A5072902888- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Advanced biosensing and bioanalysis techniques
- Medical Imaging Techniques and Applications
- Organoselenium and organotellurium chemistry
- Fluorine in Organic Chemistry
- Radiopharmaceutical Chemistry and Applications
- RNA Interference and Gene Delivery
- Chemical Synthesis and Reactions
- Sulfur-Based Synthesis Techniques
- Click Chemistry and Applications
- Amino Acid Enzymes and Metabolism
- Organic Chemistry Cycloaddition Reactions
- Plant and animal studies
- Synthesis and biological activity
- Catalytic C–H Functionalization Methods
- Supramolecular Chemistry and Complexes
- Synthesis and Characterization of Heterocyclic Compounds
- Axial and Atropisomeric Chirality Synthesis
- Synthesis and Catalytic Reactions
- Synthesis of Organic Compounds
- Biotin and Related Studies
- DNA and Nucleic Acid Chemistry
- Synthetic Organic Chemistry Methods
- Species Distribution and Climate Change
Biogen (United States)
2020-2024
Medicina
2021
Emory University
2017-2021
Sichuan University
2021
Technische Universität Braunschweig
2021
University of Oregon
2021
University of Messina
2021
Vrije Universiteit Brussel
2021
Massachusetts Institute of Technology
2021
Universidade Nova de Lisboa
2021
At 2.5 mol % loadings using reaction temperatures between 30-55 °C, ortho-functionalized diaryl diselenides are highly effective organocatalytic oxidants for aerobic redox dehydrative amidic and peptidic bond formation triethyl phosphite as a simple terminal reductant. This simple-to-perform relies on the ability of selenols to react directly with dioxygen in air without recourse metal catalysts. It represents an important step toward development general, economical, benign catalytic...
The synthesis of 1,4‐di‐ tert ‐butyl‐7‐R‐1,4,7‐triazacyclononane ( t Bu 2 Rtacn) derivatives through a “crab‐like” cyclization is reported. ‐butyl groups were cleavable with concentrated hydrochloric acid, allowing for facile and convenient the HCl salt H 3 tacn most direct route to its industrially relevant binucleating N ‐ethylene bridged derivative, 4 dtne. In addition, chiral both one two stereocenters in non‐annulet, alpha‐N positions
Abstract Questions How does the diversity of native, endemic and alien plant species, as well life forms, change during primary succession on lava flows an oceanic‐volcanic island? do environmental factors such moisture soil properties alter succession? Location La Palma, Canary Islands. Methods We recorded vascular plants bryophytes in 210 plots a chronosequence nine spanning approx. 6,000 years covering elevational range 1,100 m. In subset ( n = 78 plots) we collected analyzed samples for...
Oligonucleotides have emerged as valuable new therapeutics. Presently, oligonucleotide manufacturing consists in a series of stepwise additions until the full-length product is obtained. Deprotection phosphorus backbone before cleavage and deprotection (C&D) by ammonolysis necessary to control 3-(2-cyanoethyl) thymidine (CNET) impurity. In this study, we demonstrate that use piperazine scavenger acrylonitrile allows C&D be combined single step. This reduces solvent consumption, processing...
The non-natural cyclic amino acids (1S,3R,4S)-1-amino-3-fluoro-4-(fluoro-18F)cyclopentane-1-carboxylic acid ([18F]9) and (1S,3S,4R)-1-amino-3-fluoro-4-(fluoro-18F)cyclopentane-1-carboxylic ([18F]28) have been prepared in 10 1.7% decay corrected radiochemical yield, respectively, greater than 99% purity. Cell assays rat 9L gliosarcoma, human U87 ΔEGFR glioblastoma, DU145 androgen-independent prostate carcinoma tumor cells indicated that both compounds are substrates for transport primarily by...
The enantiomeric non-natural cyclic amino acids (3R,4R)-1-amino-3-fluoro-4-(fluoro-18F)cyclopentane-1-carboxylic acid and (3S,4S)-1-amino-3-fluoro-4-(fluoro-18F)cyclopentane-1-carboxylic ([18F]5) have been prepared as a racemic mixture in 1.3% decay corrected radiochemical yield greater than 99% purity. [18F]5 is transported primarily via system L with some transport occurring ASC, assessed rat 9L gliosarcoma, human U87 ΔEGFR glioblastoma, DU145 androgen-independent prostate carcinoma tumor...
Background: Natural products have been an exemplary source of new drugs as they served direct or indirect precursors for many currently available medicines. The natural product β -elemene has used clinically in the treatment various cancers; however, its efficacy is hampered by poor solubility and bioavailability. Methods: An aldehyde metabolite β-elemene, 13-β-elemenal, was further identified proved to exhibit significantly better anti-proliferative activity than -elemene. A series...
A systematic approach to the reduction and removal of each wash step in oligonucleotide synthesis was conducted, a critical analysis results this study is provided.
Ortho-functionalized aryl diselenides are catalytic (5.0 mol %) oxidants for the construction of esters from carboxylic acids and alcohols in presence stoichiometric triethyl phosphite dioxygen air as terminal redox reagents (redox dehydration conditions). The reaction proceeds through intermediacy anhydride requires 10% DMAP to drive esterification.
<b>Abstract ID 87749</b> <b>Poster Board 226</b> <b>Introduction:</b> Positron emission topography (PET) is often used as a non-invasive technique to evaluate drug distribution during preclinical and clinical studies. A positron emitter, such <sup>18</sup>F, incorporated into small-molecule drug, PET scan performed shortly after dosing measure various organs/tissues. This not amenable intrathecally injected ASO drugs treat neurological diseases, the within brain takes ∼24 hours, which beyond...
Abstract A simple, cost effective, and readily accessible apparatus for the photoisomerization of cis-cyclooctenes to trans-cyclooctenes is described. Utilizing only FEP tubing, aluminum vent pipe, a household germicidal lamp, flash chromatography system, can be prepared in good yield.
Abstract Density functional theory (DFT) calculations afforded insight into the origin of experimentally observed reaction rate acceleration (≥500 fold) and enantioselectivity (≥99 % ee) 1,1′‐bi‐2‐naphthol‐ (BINOL‐) catalyzed three‐component Petasis reactions . BINOL accelerates determining step by forming a B IV chelate, which involves loss water from hemiaminal moiety to generate an iminium intermediate. Subsequent vinyl group transfer carbon affords enantiomerically enriched product...
Rhodium-Catalyzed Direct Allylation of Simple Arenes by Using Gem-Difluorinated Cyclopropanes as Allyl Surrogates