A5055253078- Cannabis and Cannabinoid Research
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Lipoproteins and Cardiovascular Health
- Sleep and Wakefulness Research
- Cancer, Lipids, and Metabolism
- Receptor Mechanisms and Signaling
- Fatty Acid Research and Health
- Schizophrenia research and treatment
- Pancreatic function and diabetes
- SARS-CoV-2 and COVID-19 Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cholesterol and Lipid Metabolism
- Diabetes and associated disorders
- GABA and Rice Research
- Lipid metabolism and biosynthesis
- Diet and metabolism studies
- Healthcare cost, quality, practices
- Influenza Virus Research Studies
- Health Systems, Economic Evaluations, Quality of Life
- Tryptophan and brain disorders
- COVID-19 epidemiological studies
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Treatment and Research
- Adipose Tissue and Metabolism
Harvey Mudd College
2022
Medical Diagnostic Laboratories (United States)
2013-2019
University of Kansas Medical Center
2017-2018
University of California, San Diego
2016-2017
University of Richmond
2012-2015
University of Hertfordshire
2013
Virginia Commonwealth University
1998-2011
National White Collar Crime Center
2010
Bostwick Laboratories
2009
Urology Associates
2009
The endocannabinoid system has been proposed to modulate a variety of physiological processes, including those that underlie cognition. present study tested whether this is tonically active in learning and memory by comparing CB<sub>1</sub> receptor knockout mice (CB<sub>1</sub><sup>−/−</sup>) wild-type (CB<sub>1</sub><sup>+/+</sup>) several Morris water maze tasks. Also, the effects three cannabinoid agonists, Δ<sup>9</sup>-tetrahydrocannabinol...
Objective— Elevated lipoprotein(a) [Lp(a)] is a causal, independent risk factor for cardiovascular disease and aortic stenosis. We aimed to define the prevalence patient thresholds of elevated Lp(a) levels in United States. Approach Results— analyzed 532 359 subjects from 2 data sets: (1) 531 144 referral laboratory (2) 915 patients tertiary center. mass were measured by immunoturbidometric assays both centers expressed as mg/dL. At laboratory, median age (interquartile range) was 57.0...
The fatty acid (FA) composition of the red blood cell (RBC) has been reported to provide prognostic information regarding risk for coronary heart disease (CHD). In particular, Omega-3 Index (RBC eicosapentaenoic acid+docosahexaenoic acid, EPA+DHA) shown be independently and inversely related sudden cardiac death acute syndromes. Higher linoleic (n-6) lower trans FA levels have also associated with improved CHD outcomes. Accordingly, RBC panel recently introduced in routine clinical...
OBJECTIVE Latent autoimmune diabetes in adults (LADA) shares clinical features with both type 1 and 2 diabetes; however, there is ongoing debate regarding the precise definition of LADA. Understanding its genetic basis one potential strategy to gain insight into appropriate classification this subtype. RESEARCH DESIGN AND METHODS We performed first genome-wide association study LADA case subjects European ancestry versus population control (n = 2,634 vs. 5,947) compared against 2,454 968)...
Although it is widely accepted that Δ<sup>9</sup>-tetrahydrocannabinol (Δ<sup>9</sup>-THC) the primary psychoactive constituent of marijuana, questions persist as to whether other components contribute marijuana9s pharmacological activity. The present experiments assessed cannabinoid activity marijuana smoke exposure in mice and tested hypothesis Δ<sup>9</sup>-THC mediates these effects through a CB<sub>1</sub> receptor mechanism action. First, on analgesia, hypothermia, catalepsy were...
Omega-3 fatty acid (n-3 FA) biostatus can be estimated with red blood cell (RBC) membranes or plasma. The matrix that exhibits the lower within-person variability and is less affected by an acute dose of n-3 FA preferred in clinical practice.We compared effects a large on RBC plasma levels eicosapentaenoic (EPA) plus docosahexaenoic (DHA).Healthy volunteers (n = 20) were given 4 capsules containing 3.6 g standardized breakfast. Blood samples drawn at 0, 2, 4, 6, 8, 24 hours. EPA + DHA...
Lipoprotein(a) [Lp(a)] levels are genetically determined by hepatocyte apolipoprotein(a) synthesis, but catabolic pathways also influence circulating levels. APOE genotypes have different affinities for the low-density lipoprotein (LDL) receptor and LDL-related protein-1, with ε2 having weakest binding to LDL at <2% relative ε3 ε4. APPROACH AND RESULTS: (ε2/ε2, ε2/ε3, ε2/ε4, ε3/ε3, ε3/ε4, ε4/ε4), Lp(a) mass, directly measured Lp(a)-cholesterol levels, a variety of apoB-related lipoproteins...
To follow up in vitro evidence that Delta(9)-tetrahydrocannabivarin extracted from cannabis (eDelta(9)-THCV) is a CB(1) receptor antagonist by establishing whether synthetic (O-4394) and Delta(8)-tetrahydrocannabivarin (O-4395) behave as antagonists vivo.O-4394 O-4395 were compared with eDelta(9)-THCV displacers of [(3)H]-CP55940 specific binding sites on mouse brain membranes CP55940 [(35)S]GTPgammaS assays performed R-(+)-WIN55212 isolated vasa deferentia. Their ability to antagonize vivo...
Marijuana (<i>Cannabis sativa</i>) and its primary psychoactive component, δ-9-tetrahydrocannabinol (Δ<sup>9</sup>-THC), have long been known to disrupt cognition in humans. Although Δ<sup>9</sup>-THC other cannabinoids performance a wide range of animal models learning memory, few studies investigated the effects smoked marijuana these paradigms. Moreover, preclinical studies, are generally administered before acquisition, because retention is evaluated soon afterward, it difficult...
Circulating noncholesterol sterols/stanols (NCS) are used in clinical lipidology as surrogate measures of cholesterol synthesis and absorption, where they can be valuable tools assessing metabolism personalizing therapies patients with dyslipidemia.To describe the distributions plasma NCS concentrations inter-NCS correlations a large cohort American constituting laboratory database, to investigate relationship between circulating NCS, age, sex, apolipoprotein E (APOE) genotype.A total...
OBJECTIVE The MHC region harbors the strongest loci for latent autoimmune diabetes in adults (LADA); however, strength of association is likely attenuated compared with that childhood-onset type 1 diabetes. In this study, we recapitulate independent effects class I a population and then determine whether such conditioning LADA yields potential genetic discriminators between two subtypes within region. RESEARCH DESIGN AND METHODS Chromosome 6 was imputed using SNP2HLA, conditional analysis...
Although recent evidence suggests that fatty acid amide hydrolase (FAAH) may represent a potential therapeutic target, few published studies have investigated FAAH or its substrates (FAAs) in animal models of learning and memory. Therefore, our primary goal was to determine whether (–/–) mice, which possess elevated levels anandamide other FAAs, would display altered performance four Morris water maze tasks: acquisition hidden fixed platform, reversal learning, working memory, probe trials....
Objective Serum α-hydroxybutyrate (α-HB) is elevated in insulin resistance and diabetes. We tested the hypothesis that α-HB level predicts abnormal 1 h glucose levels β-cell dysfunction inferred from plasma kinetics during a 75 g oral tolerance test (OGTT). Research design methods This cross-sectional study included 217 patients at increased risk for OGTTs were performed with multiple postload measurements over 30–120 min period. OGTT responses analyzed by repeated measures analysis of...
Discordance between measures of atherogenic lipoprotein particle number (apolipoprotein B [ApoB] and low-density [LDL] by nuclear magnetic resonance spectroscopy [LDL-PNMR]) is not well understood. Appropriate treatment considerations in such cases are unclear.To assess discordance apoB determined immunoassay LDL-PNMR routine clinical practice, to characterize biomarker profiles other characteristics patients identified as discordant.Two retrospective cohorts were evaluated. First, 412,013...