A5010795911- Nuclear Structure and Function
- Cellular Mechanics and Interactions
- Advanced Sensor and Energy Harvesting Materials
- Skin and Cellular Biology Research
- RNA Research and Splicing
- Micro and Nano Robotics
- Advanced Chemical Sensor Technologies
- Analytical Chemistry and Sensors
- Dye analysis and toxicity
- Neuroscience and Neural Engineering
- Extracellular vesicles in disease
- Heavy Metal Exposure and Toxicity
- Reproductive Physiology in Livestock
- Hydrogels: synthesis, properties, applications
- Medication Adherence and Compliance
- Muscle metabolism and nutrition
- 3D Printing in Biomedical Research
- Dermatology and Skin Diseases
- Genomics and Chromatin Dynamics
- Colorectal and Anal Carcinomas
- Gas Sensing Nanomaterials and Sensors
- Cardiomyopathy and Myosin Studies
- Cell Adhesion Molecules Research
- Pharmacological Effects of Natural Compounds
- Natural Antidiabetic Agents Studies
University of California, San Diego
2020-2024
University of Baghdad
2020-2022
University of Pennsylvania
2017-2019
University of San Francisco
2017
The use of micromotors for active drug delivery via oral administration has recently gained considerable interest. However, efficient motor-assisted into the gastrointestinal (GI) tract remains challenging, owing to short propulsion lifetime currently used micromotor platforms. Here, we report on an algae-based motor platform, which takes advantage fast and long-lasting swimming behavior natural microalgae in intestinal fluid prolong local retention within GI tract. Fluorescent dye or cell...
Ketone bodies (KBs), especially β-hydroxybutyrate (BHB), have gained tremendous attention as potential biomarkers their presence in bodily fluids is closely associated with health and wellness. While a variety of blood fingerstick test strips are available for self-testing BHB, there major needs wearable devices capable continuously tracking changing BHB concentrations. To address these needs, we present here the first demonstration microneedle-based continuous ketone monitoring (CKM) human...
Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia due to persistent insulin resistance, resulting in elevated blood glucose levels. Metformin the most prescribed oral drug for lowering high levels T2DM patients. However, it poorly absorbed and has low bioavailability. Here, we introduce magnesium-based microstirrers a metformin-containing pill matrix enhance glucose-lowering effect of metformin. The microstirring possesses built-in mixing capability creating local fluid...
Interphase phosphorylation of lamin-A,C depends dynamically on a cell's microenvironment, including the stiffness extracellular matrix. However, dynamics is poorly understood for diseased forms such as progerin, permanently farnesylated mutant LMNA that accelerates aging stiff and mechanically stressed tissues. Here, fine-excision alignment mass spectrometry (FEA-MS) developed to quantify progerin its levels in patient iPS cells differentiated mesenchymal stem (MSCs). The stoichiometry total...
Abstract Here the fabrication of a zinc (Zn) microrocket pill is reported, and its unique features toward active enhanced oral delivery application are demonstrated. By loading Zn‐based tubular microrockets into an orally administrable formulation, resulting Zn can rapidly dissolve in stomach, releasing numerous encapsulated that instantaneously activated then propel gastric fluid. The released display efficient propulsion without being affected by presence inactive excipient materials pill....
CD63 is -one of the tetraspanin family proteins, which are regarded as: hallmark exosomal markers because it absent from other types vesicles. It expressed in cell membrane cancer cells, and cytoplasm stromal cells. Objective: To assess expression gastric (GC) patients, detected if could be used as a predictive marker. Furthermore, current study aimed to find correlation between clinicopathological parameters gender, age, invasion depth, histopathological type, involvement lymph nodes, grade...
PARP-1 is a protein enzyme with major role in DNA repair that overexpressed many malignancies. It correlated susceptibility and metastasis to lymph nodes gastric cancer (GC). The objective of the present investigation estimate PARP1 expression patients detected if it could be used as predictive marker. Furthermore, we aimed find correlation between clinicopathological parameters, such gender, age, invasion depth, histopathological type, involvement nodes, grade, stages GC. This retrospective...
Summary Whether cell forces or extracellular matrix (ECM) can impact genome integrity is largely unclear. Here, acute perturbations (~1hr) to actomyosin stress ECM elasticity cause rapid and reversible changes in lamin-A, DNA damage, cycle. Embryonic hearts, differentiated iPS-cells, various nonmuscle types all show that actomyosin-driven nuclear rupture causes cytoplasmic mis-localization of repair factors excess damage. Binucleation micronuclei increase as telomeres shorten, which favor...
Urea is a biomarker for diagnosis and management of multiple disorders. The measurement urea could help in the patients with kidney dysfunction. Despite their attractive analytical performances, existing methods are still limited to sophisticated time-consuming or require invasive blood sampling. Herein, reliable noninvasive, simple, disposable touch-based potentiometric sensor fabricated rapid monitoring fingertip sweat urea. Novel detection relies on immobilized urease recognition...
Current research involves preparing cerium oxide nanoparticles using simple, environmental- friendly green synthesis approach via fresh tea leaf extract (Camellia sinensis) as a capping and reducing agent, Ultraviolet-visible spectroscopy (UV-Vis.) is used to check the formation of by investigate absorption peak energy gap (Eg); Maximum was around 295nm Eg 4.2eV calculated Planck’s equation, X-Ray diffraction (XRD) analysis Nano powder stated that Cerium Oxide has cubic fluorite structure...
Zinc Oxide Nanoparticles have been prepared using a simple green synthesis method by tea extract (Camellia sinensis) as reducing and capping agent, XRD measurement of Nano powder stated that had hexagonal wurtzite structure, UV-Vis. The maximum absorption peak was approximately 318 nm the energy gap nearly 3.8eV calculated Planck’s equation, blood serum sugar levels, liver function after ZnO NPs injection for rats recorded. Forty-eight adult male were used separated randomly into six groups...
This study was conducted to evaluate the negative effects of Tamoxifen (TAM) on Testis tissues andspermatogenesis. Use for this purpose forty male mature albino rats were divided into 4 equal groups, 3groups administrated different doses (30, 40, 50) mg/kg b.w TAM 10 weeks as well controlgroup with physiological solution (normal saline 0.9%). Histopathological examination oftestes in groups showed histological changes that increased dose comparedto control group include degeneration change...
This study was conducted to investigate the adverse effect of whey protein supplement taken by athletes on some biochemical parameters which include B.urea, creatinine, uric acid and lipids profile, LDH enzyme C-reactive protein. Seventy-five Blood sample were collected from whose take supplements (experiment group), twenty five blood who don’t (control for period December 2016 June 2017. The results show a significant increase (P < 0.05) in levels acid, serum creatinine urea as compared...