Background Psychiatric illnesses are known risk factors for self-harm but associations between and physical less well established. We aimed to stratify selected chronic psychiatric according their relative of self-harm. Design Retrospective cohort studies using a linked dataset Hospital Episode Statistics (HES) 1999-2011. Participants Individuals with or conditions were compared reference constructed from patients admitted variety other procedures. Setting All admissions day cases in...

The neurofibromatoses (NF) are genetic disorders. Increased risks of some cancers in people with NF well recognised, but there is no comprehensive enumeration the across whole range site-specific cancers. Our aim was to provide this. A linked data set hospital admissions and deaths England used compare rates tumours an cohort a comparison cohort, results expressed as rate ratios (RR). RR for all combined, both types 4.3 (95% confidence interval (CI): 4.0–4.6), based on 769 cases cancer 8003...

<h3>Background</h3> People with severe mental illness have a higher risk than others of some physical diseases. The pneumococcal disease in people disorders is unknown. This potentially important because vaccines against the pneumococcus are available. <h3>Methods</h3> We used two datasets linked hospital admission and death records, Oxford Record Linkage Study all-England Hospital Episode Statistics, to estimate lobar pneumonia other (here, all collectively termed disease) hospitalised...

There are reports suggesting that people with Klinefelter's syndrome (KS) may be at increased risk of some autoimmune diseases, but the evidence is not substantial. We wanted to add by systematically assessing diseases in a national cohort KS. selected records all KS record-linked dataset hospital day cases and inpatient admissions England, 1999–2011; we followed them up electronic record linkage identify occurrence diseases. compared their control cohort, studied same way, expressed results...

Abstract Objectives To study trends in stroke mortality rates, event and case fatality, to explain the extent which reduction rates was influenced by changes or fatality. Design Population based study. Setting Person linked routine hospital data, England. Participants 795 869 adults aged 20 older who were admitted with acute died from stroke. Main outcome measures Stroke (stroke admission death without admission), fatality within 30 days after Results Between 2001 2010 decreased 55%, 20%,...

Objective. Some studies suggest that gout is a risk factor for cardiovascular disease. There more evidence about the association between and acute myocardial infarction (MI) than stroke, only limited information risks by age group sex. We aimed to study MI stroke following gout, including types of comparing men women.

Objective Case reports suggest that there may be an increased risk of some cancers associated with sickle cell disease. However, population-based studies are scarce and is no comprehensive enumeration the risks across whole range site-specific cancers. Our aim was to provide this. Design We used English national dataset linked statistical records hospital admissions deaths from 1999 2011 undertake a retrospective cohort study. Setting England. Participants Records all in England SCD or...

Young women with neurofibromatosis type 1 (NF1) are reported to have a higher risk of breast cancer than others, and this might implications for screening programmes. Our aim was calculate risk. An all-England linked data set hospital admissions deaths analysed determine age-specific rates in NF1 controls. The excess cancer, comparing the cohort control cohort, elevated 6.5-fold (95% confidence interval 2.6–13.5) aged 30–39 years. There 4.4 (2.5–7.0) times among 40–49. Women develop at...

BackgroundMyocardial infarction mortality has declined since the 1970s, but contemporary drivers of this trend remain unexplained. The aim study was to compare contribution trends in event rates and case fatality declines myocardial four high-income jurisdictions from 2002–15.MethodsLinked hospitalisation data were obtained New South Wales (NSW), Australia; Ontario, Canada; Zealand; England, UK. People aged between 30 years 105 included study. Age-adjusted estimated Poisson binomial...

Uric acid has antioxidant effects on neurons. Abnormally high levels of uric are, however, associated with gout. Previous studies have suggested that (and the presence gout) may exert a protective effect against risk developing some neurological diseases. We aimed to investigate this hypothesis in large database hospital admissions England.We analysed linked statistical records and death registrations England (1999-2012). A cohort people gout was constructed followed for development multiple...

Abstract Background Multiple sclerosis (MS) and epilepsy are both fairly common it follows that they may sometimes occur together in the same people by chance. We sought to determine whether hospitalisation for MS more often than expected chance alone. Methods analysed two datasets of linked statistical hospital admission records covering Oxford Record Linkage Study area (ORLS, 1963–1998) all England (1999–2011). In each, we calculated rate occurrence after MS, compared with equivalent rates...

<h3>Background</h3> There is increasing evidence that Turner syndrome associated with an elevated risk of a range autoimmune disorders. We aimed to document this in national study. <h3>Method</h3> Use record-linked dataset all hospital admissions England, 1999–2011, construct retrospective cohort people and control without it. Statistical follow-up identify the occurrence 29 separate disorders each cohort. Calculation rate ratios, comparing cohorts. <h3>Results</h3> In (2459 people), ratios...

Abstract Background The risk of invasive pneumococcal disease is higher in people with diabetes mellitus than those without. People should be considered for routine immunization. This policy has been place England more a decade. We aimed to estimate, at the population level, current scale excess patients diabetes, and whether risks have decreased recent years introduction vaccine. Methods used two data sets linked hospital admission death records—the Oxford Record Linkage Study (1963–1998)...

Subarachnoid hemorrhage (SAH) is a devastating cause of stroke, occurring in relatively young people. It has been suggested that some immune-mediated diseases may be associated with an increased risk SAH. We analysed database linked statistical records hospital admissions and death certificates for the whole England (1999–2011). Rate ratios SAH were determined, comparing disease cohorts comparison cohorts. There significantly elevated risks after admission following individual diseases:...

Patients with multiple sclerosis (MS) have been reported to be at higher risk of fracture than other people. We sought test this hypothesis in a large database hospital admissions England.We analysed linked statistical records and death certificates for the whole England (1999-2010). Rate ratios fractures were determined, comparing rates cohort all people admitted MS comparison cohort.Significantly elevated was found patients (rate ratio (RR) = 1.99, 95% confidence interval (CI) 1.93-2.05))....

Abstract Background Some studies report that women with anorexia nervosa (AN) have lower risk than others of breast cancer, but increased cancers other sites. No work has been done to quantify the in English population. Methods Retrospective cohort study using a national linked dataset Hospital Episode Statistics for 1999–2021. We selected individuals hospital admission AN, and compared their relative (RR) developing site‐specific cancers, reference cohort. Results identified 75 15,029...

Abstract Objective Anorexia nervosa (AN) and bulimia (BN) are eating disorders associated with high rates of self‐harm (SH). This is the first national study in England to quantify this association a hospital population. Method A retrospective cohort using linked dataset Hospital Episode Statistics for 1999–2021. The exposure included individuals aged &lt;35 years admitted diagnosis AN or BN. reference controls. We calculated rate ratio (RR) SH each cohort. two cohorts were matched on...

The COVID-19 pandemic has had a substantial impact on the film industry in 2020. Films that tell story of by giving independent commentaries are important to our understanding life during these rare public health events. However, it is unclear what effects would have production films. In this Letter we describe unique global collaboration saw launch an International Public Health Film Competition first wave early 2020 collect 'best health-related' stories told through film. We reflect...

There is a lack of information on changes in hospital admission rates for childhood-onset schizophrenia (COS), or patient characteristics, to inform clinical research and health service provision.To report age- sex-specific incidence admissions day care (ICD-10 F20) non-affective psychosis F20-29), by year occurrence age, childhood adolescence.Population-based study using person-linked data England (available 2001-2016); time-periods single years 4-year groups.Hospitalised increased with...

<ns4:p>The COVID CIRCLE initiative Research Project Tracker by UKCDR and GloPID-R associated living mapping review (LMR) showed the importance of sharing analysing data on research at point funding to improve coordination during a pandemic. This approach can also help with preparedness for outbreaks hence our new programme Pandemic Preparedness: Analytical Capacity Funding Tracking Programme (Pandemic PACT) has been established. The LMR described in this protocol will provide an open,...

This paper introduces the Pandemic PACT Advanced Categorisation Engine (PPACE) along with its associated dataset. PPACE is a fine-tuned model developed to automatically classify research abstracts from funded biomedical projects according WHO-aligned priorities. task crucial for monitoring trends and identifying gaps in global health preparedness response. Our approach builds on human-annotated projects, which are allocated one or more categories predefined list. A large language then used...

The COVID CIRCLE initiative Research Project Tracker by UKCDR and GloPID-R associated living mapping review (LMR) showed the importance of sharing analysing data on research at point funding to improve coordination during a pandemic. This approach can also help with preparedness for outbreaks hence our new programme Pandemic Preparedness: Analytical Capacity Funding Tracking Programme (Pandemic PACT) has been established. LMR described in this protocol builds previous COVID-19 database...