlled trials (RCT) about for women hypertension. The methodological quality...
Objectives: The Renin Angiotensin System (RAS) plays an important role in the pathophysiology of hypertension. LCZ696, a first-in-class drug which comprises ARB valsartan and angiotensin receptor neprilysin (NEP) inhibitor (ARNi). main goal present study was to evaluate protein gene expression RAS components cardiac aorta tissue female spontaneously hypertensive rats. Methods: Sixteen-week-old normotensive Wistar-Kyoto (WKY) rats (SHR) were used this study. Tail-cuff method performed measure...
Objectives: Aim to explores the characteristic of central blood pressure and arterial stiffness in essential hypertension with overweight or obesity Methods: Two hundreds subjects were selected from Lanzhou University Second Hospital during November 2014 2015. All patients divided into three groups by BMI (body mass index), normal group (N = 75, 18.5 ≤ < 24), 71, 24 28), 54, ≥ 28). Body height, weight, waist circumference, fast plasma glucose, lipid, peripheral brachial measured. Central...
Objective To understand the prevalence of esophageal cancer-related knowledge rural residents in high incidence area, and to provide evidence for prevention, early diagnosis treatment cancer. Methods A self-made questionnaire was used evaluate cognitive status influence cancer among from 3 villages towns which are areas Huangdian, Fuyi Lianghe Sichuan province July 4 12. Results A total 1 007 participated survey. There were 937 valid questionnaires with an effective rate 93.0%....