A5088260070- High Altitude and Hypoxia
- Neuroscience of respiration and sleep
- Cancer, Hypoxia, and Metabolism
- Cardiovascular and Diving-Related Complications
- Hemoglobin structure and function
- Biochemical Analysis and Sensing Techniques
- Circadian rhythm and melatonin
- Biochemical effects in animals
- Sleep and Wakefulness Research
- Mitochondrial Function and Pathology
Hospital Universitario Virgen del Rocío
2018-2025
Instituto de Biomedicina de Sevilla
2018-2025
Universidad de Sevilla
2018-2025
Biomedical Research Networking Center on Neurodegenerative Diseases
2018
Abstract Classically considered a by-product of anaerobic metabolism, lactate is now viewed as fundamental fuel for oxidative phosphorylation in mitochondria, and preferred over glucose by many tissues. Lactate also signaling molecule increasing medical relevance. levels the blood can increase both normal pathophysiological conditions (e.g., hypoxia, physical exercise, or sepsis), however manner which these changes are sensed induce adaptive responses unknown. Here we show that carotid body...
Mammalian adaptation to oxygen flux occurs at many levels, from shifts in cellular metabolism physiological adaptations facilitated by the sympathetic nervous system and carotid body (CB). Interactions between differing forms of adaptive response hypoxia, including transcriptional responses orchestrated Hypoxia Inducible transcription Factors (HIFs), are complex clearly synergistic. We show here that there is an absolute developmental requirement for HIF-2α, one HIF isoforms, growth survival...
Abstract The carotid body (CB) is the main oxygen (O 2 ) sensing organ that mediates reflex hyperventilation and increased cardiac output in response to hypoxaemia. Acute O an intrinsic property of CB glomus cells, which contain special mitochondria generate signalling molecules (NADH H modulate membrane K + channels lowered tension (hypoxia). In parallel with these membrane‐associated events, cells are highly sensitive mitochondrial electron transport chain (ETC) inhibitors. It was...
The sex hormones progesterone (P) and oestrogen (E) reorganize GABAergic transmission in the prefrontal cortex (PFC) during transition from childhood to adolescence, generating a new excitatory-inhibitory balance necessary for computational capacity of mature PFC. Little is known, however, about hormone receptors involved or whether there are differences modulation they exert. We hypothesize that P E can rapidly (within minutes) modulate currents through G protein-coupled receptors, namely...
Summary Mammalian adaptation to oxygen flux occurs at many levels, from shifts in cellular metabolism physiological adaptations facilitated by the sympathetic nervous system and carotid body (CB). Interactions between differing forms of adaptive response hypoxia, including transcriptional responses orchestrated Hypoxia Inducible transcription Factors (HIFs), are complex clearly synergistic. We show here that there is an absolute developmental requirement for HIF-2a, one HIF isoforms, growth...