A5034947123- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Infant Nutrition and Health
- COVID-19 Impact on Reproduction
- Immune responses and vaccinations
- Animal Virus Infections Studies
- interferon and immune responses
- RNA regulation and disease
- Mosquito-borne diseases and control
- Influenza Virus Research Studies
- Digestive system and related health
- Mitochondrial Function and Pathology
- CAR-T cell therapy research
- Virus-based gene therapy research
- Pediatric health and respiratory diseases
- Synthesis and Biological Evaluation
- Clinical Nutrition and Gastroenterology
- RNA Research and Splicing
- Immune Cell Function and Interaction
- Cancer Research and Treatments
- Neonatal Respiratory Health Research
- Cytomegalovirus and herpesvirus research
- RNA and protein synthesis mechanisms
Amsterdam University Medical Centers
2020-2024
University of Amsterdam
2020-2024
Emma Kinderziekenhuis
2020-2024
Amsterdam UMC Location University of Amsterdam
2020-2024
Picornaviruses are a leading cause of central nervous system (CNS) infections. While genotypes such as parechovirus A3 (PeV-A3) and echovirus 11 (E11) can elicit severe neurological disease, the highly prevalent PeV-A1 is not associated with CNS disease. Here, we expand our current understanding these differences in PeV-A disease using human brain organoids clinical isolates two genotypes. Our data indicate that specific due to infectivity cells both viruses productively infect similar cell...
Enterovirus A71 (EV-A71) can elicit a wide variety of human diseases such as hand, foot, and mouth disease severe or fatal neurological complications. It is not clearly understood what determines the virulence fitness EV-A71. has been observed that amino acid changes in receptor binding protein, VP1, resulting viral to heparan sulfate proteoglycans (HSPGs) may be important for ability EV-A71 infect neuronal tissue. In this study, we identified presence glutamine, opposed glutamic acid, at...
Human milk is important for antimicrobial defense in infants and has well demonstrated antiviral activity. We evaluated the protective ability of human against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection a fetal intestinal cell culture model. found that, this model, blocks SARS-CoV-2 replication, irrespective presence spike-specific antibodies. Complete inhibition both enveloped Middle East syncytial virus infections was also observed, whereas no non-enveloped...
Human parechovirus (PeV-A), one of the species within
Halofuginone hydrobromide has shown potent antiviral efficacy against a variety of viruses such as SARS-CoV-2, dengue, or chikungunya virus, and has, therefore, been hypothesized to have broad-spectrum activity. In this paper, we tested activity hydrobomide from different families (Picornaviridae, Herpesviridae, Orthomyxoviridae, Coronaviridae, Flaviviridae). To end, used relevant human models the airway intestinal epithelium regionalized neural organoids. showed SARS-CoV-2 in with no...
The prognosis for triple-negative breast cancer (TNBC) and pancreatic ductal adenocarcinoma (PDAC) is dismal. TNBC PDAC are highly aggressive cancers with few treatment options a potential rapid resistance to standard-of-care chemotherapeutics. Oncolytic adenoviruses (OAds) represent promising tumour-selective strategy that can overcome eliminate cells by lysis host immune activation. We demonstrate histone deacetylase inhibitors (HDACi) potently enhanced the cancer-cell killing of our OAds,...
Summary Parechovirus ahumpari 3 (HPeV-3) , is among the main agents causing severe neonatal neurological infections such as encephalitis and meningitis. However, underlying molecular mechanisms changes to host cellular landscape leading disease has been understudied. Through quantitative proteomic analysis of HPeV-3 infected neural organoids, we identified unique metabolic following infection that indicate immunometabolic dysregulation. Protein pathway analyses showed significant alterations...
Abstract Parechovirus A (PeV-A) is a species in the Picornaviridae family that can cause variety of diseases, mainly children.The most prevalent genotype, PeV-A1, causes mild respiratory and gastrointestinal symptoms while second PeV-A3 elicit severe neurological disease such as meningoencephalitis infants. The factors determining differential outcomes between genotypes are poorly understood. In this study, we investigated viral dynamics tropism PeV-A1 infection human induced pluripotent...
Abstract Picornaviruses are a leading cause of central nervous system (CNS) infections. While genotypes such as Parechovirus A3 (PeV-A3) and echovirus 11 (E11) can elicit severe neurological disease, the highly prevalent PeV-A1 is not associated with CNS disease. Here, we expand our current understanding these differences in PeV-A disease using human brain organoids clinical isolates genotypes. Our data indicates that specific due to infectivity cells both viruses productively infect similar...
Abstract Halofuginone hydrobromide has shown potent antiviral efficacy against a variety of viruses such as SARS-CoV-2, dengue, or chikungunya virus, and has, therefore, been hypothesized to have broad-spectrum activity. In this paper, we tested activity hydrobomide from different families ( Picornaviridae, Herpesviridae, Orthomyxoviridae, Coronaviridae, Flaviviridae). To end, used relevant human models the airway intestinal epithelium regionalised neural organoids. showed SARS-CoV-2 in with...
Halofuginone hydrobromide has shown potent antiviral efficacy against a variety of viruses such as SARS-CoV-2, dengue, or chikungunya virus, and has, therefore, been hypothesized to have broad-spectrum activity. In this paper, we tested activity hydrobomide from different families (Picornaviridae, Herpesviridae, Orthomyxoviridae, Coronaviridae, Flaviviridae). To end, used relevant human models the airway intestinal epithelium regionalised neural organoids. showed SARS-CoV-2 in with no...