A5011465023- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- COVID-19 epidemiological studies
- Ethics in Business and Education
- SARS-CoV-2 detection and testing
- Viral gastroenteritis research and epidemiology
- Bacterial biofilms and quorum sensing
- Antibiotic Resistance in Bacteria
- Data-Driven Disease Surveillance
- Migraine and Headache Studies
- Parathyroid Disorders and Treatments
- Scientific Computing and Data Management
- Clostridium difficile and Clostridium perfringens research
- Neuroscience of respiration and sleep
- Bacterial Identification and Susceptibility Testing
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Research Data Management Practices
- Bioethics and Human Rights Issues
- Plant Virus Research Studies
- Public Health Policies and Education
- Mosquito-borne diseases and control
- vaccines and immunoinformatics approaches
- Ethics in Clinical Research
- Neonatal Health and Biochemistry
Public Health Wales
2019-2023
Genomics (United Kingdom)
2013-2023
National Institute for Health Research
2021-2022
University of Oxford
2013-2022
UK Research and Innovation
2021
MRC Biostatistics Unit
2021
Public Health England
2021
University of Cambridge
2021
Research Medical Center
2015-2021
Oxford Research Group
2021
Objectives.—Evidence‐based guidelines for the treatment of children with migraine are limited given paucity randomized controlled trials, especially in emergency department (ED). Our objectives were to: (1) characterize ED; (2) determine whether varies pediatric versus mixed (pediatric and adult) EDs. Methods.—Children aged 5 to 17 years presenting 4 regional departments Edmonton, Alberta, Canada during 2003/2004 fiscal year a diagnostic code headache or selected. A standardized...
Rising rates of multidrug-resistant Klebsiella infections necessitate a comprehensive understanding the major strains and plasmids driving spread resistance elements. Here, we analysed 540 clinical, screen environmental isolates recovered from across Wales between 2007 2020 using combined short- long-read sequencing approaches. We identified resistant clones that have within hospitals including high-risk strain sequence type (ST)307, which acquired bla OXA-244 carbapenemase gene on...
Subarachnoid hemorrhage (SAH) is a devastating cause of stroke, occurring in relatively young people. It has been suggested that some immune-mediated diseases may be associated with an increased risk SAH. We analysed database linked statistical records hospital admissions and death certificates for the whole England (1999–2011). Rate ratios SAH were determined, comparing disease cohorts comparison cohorts. There significantly elevated risks after admission following individual diseases:...
The importance of software to modern research is well understood, as the way in which developed for can support or undermine important principles findability, accessibility, interoperability, and reusability (FAIR). We propose a minimal subset common engineering that enable FAIRness computational be used baseline any discipline.
Abstract We present Global.health, a scalable online platform for collecting high-dimensional epidemiological data and transforming those into consistent schema to enable distributed analyses. Global.health was originally developed handle the demands of high-volume, accurate collection line list in early months COVID-19 pandemic. It has since proven amenable rapid adjustment as new variables became relevant, example tracking variants concern vaccination status cases, well clinical data. The...
While ethical principles like fairness and honesty may be broad cultural or even universal virtues, many inputs into a professional software engineer's code will situational, depending on the nature of employing institution line business in which that organisation participates. We compare published codes ethics for employees at Silicon Valley technology companies UK universities, to identify commonalities differences values guide engineering practice each category employer. This comparison...
OBJECTIVE: To investigate the association of morbidity and mortality in ischemic stroke patients with cerebral microbleed on magnetic resonance angiogram. BACKGROUND: Cerebral microbleeds might indicate a higher risk future intracerebral hemorrhage may be associated mortality.We investigated this study between increased it. DESIGN/METHODS: It9s retrospective which records from 580 were evaluated over 4 years. Patients strokes all ages who underwent imaging brain followed-up. RESULTS:...
Objectives: Evidence based guidelines for the treatment of children with migraine is limited given paucity randomized controlled trials. Our objectives were to: (1) characterize to identify areas clinical uncertainty in preparation future trials; (2) determine frequency narcotic use.
Background Guidance recommends the use of a two-stage algorithm for diagnosis Clostridioides difficile infection (CDI) utilising either PCR or glutamate dehydrogenase (GDH) assay as first line screen. There is ongoing debate to whether hindrance due fear over-diagnosis. Methods Between December 2017 and March 2019 over 65,000 tests CDI were undertaken in Wales. (Serosep EntericBio C. assay) was employed test 36% samples with remainder tested using GDH (Techlab diff ChekTM -60). Positive...
Background Clostridioides difficile infection (CDI) continues to cause significant morbidity and avoidable mortality worldwide. Results from an ultra-sensitive toxin immunoassay (Singlulex Clarity C. diff toxins A/B assay) were compared with those of various other diagnostic reference methods/algorithms for the detection . Methods 293 residual clinical stool samples tested using Singulex assay. In total, 188 by GDH 239 PCR. All B PCR (Serosep EntericBio positive (n=168) prospectively (n=97)...
Abstract Rising rates of multi-drug resistant Klebsiella infections necessitate a comprehensive understanding the major strains and plasmids driving spread resistance elements. Here we analysed 540 isolates recovered from patients across Wales between 2007 2020 using combined short- long-read sequencing approaches. We identified clones that have within hospitals including high-risk strain, sequence type (ST) 307, which acquired bla OXA-244 carbapenemase gene on pOXA-48-like plasmid. found...