John R. Best

ORCID: 0000-0001-5775-7053
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About
Contact & Profiles
Research Areas
  • Dementia and Cognitive Impairment Research
  • Stroke Rehabilitation and Recovery
  • Obsessive-Compulsive Spectrum Disorders
  • Health disparities and outcomes
  • Balance, Gait, and Falls Prevention
  • Eating Disorders and Behaviors
  • Functional Brain Connectivity Studies
  • Autism Spectrum Disorder Research
  • Sleep and related disorders
  • Physical Activity and Health
  • Obesity, Physical Activity, Diet
  • Cognitive Abilities and Testing
  • Frailty in Older Adults
  • Advanced Neuroimaging Techniques and Applications
  • Health Systems, Economic Evaluations, Quality of Life
  • Cerebrovascular and Carotid Artery Diseases
  • Cerebral Palsy and Movement Disorders
  • Cardiovascular Health and Disease Prevention
  • HIV/AIDS Research and Interventions
  • Acute Ischemic Stroke Management
  • Sleep and Wakefulness Research
  • Health, Environment, Cognitive Aging
  • COVID-19 and Mental Health
  • Behavioral Health and Interventions
  • Aging and Gerontology Research

Simon Fraser University
2020-2024

University of British Columbia
2015-2024

British Columbia Children's Hospital
2019-2024

Vancouver Coastal Health Research Institute
2015-2023

Vancouver Coastal Health
2015-2023

British Columbia Centre of Excellence for Women's Health
2017-2022

BC Mental Health & Substance Use Services
2022

PerkinElmer (United States)
2022

Haukeland University Hospital
2022

Amsterdam Neuroscience
2022

Sleep quality decreases with aging and thus sleep complaints are prevalent in older adults, particularly for those cognitive impairment dementia. For emerging evidence suggests poor increases risk of developing Given the population – impending economic burden associated increasing numbers dementia patients there is pressing need to improve among adults. As such, research efforts have increased focus on investigating association between age-related changes decline a complex construct evaluate...

10.3389/fnagi.2015.00166 article EN cc-by Frontiers in Aging Neuroscience 2015-09-07

<h3>Importance</h3> Whether exercise reduces subsequent falls in high-risk older adults who have already experienced a fall is unknown. <h3>Objective</h3> To assess the effect of home-based program as prevention strategy were referred to clinic after an index fall. <h3>Design, Setting, and Participants</h3> A 12-month, single-blind, randomized clinical trial conducted from April 22, 2009, June 5, 2018, among aged at least 70 years had within past 12 months recruited clinic....

10.1001/jama.2019.5795 article EN JAMA 2019-06-04

The current study examined an important aspect of experience--physical activity--that may contribute to children's executive function. design attempted tease apart 2 aspects exercise by examining the separate and combined effects acute physical activity cognitive engagement on functioning. In a × within-subject experimental design, children (N = 33, 6 10 years old) completed activities that varied systematically in both (physically active video games versus sedentary activities) (challenging...

10.1037/a0026648 article EN Developmental Psychology 2011-12-12

Abstract Aerobic exercise training has been shown to attenuate cognitive decline and reduce brain atrophy with advancing age. The extent which resistance improves cognition prevents is less known, few studies include long-term follow-up neuroimaging assessments. We report data from a randomized controlled trial of 155 older women, who engaged in 52 weeks (either once- or twice-weekly) balance-and-toning (twice-weekly). Executive functioning memory were assessed at baseline, 1-year (i.e.,...

10.1017/s1355617715000673 article EN Journal of the International Neuropsychological Society 2015-11-01

Background Vascular cognitive impairment (VCI) results from cerebrovascular disease, and worldwide, it is the second most common type of dysfunction. While targeted aerobic training a promising approach to delay progression VCI by reducing cardiometabolic risk factors, few randomised controlled trials date have specifically assessed efficacy on brain outcomes in this group at for functional decline. Aim To examine effect moderate-intensity executive functions neural activity among older...

10.1136/bjsports-2016-096846 article EN British Journal of Sports Medicine 2017-04-21

Our goal was to determine whether behavioral economic constructs-including impulsivity (i.e., steep discounting of delayed food and monetary rewards), the relative reinforcing value (RRVfood), environmental enrichment presence alternatives unhealthy foods in home neighborhood environments)-are significant pretreatment predictors overweight children's weight loss within family-based treatment.Overweight children (N = 241; ages 7-12 years; 63% female; 65% non-Hispanic White) enrolled a 16-week...

10.1037/a0029827 article EN Journal of Consulting and Clinical Psychology 2012-08-27

To assess the efficacy of a progressive aerobic exercise training program on cognitive and everyday function among adults with mild subcortical ischemic vascular impairment (SIVCI).This was proof-of-concept single-blind randomized controlled trial comparing 6-month, thrice-weekly, (AT) usual care plus education follow-up assessment 6 months after formal cessation training. Primary outcomes assessed were general (Alzheimer's Disease Assessment Scale-Cognitive subscale [ADAS-Cog]), executive...

10.1212/wnl.0000000000003332 article EN Neurology 2016-10-20

Few cohort studies have examined longitudinal associations between age-related changes in cognition and physical performance. Further, whether these differ for men versus women or can be attributed to differences activity (PA) is unknown. Participants were 2,876 initially well-functioning community-dwelling older adults (aged 70–79 years at baseline; 52% female; 39% black) studied over a 9-year period. Usual gait speed, self-reported PA, two cognitive measures—Digit Symbol Substitution Test...

10.1093/gerona/glw066 article EN The Journals of Gerontology Series A 2016-04-10

Previous studies have shown that exercise training benefits cognitive, neural, and physical health markers in older adults. It is likely these positive effects will diminish if participants return to sedentary lifestyles following cessation. Theory posits the neurocognitive processes underlying self-regulation, namely executive function (EF), are important maintaining behaviors. Therefore, we examined whether better EF performance women would predict greater adherence routine activity (PA)...

10.3389/fnhum.2014.00353 article EN cc-by Frontiers in Human Neuroscience 2014-05-27

Mild cognitive impairment (MCI) represents a transition between normal aging and dementia may represent critical time frame for promoting health through behavioral strategies. Current evidence suggests that physical activity (PA) sedentary behavior are important cognition. However, it is unclear whether there differences in PA people with probable MCI without or the relationships of function differ by status.The aims this study were to examine associations differed status.This was...

10.1093/ptj/pzx074 article EN Physical Therapy 2017-07-17

Older adults with mobility impairments are prone to reduced health related quality of life (HRQoL) is highly associated impairments. The consequences falls have detrimental impact on mobility. Hence, ascertaining factors explaining variation among individuals' critical for promoting healthy ageing, particularly older fallers. the primary objective our study was identify key that explain in HRQoL community dwelling at risk falls. We conducted a longitudinal analysis 12-month prospective...

10.1186/s12955-015-0299-0 article EN cc-by Health and Quality of Life Outcomes 2015-07-14

The primary objective was to determine whether children and their participating parents undergoing family-based behavioral treatment (FBT) for obesity show similar dietary changes following treatment, if so, these shared explain the similarity in weight change within parent-child dyad.Data come from a randomized controlled trial of 148 dyads who completed FBT were followed over 2-year maintenance phase. Energy-dense, nutrient-poor foods ("RED" foods) fruit vegetable intake assessed across...

10.1037/hea0000247 article EN other-oa Health Psychology 2015-07-20

Exergaming (a portmanteau of "exercise" and "gaming") is a relatively new genre interactive video gaming that stimulates an active, whole-body experience. could have significant positive impact on youth as across the globe are living more sedentary lifestyles. has potential to thwart this trend by engaging in physical activity (PA). not only physically-engaging but also cognitively-engaging, combination cognitive engagement may translate into improved function youth. The purpose review...

10.1027/2151-2604/a000137 article EN Zeitschrift für Psychologie 2013-01-01

Elucidation of optimal dosing and treatment content is critical for health care providers, payers, policy makers, as well mechanisms change to inform intervention delivery training initiatives childhood obesity.

10.1001/jamapediatrics.2017.2960 article EN JAMA Pediatrics 2017-10-30

Ascertaining individuals’ quality of life and wellbeing is essential in public health clinical research. The impact these two pressing geriatric syndromes – impaired mobility cognitive function -- on not well examined. Hence, our objective was to identify key clinically relevant outcome measures that explain variation related (HRQoL) among community dwelling older adults. We conducted a cross-sectional analysis 229 participants presenting the Vancouver Falls Prevention Clinic from June 2010...

10.1186/s12877-015-0076-2 article EN cc-by BMC Geriatrics 2015-07-04

Aerobic training (AT) is a promising, non-pharmacological intervention to mitigate the deleterious effects of aging and disease on brain health. However, large amount variation exists in its efficacy. This secondary analysis randomized controlled trial AT 71 older adults with s ubcortical ischemic vascular cognitive impairment (NCT01027858). Specifically, we investigated: 1) whether sex moderates relationship between executive functions, 2) role derived neurotrophic factor (BDNF) gains...

10.3233/jad-170221 article EN Journal of Alzheimer s Disease 2017-10-13

Aging is characterized by cognitive changes in specific domains, such as declines memory and executive functions. Given the world's aging population, it important to identify evaluate strategies that promote healthy aging. Besides exercise, computerized training (CCT) a promising approach function. Moreover, single bout of exercise immediately prior CCT may provide additional benefits. An 8-week proof-of-concept randomized controlled trial investigate effect commercial intervention, alone...

10.1093/gerona/glz115 article EN The Journals of Gerontology Series A 2019-05-04
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