A5048697133- Nerve injury and regeneration
- Viral Infectious Diseases and Gene Expression in Insects
- Virus-based gene therapy research
- Bioactive Compounds and Antitumor Agents
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- RNA Interference and Gene Delivery
- Chemical Synthesis and Analysis
- Neurotransmitter Receptor Influence on Behavior
Tallinn University of Technology
2009-2018
Expression of brain-derived neurotrophic factor (BDNF) is induced in cultured rat cortical astrocytes by catecholamines norepinephrine and dopamine as well selective α1 β adrenergic agonists. However, it has remained unknown which receptors mediate dopamine-induced BDNF upregulation astrocytes. Here, we demonstrate that adrenoreceptors are the main mediators this effect astrocytes, while D1 contribute to a lesser extent. We show exon IV VI containing mRNAs via CREB-dependent signaling...
Abstract Background Brain-derived neurotrophic factor (BDNF) is a small secreted protein that has important roles in the developing and adult nervous system. Altered expression or changes regulation of BDNF gene have been implicated variety human system disorders. Although rodent extensively investigated, vivo studies regarding are largely limited to postmortem analysis. Bacterial artificial chromosome (BAC) transgenic mice harboring its regulatory flanking sequences constitute useful tool...
Brain derived neurotrophic factor (BDNF) belongs to a family of structurally related proteins called neurotrophins that have been shown regulate survival and growth neurons in the developing central peripheral nervous system also take part synaptic plasticity processes adulthood. Since BDNF is associated with several disorders it would be beneficial cellular reporter for studying its expression regulation. Using modified bacterial artificial chromosome (BAC), we generated transgenic cell...