Alzheimer's disease is a complex and multifactorial neurodegenerative disease. Central administration of colchicine, microtubule-disrupting agent, causes loss cholinergic neurons cognitive dysfunction that associated with excessive free radical generation. The present study was aimed at evaluating the effects trans-resveratrol in prevention colchicine-induced impairment oxidative stress rats. Intracerebroventricular colchicine (15 microg/5 microl) induced impaired functions both Morris water...

Chronic fatigue syndrome (CFS) is an illness characterized by persistent and relapsing fatigue, often accompanied numerous symptoms involving various body systems. The etiology of CFS remains unclear; however, a number studies have shown that oxidative stress may be involved in its pathogenesis. In the present study, mouse model was used which mice were forced to swim for one 6-minute session on each day 15 days immobility period recorded. There significant increase saline-treated successive...

The present study investigated whether inhibition of fatty acid amide hydrolase (FAAH), the enzyme responsible for anandamide catabolism, produces antinociception in acetic acid-induced abdominal stretching model visceral nociception. Genetic deletion or pharmacological FAAH reduced stretching. Transgenic mice that express exclusively nervous system displayed antinociceptive phenotype, indicating involvement peripheral amides. cannabinoid receptor 1 (CB₁) antagonist, rimonabant,...

Although cannabinoids are efficacious in laboratory animal models of inflammatory pain, their established cannabimimetic actions diminish enthusiasm for therapeutic development. Conversely, fatty acid amide hydrolase (FAAH), the chief catabolic enzyme regulating endogenous cannabinoid <i>N</i>-arachidonoylethanolamine (anandamide), has emerged as an attractive target treating pain and other conditions. Here, we tested WIN 55212-2...

3-Nitropropionic acid (3-NP) is a well known fungic toxin causing neurotoxicity. Systemic administration of 3-NP causes motor and cognitive deficits that are associated with excessive free radical generation. Recently, curcumin has been implicated as neuroprotectant in the treatment various neurological disorders. The present study was designed to investigate effects 3-NP-induced impairment oxidative stress rats. Curcumin, potent antioxidant dietary polyphenol, containing standardized...

Abstract Systemic administration of 3‐nitropropionic acid (3‐NP), a complex II inhibitor the electron transport chain, causes motor and cognitive deficits that are associated with excitotoxicity excessive free radical generation. Recently, cyclooxygenase (COX) inhibitors have been implicated as neuroprotectant in treatment various neurological disorders. The present study was designed to investigate effects COX 3‐NP‐induced impairment oxidative stress rats. Intraperitoneal 3‐NP (20 mg/kg for...

Abstract Intracerebroventricular (i.c.v.) administration of colchicine, a microtubule‐disrupting agent, causes cognitive dysfunction and oxidative stress. The present study was designed to investigate the protective effects quercetin against colchicine‐induced memory impairment damage in rats. An i.c.v. cannula implanted lateral ventricle male Wistar Colchicine administered at dose 15 µg/rat. Morris water maze plus‐maze performance tests were used assess tasks. Various biochemical parameters...

Cognitive dysfunction, one of the most striking age-related impairments seen in human beings, has been correlated to vulnerability brain increased oxidative stress during aging process. Quercetin is a bioflavonoid with strong antioxidant properties. Experiments were performed study possible effects quercetin on cognitive performance young, aged or ethanol-intoxicated mice (an animal model for cognition dysfunction) using trail step down type passive avoidance and elevated plus maze tasks,...

Tardive dyskinesia (TD), a syndrome of potentially irreversible, involuntary hyperkinetic disorder occurring in 20–40% the patient population undergoing chronic neuroleptic treatment is major limitation therapy. Oxidative stress and products lipid peroxidation are implicated pathophysiology various neurological disorders including tardive dyskinesia. Chronic with neuroleptics leads to development abnormal oral movements rats known as vacuous chewing (VCMs). Vacuous widely accepted an animal...

Abstract Tardive dyskinesia is one of the major side effects long‐term neuroleptic treatment. The pathophysiology this disabling and commonly irreversible movement disorder still obscure. Vacuous chewing movements in rats are widely accepted as an animal model tardive dyskinesia. Oxidative stress products lipid peroxidation implicated Repeated treatment with reserpine (1.0 mg/kg) on alternate days for a period 5 (days 1, 3 5) signicantly induced vacuous tongue protrusions rats. Chronic...

We investigated the role of oxidative stress in pathophysiology haloperidol (HP)-induced orofacial dyskinesia and evaluated beneficial effect Withania somnifera (Ws) root extract amelioration HP-induced vacuous chewing movements (VCMs) tongue protrusions rat model for TD. Rats were treated 21 days with intraperitoneal HP (1 mg/kg); on day 22, VCMs counted during a 5-minute observation period. HP-treated rats significantly developed these extrapyramidal symptoms, but coadministration Ws...

Tardive dyskinesia (TD) is a serious neurological syndrome associated with long-term administration of neuroleptics to humans and experimental animals. The pathophysiology this disabling commonly irreversible movement disorder still obscure. It may be caused by loss dopaminergic cells or due free radicals as product high synaptic dopamine levels. Quercetin bioflavonoid strong antioxidant properties. Repeated treatment reserpine (1.0 mg/kg) on each other day for period 5 days (days 1, 3 5)...

Tardive dyskinesia (TD) is a serious motor side-effect of chronic neuroleptic therapy. Chronic treatment with neuroleptics leads to the development oral abnormal movements in rats known as vacuous chewing (VCMs). Vacuous have been widely accepted an animal model tardive dyskinesia. blockade D 2 inhibitory dopamine (DA) receptors localized on glutamatergic terminals striatum persistent enhanced release glutamate that kills striatal output neurons. The object present study was explore role...

This study was designed to investigate the protective effects of curcumin against colchicine-induced cognitive impairment and oxidative stress in rats. Male Wistar rats (weighing 150-200 g) received colchicine intracerebroventricularly (15 microg per rat), dysfunctions were evaluated by Morris water maze plus performance task supported biochemical tests. Central administration caused memory deficit both elevated paradigm tasks. Chronic treatment with (5-50 mg/kg, p.o.) twice daily for a...