A5087842522- Retinal Diseases and Treatments
- Retinal and Macular Surgery
- Retinal Development and Disorders
- Angiogenesis and VEGF in Cancer
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Retinopathy of Prematurity Studies
- Glaucoma and retinal disorders
- Lipid metabolism and disorders
- Ocular Infections and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Ocular Surface and Contact Lens
- Ocular Oncology and Treatments
- Axon Guidance and Neuronal Signaling
- Cerebrovascular and genetic disorders
- Ophthalmology and Visual Impairment Studies
- Spinal Hematomas and Complications
- Acute Ischemic Stroke Management
- Corneal surgery and disorders
- Cerebral Venous Sinus Thrombosis
- CRISPR and Genetic Engineering
- Connective tissue disorders research
- Spine and Intervertebral Disc Pathology
- Photodynamic Therapy Research Studies
- Legionella and Acanthamoeba research
Fukuoka University
2002-2021
Johns Hopkins University
2005-2009
Johns Hopkins Medicine
2005-2009
BioPredict (United States)
2008
Johns Hopkins Hospital
2008
National Eye Institute
2005-2006
In this study, we used double transgenic mice with inducible expression of angiopoietin-2 (Ang2) to investigate the role Ang2 in retinal and choroidal circulations three models ocular neovascularization (NV). Mice induced ubiquitously, or specifically retina, survived appeared grossly normal. They also had normal-appearing circulations, demonstrating that high levels did not induce regression mature vessels. When was soon after birth, there increased density deep capillary bed on postnatal...
Integrin alpha(5)beta(1) plays an important role in developmental angiogenesis, but its various types of pathologic neovascularization has not been completely defined. In this study, we found strong up-regulation choroidal neovascularization. Implantation osmotic pump delivering 1.5 or 10 microg/h ( approximately 1.8 12 mg/kg/day) 3-(2-{1-alkyl-5-[(pyridin-2-ylamino)-methyl]-pyrrolidin-3-yloxy}-acetylamino)-2-(alkylamino)-propionic acid (JSM6427), a selective antagonist, caused significant...
Age-related macular degeneration, diabetic retinopathy, and retinal vein occlusions are complicated by neovascularization edema. Multi-targeted kinase inhibitors that inhibit select growth factor receptor tyrosine kinases and/or components of their down-stream signaling cascades (such as Src kinases) rationale treatment strategies for these disease processes. We describe the discovery characterization two such agents. TG100572, which inhibits selected kinases, induced apoptosis proliferating...
Platelet-derived growth factor-B (PDGF-B) has been implicated in the pathogenesis of proliferative retinopathies and other scarring disorders eye. In this study, we sought to test therapeutic potential an aptamer that selectively binds PDGF-B, ARC126, its PEGylated derivative, ARC127. Both ARC126 ARC127 blocked PDGF-B-induced proliferation cultured fibroblasts with IC50 4 nM. Pharmacokinetic studies rabbits showed similar peak vitreous concentrations approximately 110 microM after...
Abstract Vascular endothelial growth factor (VEGF) plays a central role in vasoproliferative diseases the retina, however, other gene products modulate its effects. The angiopoietins are particularly important this regard. Angiopoietin 2 (Ang2) collaborates with VEGF to stimulate neovascularization (NV) some situations, but situations causes regression of NV. Ang2 also transient increase vascular density during retinal development. In study, we sought determine if Ang1 has similar...
Age-related macular degeneration (AMD) is one of the leading causes loss vision in industrialized world. Attenuating VEGF signal eye to treat AMD has been validated clinically. A large body evidence suggests that inhibitors targeting VEGFr pathway may be effective for treatment AMD. Recent studies using Src/YES knockout mice suggest along with VEGF, Src and YES play a crucial role vascular leak might useful treating edema associated Therefore, we have developed several potent benzotriazine...
Equine infectious anemia virus (EIAV) is a nonprimate lentivirus that does not cause human disease. Subretinal injection into mice of recombinant EIAV lentiviral vector in which lacZ driven by CMV promoter (EIAV LacZ) resulted rapid and strong expression LacZ retinal pigmented epithelial (RPE) cells some other including ganglion cells, resulting the presence 5-bromo-4-chloro-3-indolyl-β-d-galactopyranoside within optic nerve. Substitution RPE-specific from vitelliform macular dystrophy...
The tyrosine kinase receptor Tie2 and its ligands, the angiopoietins (Angs), play important roles in vascular integrity neovascularization, modulating endothelial growth factor (VEGF) activity. To elucidate potential role of Angs system retinopathy prematurity (ROP), we have investigated expression Angs, VEGF within fibroproliferative membranes ROP.Fibroproliferative were obtained from 38 cases with stage 5 ROP at time vitrectomy. Membranes fixed formalin embedded paraffin. Each specimen was...
Tumors provide an extremely abnormal microenvironment that stimulates neovascularization from surrounding vessels and causes altered gene expression within vascular cells. Up-regulation of endothelial growth factor (VEGF) receptors has allowed selective destruction tumor by administration a chimeric protein consisting VEGF<sub>121</sub> coupled to the toxin gelonin (VEGF/rGel). We sought determine whether there is sufficient up-regulation VEGF in cells participating ocular permit similar...
Vascular endothelial growth factor (VEGF) has been known as principal angiogenic in vasculogenesis, tumor angiogenesis and ocular angiogenesis. Currently, hepatocyte (HGF) reported to play a major role We studied distribution of both factors non-angiogenic fibroproliferation determine the correlation VEGF HGF retinal Concentrations molecules vitreous samples from 27 eyes with proliferative diabetic retinopathy (PDR) 9 vitreoretinopathy (PVR) were measured by enzyme-linked immunosorbent assay...
Abstract Background To evaluate the correlation between visual acuity improvement and vision-related QOL after ranibizumab treatment in Japanese patients with AMD. Methods In this one-year prospective, interventional, open-label, multicenter study involving four sites, neovascular AMD were enrolled observed for 12 months. Treatment-naïve received 0.5 mg as needed three initial monthly doses. The best corrected (BCVA) central macular thickness (CMT) measured at every visit. Evaluations...