A5040291244- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Reproductive tract infections research
- Viral gastroenteritis research and epidemiology
- Acute Myeloid Leukemia Research
- Influenza Virus Research Studies
- Escherichia coli research studies
- HIV Research and Treatment
- Animal Virus Infections Studies
- Monoclonal and Polyclonal Antibodies Research
- Herpesvirus Infections and Treatments
- Cervical Cancer and HPV Research
- Bacteriophages and microbial interactions
- Streptococcal Infections and Treatments
- Respiratory viral infections research
- Hepatitis B Virus Studies
- Virus-based gene therapy research
- Pneumonia and Respiratory Infections
- Viral Infections and Vectors
- Sarcoma Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Neonatal and Maternal Infections
- Pneumocystis jirovecii pneumonia detection and treatment
- vaccines and immunoinformatics approaches
- Advancements in Transdermal Drug Delivery
Epitaxial Technologies (United States)
2021-2024
Orano (United States)
2017
Colby Pharmaceutical (United States)
2013
Juvaris BioTherapeutics (United States)
2006-2011
Cincinnati Children's Hospital Medical Center
2009
University of Cincinnati
2009
The University of Texas MD Anderson Cancer Center
1994-2003
National Human Genome Research Institute
1998
National Institutes of Health
1998
University of Pennsylvania
1998
Abstract SARS-CoV-2 variants of concern (VOC) B.1.1.7 (alpha) and B.1.351 (beta) show increased transmissibility enhanced antibody neutralization resistance. Here we demonstrate in K18-hACE2 transgenic mice that are 100-fold more lethal than the original bearing 614D. cause severe organ lesions early strains 614D or 614G, with infection resulting distinct tissue-specific cytokine signatures, significant D-dimer depositions vital organs less pulmonary hypoxia signaling before death. However,...
Abstract Diarrhea caused by Shigella has been associated with high morbidity and mortality in young children worldwide. There are no licensed vaccines, those clinically advanced have restricted coverage as they elicit serotype-specific immunity while disease is multiple circulating serotypes. Our group had previously reported a close association between serum antibodies to the virulence factor VirG (or IcsA) clinical protection infected individuals. highly conserved among strains appealing...
Complete or partial deletions of the long arm chromosome 7 (7q- and -7) are nonrandom abnormalities seen in primary therapy-induced myelodysplasia (MDS) acute myelogenous leukemia (AML). Monosomy 7, occurring as sole cytogenetic anomaly a small but significant number cases, may denote dominant mechanism involving critical tumor suppressor gene(s). We have determined extent allele loss cytogenetically prescreened MDS AML patients for microsatellite markers from 7q22 7q31. Whereas >80%...
Despite widespread utilization of pneumococcal conjugate vaccines (PCVs) and the resultant disease reduction, development PCVs containing additional serotypes remains a public health priority due to serotype replacement shift non-vaccine serotypes. However, incorporating existing using conventional technologies has proven problematic. Immune responses individual have consistently decreased as more polysaccharide-conjugates are added carrier suppression. Using our proprietary cell-free...
Malaria, one of the most common vector borne human diseases, is a major world health issue. In 2015 alone, more than 200 million people were infected with malaria, out which, 429 000 died. Even though artemisinin-based combination therapies (ACT) are highly effective at treating malaria infections, novel efforts toward development vaccines to prevent transmission still needed. Pfs25, postfertilization stage parasite surface antigen, leading transmission-blocking vaccine (TBV) candidate. It...
Shigella is responsible for high burdens of diarrhea and dysentery globally. Children living in areas endemicity are the most affected, currently, there no licensed vaccines to prevent shigellosis. Vaccine approaches have traditionally targeted bacterial lipopolysaccharide as a protective antigen. O-polysaccharide (OPS) conjugated recombinant Pseudomonas aeruginosa exotoxin A (rEPA) or tetanus toxoid (TT) advanced clinical evaluation. Adequate efficacy these vaccines, particularly infant...
Despite current polysaccharide and conjugate vaccine use, pneumococcal diseases remain prevalent in older adults. VAX-24 is a 24-valent (PCV) containing eCRM, proprietary carrier protein with non-native amino acids (para-azidomethyl-L-phenylalanine) that undergo site-specific conjugation to polysaccharides have been activated small-molecule linker (dibenzocyclooctyne). Site-specific utilizing click chemistry enables consistent exposure of T-cell epitopes, reduction ratio, enhances...
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Dysentery caused by Shigella species remains a major health threat to children in low- and middle-income countries. There is no vaccine available. The most advanced candidates, i.e., O-polysaccharide (OPS)-based conjugates, have limited coverage—only against the immunizing serotype. Vaccines based on conserved proteins are sought for their simplicity capacity prevent disease multiple serotypes. We previously reported broad protective of VirGα, surface-exposed domain virulence factor. Seeking...
Acquired interstitial loss of all or part the long arm human chromosome 5 (5q-) is an anomaly that seen frequently in patients with preleukemic myelodysplasia and acute myelogenous leukemia. Loss a critical region overlap at band 5q31.1 these cases, various cytogenetic breaks, signifies existence key negative regulator leukemogenesis. Previous studies have defined proximal distal ends to reside between genes for IL9 EGR1, respectively. In this report, we describe yeast artificial contig...
Development of an effective vaccine against the leading human bacterial pathogen group A Streptococcus (GAS) is a public health priority. The species defining cell wall carbohydrate (GAC, Lancefield antigen) can be engineered to remove its immunodominant N-acetylglucosamine (GlcNAc) side chain, implicated in provoking autoimmune cross-reactivity rheumatic heart disease, leaving polyrhamnose core (GAC
Surface-expressed bacterial polysaccharides are important vaccine antigens but must be conjugated to a carrier protein for efficient antigen presentation and development of strong memory B cell antibody responses, especially in young children. The commonly used carriers include tetanus toxoid (TT), diphtheria (DT), its derivative CRM197, carrier-induced epitopic suppression bystander interference may limit the expanded use same pediatric immunization schedule. Recent efforts develop against...
Background. The decreased immune response among elderly individuals results in reduced influenza vaccine efficacy. Strategies to improve efficacy are needed. goal of this study was determine whether a cationic lipid/DNA complex (CLDC) can the trivalent inactivated Fluzone nonhuman primates.
is the second leading cause of diarrheal diseases, accounting for >200,000 infections and >50,000 deaths in children under 5 years age annually worldwide. The incidence
ABSTRACT The ViroSeq human immunodeficiency virus type 1 (HIV-1) genotyping system is an integrated for identification of drug resistance mutations in HIV-1 protease and reverse transcriptase (RT). Reagents are included sample preparation, transcription, PCR amplification, sequencing. Software provided to assemble edit sequence data generate a report. We determined the sensitivity specificity mutation detection using ABI PRISM 3100 genetic analyzer with set clinical samples recombinant...
AbstractThis pilot study tested the immunogenicity of a novel cationic liposome-DNA complex (CLDC) immunomodulatory vaccine adjuvant. Combined with specific antigen, CLDC enhanced anti-SIV immune responses induced by various SIV candidates. Rhesus macaques immunized in presence developed stronger SIV-specific T and B cell compared to animals without CLDC. These differences persisted resulted better memory after an in-vivo boost several months later whole AT-2 inactivated SIVmac239. Thus,...
Development of a herpes simplex virus (HSV) vaccine is priority because these infections are common. It appears that potent adjuvants will be required to augment the immune response subunit HSV vaccines. Therefore, we evaluated cationic liposome-DNA complexes (CLDC) as an adjuvant in mouse model genital herpes. Using whole-virus (HVAC), showed addition CLDC improved antibody responses compared alone. Most important, increased survival, reduced symptoms, and decreased vaginal replication...