A5059334860- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience of respiration and sleep
- Autism Spectrum Disorder Research
- High Altitude and Hypoxia
- Hemoglobin structure and function
- Mitochondrial Function and Pathology
- Liver Disease and Transplantation
- Liver physiology and pathology
- Educational Outcomes and Influences
- Liver Disease Diagnosis and Treatment
- Nerve injury and regeneration
Universidad de Sevilla
2025
Instituto de Biomedicina de Sevilla
2025
Biomedical Research Networking Center on Neurodegenerative Diseases
2025
Hospital Universitario Virgen del Rocío
2025
Institut d'Investigacions Biomèdiques de Barcelona
2021-2022
Consejo Superior de Investigaciones Científicas
2021-2022
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2021
ORCID
2021
Universidad de Granada
1996
Abstract Anxiety and depression affect 35–50% of patients with Parkinson’s disease (PD), often precede the onset motor symptoms, have a negative impact on their quality life. Dysfunction serotonergic (5-HT) system, which regulates mood emotional pathways, occurs during premotor phase PD contributes to variety non-motor symptoms. Furthermore, α-synuclein (α-Syn) aggregates were identified in raphe nuclei early stages disease. However, there are very few animal models PD-related...
Abstract The carotid body (CB) is the main oxygen (O 2 ) sensing organ that mediates reflex hyperventilation and increased cardiac output in response to hypoxaemia. Acute O an intrinsic property of CB glomus cells, which contain special mitochondria generate signalling molecules (NADH H modulate membrane K + channels lowered tension (hypoxia). In parallel with these membrane‐associated events, cells are highly sensitive mitochondrial electron transport chain (ETC) inhibitors. It was...
Carotid body glomus cells are essential for stimulating breathing in response to hypoxia. They contain specialized mitochondria which hypoxia induces the accumulation of NADH and H 2 O that modulate membrane ion channel activity. We investigated whether reverse electron transport (RET) at mitochondrial complex I (MCI). studied from mice with a mutation ND6, core protein MCI, maintain normal MCI dehydrogenase activity but cannot catalyze RET. The ND6 increases propensity deactivate,...
Anxiety and depression are common in Parkinson's disease (PD), affecting quality of life. Aggregates α-synuclein (α-Syn) found serotonergic (5-HT) raphe nuclei early the disease, but their relationship to brain changes is unclear. We investigated synaptic plasticity, neuronal activity, functional magnetic resonance imaging (fMRI)-based connectivity a PD-like mouse model with depressive phenotype. AAV-induced human α-Syn accumulation 5-HT neurons causes progressive pathology interconnected...
α-Synuclein (α-Syn) protein is involved in the pathogenesis of Parkinson’s disease (PD). Point mutations and multiplications α-Syn, which encodes SNCA gene, are correlated with early-onset PD, therefore reduction a-Syn synthesis could be a potential therapy for PD if delivered to key affected neurons. Several experimental strategies have been developed recent years using oligonucleotide therapeutics. However, some them failed or even caused neuronal toxicity. One limiting step success...
Intake of thioacetamide in drinking water causes liver cirrhosis rats, which exhibit many changes similar to human disease. Nucleotides play an important part major cellular functions, and recent studies suggest that dietary nucleotides may be considered 9semi-essential9 nutrients situations when inadequate supply affect the growth tissues with a rapid turnover rate. The aim this study was assess effect on lesions thioacetamide-cirrhotic calculate proportion mono binucleated hepatocytes...
La fortaleza y la confianza en sí mismo son el principal factor o aspecto que beneficia resiliencia. El objetivo de investigación es analizar dimensión relación con resiliencia del estudiantado TecNM campus Tierra Blanca, Veracruz, México, mediante cuestionario RESI-M (Escala Mexicana Resiliencia). Se realizó una enfoque cuantitativo no experimental (observacional), bajo un estudio descriptivo, correlacional, comparativo corte transversal utilizó muestra 161 estudiantes Campus Blanca a los...
Abstract Anxiety and depression affect 35–50% of patients with Parkinson's disease (PD), often precede the onset motor symptoms, have a negative impact on their quality life. Dysfunction serotonergic (5-HT) system, which regulates mood emotional pathways, occurs during premotor phase PD contributes to variety non-motor symptoms. Furthermore, α-synuclein (α-Syn) aggregates were identified in raphe nuclei early stages disease. However, there are very few animal models PD-related...