A5019607360- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Pediatric health and respiratory diseases
- Respiratory viral infections research
- Tracheal and airway disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Dysphagia Assessment and Management
- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Peptidase Inhibition and Analysis
- Congenital Diaphragmatic Hernia Studies
- Acute Myocardial Infarction Research
- Dietary Effects on Health
- Circadian rhythm and melatonin
- Asthma and respiratory diseases
- Inflammatory Biomarkers in Disease Prognosis
- Infant Nutrition and Health
- Cancer-related gene regulation
- Immunodeficiency and Autoimmune Disorders
- Exercise and Physiological Responses
- Ear and Head Tumors
Hefei University of Technology
2024-2025
Anhui University
2025
Third People's Hospital of Hefei
2024
Anhui Medical University
2024
Second Affiliated Hospital of Nanchang University
2021-2022
Nanchang University
2021-2022
Jiangxi Provincial Cancer Hospital
2021
State Key Laboratory of Respiratory Disease
2016-2020
Guangzhou Medical University
2015-2020
First Affiliated Hospital of Guangzhou Medical University
2016-2020
Abstract Background Systemic Inflammatory Response Index (SIRI), a composite inflammatory marker encompassing neutrophils, monocytes, and lymphocytes, has been recognized as reliable of systemic inflammation. This article undertakes an analysis clinical data from ST-segment Elevation Myocardial Infarction (STEMI) patients, aiming to comprehensively assess the relationship between SIRI, STEMI, degree coronary stenosis. Methods The study involved 1809 patients diagnosed with STEMI years 2020...
Bronchial dilation testing is an important tool to assess airway reversibility in adults with bronchiectasis. This study aims investigate the association of bronchodilator response (BDR) and clinical parameters bronchiectasis, utility BDR indicate lung function decline risks bronchiectasis exacerbations (BEs).We recruited 129 patients clinically stable Baseline measurements included assessment sputum inflammation matrix metalloproteinase-8 -9, bacterial culture, spirometry, bronchial test...
Mounting evidence supports the notion of "one airway, one disease."To determine whether chronic rhinosinusitis (CRS) poses adverse impacts on Chinese adults with bronchiectasis.We enrolled 148 consecutive clinically stable bronchiectasis. CRS diagnosed based 2012 EP3OS criteria. We systematically evaluated bronchiectasis etiology, radiology, lung function, sputum bacteriology, airway inflammatory biomarkers, Bronchiectasis Severity Index, cough sensitivity and healthcare resource...
Background: Defective airway host-defense (e.g., altered mucus properties, ciliary defects) contributes to the pathogenesis of bronchiectasis. This study aims determine whether genetic mutations associated with defective are implicated in Methods: Based on systematic screening 32 frequently reported bronchiectasis-associated genes, we performed next-generation sequencing (NGS) peripheral blood samples from 192 bronchiectasis patients and 100 healthy subjects. The variant distribution...
<h3>BACKGROUND:</h3> Both impulse oscillometry and spirometry can reflect small-airway disorders. The objective of this work was to investigate the diagnostic value parameters their correlation with radiology, disease severity, sputum bacteriology in mild moderate bronchiectasis (bronchiectasis severity index <9) validate these findings sensitivity analyses (mild bronchiectasis). <h3>METHODS:</h3> We recruited 94 subjects 26 healthy subjects. compared using receiver operating...
To analyze the outcomes and toxicities of induction chemotherapy (ICT) followed by concurrent chemoradiotherapy (CCRT) plus adjuvant (ACT) in patients with locoregionally advanced nasopharyngeal carcinoma (LA-NPC).Retrospective analysis 163 LA-NPC referred from August 2015 to December 2018 was carried out. All underwent platinum-based ICT CCRT ACT.The median follow-up time 40 months, ranging 5 69 months. The 3-year disease-free survival (DFS), overall (OS), locoregional recurrence-free...
Abstract Little is known about the comparative diagnostic value of lung clearance index (LCI) and maximal mid-expiratory flow (MMEF) in bronchiectasis. We compared performance, correlation concordance with clinical variables, changes LCI MMEF% predicted during bronchiectasis exacerbations (BEs). Patients stable underwent history inquiry, chest high-resolution computed tomography (HRCT), multiple-breath nitrogen wash-out test, spirometry sputum culture. who experienced BEs these measurements...
Bronchiectasis is a debilitating disease with chronic airway infection. Proteobacteria, the dominant phylum, can be detected high-throughput sequencing.To stratify Proteobacteria compositions according to culture findings in bronchiectasis.We sampled sputum, split for and 16srRNA sequencing, from 106 patients stable bronchiectasis 17 healthy subjects. Paired sputa 22 were collected during exacerbations convalescence.Forty-five, 41, 20 clinically had isolated Pseudomonas aeruginosa (PA),...
Bronchiectasis is a chronic debilitating suppurative disease that significantly impacts quality of life. Clinical outcomes like exacerbations, are usually physician centered; however, the patients' experience, health-related behaviors, and expectations have frequently been neglected. In addition, health perceptions may be influenced by their culture.To determine perception behavior in adults with bronchiectasis.We performed semi-directive interviews, which were audiotaped, 60 bronchiectasis...
Pseudomonas aeruginosa (PA) colonization confers poor prognosis in bronchiectasis. However, the biomarkers and biological pathways underlying these associations are unclear.To identify roles of PA bronchiectasis by exploring for sputum exosomal microRNA profiles.We enrolled 98 patients with clinically stable 17 healthy subjects. Sputum was split bacterial culture sequencing, followed validation quantitative polymerase chain reaction. Bronchiectasis were stratified into non-PA groups based on...
Background Mosaicism and hyperinflation are common pathophysiologic features of bronchiectasis. The magnitude ventilation heterogeneity might have been affected by the degree hyperinflation. Some studies evaluated discriminative performance lung clearance index (LCI) in bronchiectasis patients, but additive diagnostic value metrics to LCI is unknown. Objective To compare ratio residual volume total capacity (RV/TLC), along with normalized RV/TLC, terms performance, correlation concordance...
Epidermal growth factor receptor (EGFR) is a therapeutic target in nasopharyngeal carcinoma (NPC). The optimal combined modality of anti--EGFR monoclonal antibodies, induction chemotherapy (ICT), concurrent and radiotherapy for NPC remains poorly defined. None previous studies have developed subsequent treatment strategies on the basis stratification according to efficacy following ICT plus anti-EGFR mAbs. This study aims increase intensity patients with poor reduce toxicity favourable by...
During the development of diet-induced obesity, change energy matebolism is closely related to function circadian clock in mammals. Luteolin (LU), one most common natural flavonoids riched many edible plants, can ameliorate obesity by activating adipose tissue browning, but its effect on this process remains poorly understood. Here we found that dietary LU improved misalignment expenditure high-fat diet (HFD)-fed wild-type (WT) mice. Moreover, efficiently elevated UCP1 levels during dark...
Bronchiectasis is a debilitating chronic inflammatory airway disease which arises from multiple etiologies. The interplay among the etiology, altered microenvironment and defective host-defense may have predisposed to recurrent chest infections of pathogens (1,2) that correlate with bronchiectasis exacerbations increased mortality.
<b>Background:</b> Epstein-Barr virus (EBV) is prevalent and has been implicated in chronic obstructive pulmonary disease idiopathic fibrosis. However, the roles of EBV adults with bronchiectasis are unclear. We aimed to delineate association between infection bronchiectasis. <b>Methods:</b> recruited 108 patients 18 healthy controls. collected sputum for detection during follow-up, an interval every 3 6 months, at exacerbation. <b>Results:</b> 442 specimens from patients. The Bronchiectasis...
Background: Epstein-Barr virus (EBV) has been implicated in the pathogenesis and progression of chronic obstructive pulmonary disease.Methods: To determine whether EBV correlates with bronchiectasis severity, exacerbations progression, we collected induced sputum healthy controls, spontaneous at 3-6-month intervals onset patients between March 2017 October 2018. was detected quantitative polymerase chain reaction.We 442 samples from 108 50 controls. When stable, yielded significantly higher...