A5102778169- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Coronary Interventions and Diagnostics
- Advanced X-ray and CT Imaging
- Nitric Oxide and Endothelin Effects
- Acute Myocardial Infarction Research
- Receptor Mechanisms and Signaling
- Cerebrovascular and Carotid Artery Diseases
- Ultrasound and Hyperthermia Applications
- Intracranial Aneurysms: Treatment and Complications
- Medical Imaging Techniques and Applications
- Congenital Heart Disease Studies
- Lanthanide and Transition Metal Complexes
- Cardiac Ischemia and Reperfusion
- Cardiomyopathy and Myosin Studies
- Heart Rate Variability and Autonomic Control
- Nanoparticle-Based Drug Delivery
- Gallbladder and Bile Duct Disorders
- Cardiac Valve Diseases and Treatments
- Renal and Vascular Pathologies
- Acute Ischemic Stroke Management
- Central Venous Catheters and Hemodialysis
- MRI in cancer diagnosis
- Mitochondrial Function and Pathology
Isle of Wight NHS Trust
2025
St. Mary’s Hospital
2025
University Hospitals of Morecambe Bay NHS Foundation Trust
2025
Royal Lancaster Infirmary
2025
First Affiliated Hospital of Dalian Medical University
2024
Dalian Medical University
2024
Hayatabad Medical Complex
2024
University of California, San Francisco
2011-2021
Berry (United States)
2011-2021
Philips (Germany)
2017
PURPOSE: To evaluate acute myocardial infarction by using first-pass enhancement (FPE) and delayed (DE) magnetic resonance (MR) imaging compared with thallium 201 (201Tl) single photon emission computed tomography (SPECT). MATERIALS AND METHODS: Contrast material–enhanced FPE MR, inversion-recovery DE rest-redistribution 201Tl SPECT images were obtained in 60 consecutive patients (53 men, seven women; mean age [± SD], 56 years ± 13; range, 30–78 years) at 6 days 3 after reperfused first...
PURPOSE: To estimate and compare the fractional distribution volume (fDV) of gadodiamide injection technetium 99m–diethylenetriaminepentaacetic acid (DTPA) in reperfused myocardium rat hearts subjected to various durations ischemia. MATERIALS AND METHODS: Magnetic resonance (MR) imaging autoradiography were performed rats 20, 30, 40, or 60 minutes regional ischemia followed by 1 hour reperfusion. The fDVs 99mTc-DTPA measured compared using inversion-recovery echo-planar autoradiographic...
Purpose: To prospectively evaluate the accuracy of clinical and cardiac magnetic resonance (MR) imaging parameters for predicting left ventricular (LV) remodeling by using follow-up as reference standard, to infarct resorption in patients with reperfused first myocardial infarcts. Materials Methods: The study was approved institutional ethics committee all gave written informed consent. In 55 (48 men, seven women; mean age ± standard deviation, 56 years 13), contrast material–enhanced cine...
Purpose To analyze the diagnostic accuracy of native T1 and T2 mapping compared with visual quantitative assessment edema on T2-weighted cardiac magnetic resonance (MR) images to differentiate between acute chronic myocardial infarction. Materials Methods This study had institutional ethics committee approval. Written informed consent was obtained from 67 consecutive patients (57 years ± 12; 78% men) a first infarction, who were prospectively enrolled April 2011 June 2015. Four serial 1.5-T...
Congenital central hypoventilation syndrome (CCHS) patients show deficient respiratory and cardiac responses to hypoxia hypercapnia, despite apparently intact arousal hypercapnia adequate motor mechanisms, thus providing a model evaluate functioning of particular brain mechanisms underlying breathing. We used functional magnetic resonance imaging assess blood oxygen level-dependent signals, corrected for global signal changes, evaluated them with cluster volume-of-interest procedures, during...
Abstract Introduction A Clinical Audit was recommended by the ME following identification of potential safety signal because possible non-compliance with guidelines on Anticoagulation in AF. The audit data collection tool developed discussion Chief Pharmacist and took account up-to-date prescribing guidance from Integrated Commissioning Board (ICB). Aim to identify if, as per NICE patients had: Objectives To ensure that new diagnosis atrial fibrillation are assessed for stroke bleeding...
Introduction: Spontaneous gallbladder perforation is a rare condition associated with high mortality. Case Report: We present case of 75-year-old woman presenting diarrhea, vomiting, and abdominal pain that began the same day. Her stools were loose, watery, brownish in color contained no blood or mucous. She vomited several times since morning her was mainly central not radiating anywhere. vitally stable moderately dehydrated on examination mild umbilical tenderness audible gut sounds....
This study was conducted to determine the effects of chronic pulmonary insufficiency (PI) on right (RV) and left (LV) ventricular function in young growing swine.Six PI 5 control animals were studied. induced by transcatheter placement stents across valve. Indices systolic (ejection fraction, cardiac output, functional reserve), diastolic (compliance), myocardial contractility (the slope relationship end-systolic pressure versus volume [Emax] dP/dtmax-end-diastolic [MdP/dt]) assessed within...
We tested whether the alpha 1- and 2-blocking agent phentolamine can be used to assess contribution of alpha-adrenergic constriction in circulatory control. In 15 conscious dogs at rest, (2 mg/kg i.v.) caused hypotension (-17 mm Hg mean arterial pressure), vasodilation (-29% total peripheral resistance), tachycardia, an increase cardiac output, oxygen consumption, plasma catecholamines. Following beta-adrenoceptor blockade i.v. nadolol), still produced increased catecholamine levels, but...
Delivery of resiniferatoxin under CT guidance around lumbar dorsal root ganglia in pigs resulted selective deletion nociceptive neurons and lasting analgesia.
To provide proof of concept that expansion myocardial extracellular volume (MECV), measured at contrast material-enhanced multidetector computed tomography (CT), can be used as a (a) marker for viability based on histologic confirmation and (b) predictor severity injury.Animals cared in compliance with Institutional Animal Care Use Committee served controls (group 1, n = 6) or were subjected to microinfarction by using 16-mm(3) (60 000 count) microemboli 2) 32-mm(3) (120 3), contiguous...
PURPOSE: To validate coronary sinus flow measurements for quantification of global left ventricular (LV) perfusion by means velocity-encoded cine (VEC) magnetic resonance (MR) imaging and probes. MATERIALS AND METHODS: Measurements were performed in seven dogs using VEC MR at baseline, single arterial stenosis, dipyridamole stress, reactive hyperemia. These compared with probe blood (CBF) the anterior descending (LAD) circumflex (CFX) arteries (CBFLAD+CFX) sinus. LV was calculated...
To use first-pass perfusion and delayed-enhanced (DE) magnetic resonance (MR) imaging for the detection of early effects coronary microembolization on myocardial viability.Approval was obtained from institutional committee animal research. A hybrid x-ray MR system used to guide endovascular catheter quantify left anterior descending artery (LAD) territory before ischemic myocardium microinfarction after microembolization. The embolic agent selectively delivered in LAD six pigs. First-pass...
The effects of lysolecithin (lysophosphatidylcholine) derived from egg yolk as well synthetic lysolecithins with different aliphatic chain lengths on tension development rabbit aortic strips were investigated. Lysolecithins caused slowly progressing, dose-dependent relaxation that was inhibited by hemoglobin, methylene blue, and nordihydroguiaretic acid. Indomethacin no inhibition relaxation. degree endothelium-dependent appeared to be related the activation guanylate cyclase [GTP...
Objectives: (1) To determine the accuracy of delayed enhancement multidetector computed tomography (MDCT) in measuring extent acute myocardial infarct and no-reflow areas using cardiac magnetic resonance imaging (MRI) as standard reference (2) to define optimum timing between injection MDCT image acquisition characterize infarcted myocardium after reperfusion therapy. Materials Methods: Nineteen patients were prospectively included infarction revascularization. Each patient had an before 5...
Background Patients with endovascular stent implantation for the treatment of right ventricular outflow tract obstruction are often left incomplete relief and significant pulmonary regurgitation. A noninvasive reproducible method monitoring such patients is desirable. MRI in presence a stent, however, has to overcome problem potential metallic artifacts. Methods Results Under x-ray fluoroscopic guidance, nitinol stents were placed across valve 6 young pigs induce Five additional served as...
Purpose: To prospectively investigate the long-term effect of adeno-associated viral (AAV) vector–encoding vascular endothelial growth factor gene (VEGF) (AAV-VEGF) on left ventricular (LV) mass and volumes, as well regional contractility circumferential strain, in a swine model reperfused myocardial infarction. Materials Methods: All experimental procedures received approval from institutional committee animal research. Of 16 pigs subjected to infarction, six were treated, controls, four...
Purpose: To prospectively determine in swine the effects of cardiac-specific and hypoxia-inducible vascular endothelial growth factor (VEGF) expression gene on angiogenesis arteriogenesis by using cardiovascular magnetic resonance (MR) imaging for evaluation infarct resorption left ventricular (LV) function. Materials Methods: The investigation conformed to U.S. National Institutes Health guidelines. Twelve pigs with reperfused infarcts were studied MR 3 days 8 weeks after surgery. In six...
Abstract Purpose To quantitatively assess atrial septal defects (ASDs) with small shunts using MRI followed by transcatheter closure monitored MR fluoroscopy. Materials and Methods Acute ASDs were created in 14 pigs under x‐ray Six animals studied order to select MR‐compatible delivery systems imaging strategies. eight examined balloon sizing fluoroscopy, flow measurements, contrast media injections, after which was performed The system assembled from commercially available materials....