A5030591278- Dermatology and Skin Diseases
- Estrogen and related hormone effects
- Heat shock proteins research
- Allergic Rhinitis and Sensitization
- T-cell and B-cell Immunology
- Immune Response and Inflammation
Northwestern University
2023-2024
Differences in prevalence of inflammatory skin diseases including atopic dermatitis and psoriasis African American (AA) versus White Non-Hispanic (WNH) population are well recognized. However, the underlying mechanisms largely unknown. We previously observed significant differences healthy AA transcriptome with differentially expressed genes (DEG) enriched for inflammation cornification processes. Here we analyzed proteome biopsies from WNH volunteers using Olink® Explore Inflammation 384...
Glucocorticoids (GCs) are widely used for the treatment of inflammatory skin diseases despite significant adverse effects including atrophy. Effects GCs mediated by glucocorticoid receptor (GR), a well-known transcription factor. Previously, we discovered that one GR target genes, REDD1, is causatively involved in Here, investigated its role function using HaCaT REDD1 knockout (KO) keratinocytes. We found large differences transcriptome KO and control Cas9 cells response to fluocinolone...