A5049664187- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Pharmacological Receptor Mechanisms and Effects
- Epilepsy research and treatment
- Neuropeptides and Animal Physiology
- Neurotransmitter Receptor Influence on Behavior
- Inflammatory mediators and NSAID effects
- Tryptophan and brain disorders
- Treatment of Major Depression
- Curcumin's Biomedical Applications
- Eicosanoids and Hypertension Pharmacology
- Pharmacological Effects and Toxicity Studies
- Nitric Oxide and Endothelin Effects
- Medicinal Plants and Neuroprotection
- Adenosine and Purinergic Signaling
- Pesticide Exposure and Toxicity
- Stress Responses and Cortisol
- Ion channel regulation and function
- Biochemical effects in animals
- Berberine and alkaloids research
- Cholinesterase and Neurodegenerative Diseases
- Alkaloids: synthesis and pharmacology
- Phenothiazines and Benzothiazines Synthesis and Activities
- Neurological Disease Mechanisms and Treatments
- Sleep and Wakefulness Research
University of California, Davis
2012-2025
Panjab University
2005-2022
University of California Davis Medical Center
2009-2020
National Forensic Sciences University
2013-2015
Department of Biotechnology
2013
Weatherford College
2009
University of the Punjab
2007
Chandigarh University
2007
Abstract This unit describes a protocol to perform chemical kindling in mice. Kindling is chronic animal model of epilepsy that has been extensively studied understand the process epileptogenesis and discover novel anti‐epileptic compounds. phenomenon where sub‐convulsive stimulus (either or electrical), if applied repetitively intermittently, will ultimately lead generation full‐blown convulsions. can be induced either by (1) electrical stimulation different brain regions (electrical...
Curcumin, the principal curcuminoid found in spice turmeric, has recently been studied for its active role treatment of various central nervous system disorders. Curcumin demonstrates neuroprotective action Alzheimer's disease, tardive dyskinesia, major depression, epilepsy, and other related neurodegenerative neuropsychiatric The mechanism is not completely understood. However, it hypothesized to act majorly through anti-inflammatory antioxidant properties. Also, a potent inhibitor reactive...
Humans and animals acutely intoxicated with the organophosphate soman can develop sustained status epilepticus (SE) that rapidly becomes refractory to benzodiazepines. We compared antiseizure efficacy of midazolam, a current standard care treatment for OP-induced SE, versus combined therapy midazolam allopregnanolone (ALLO) in rat model soman-induced SE. Soman-intoxicated male rats robust seizure behavior high-amplitude electroencephalographic (EEG) activity were administered (0.65 mg, i.m.)...
Studies have suggested that alpha(2)-adrenoceptors strongly affect monoaminergic neurotransmission by enhancing not only noradrenergic but also serotonergic firing rates. With this background in mind, the present study was undertaken to monitor effect of addition yohimbine (alpha(2)-adrenoceptor antagonist) fluoxetine (selective serotonin reuptake inhibitor) or venlafaxine (dual inhibitors both and norepinephrine) Porsolt's forced swim test (FST) using male Laca strain mice.The immobility...
Tetramethylenedisulfotetramine (tetramine; TETS) is a potent convulsant poison that considered to be chemical threat agent. To provide basis for the investigation of antidotes TETS-induced seizures, we characterized activity TETS in mice and rats when administered by intraperitoneal, intravenous, oral, intraventricular routes as single acute dose with repeated sublethal doses. In mice, parenteral oral caused immobility, myoclonic body jerks, clonic seizures forelimbs and/or hindlimbs, tonic...