A5070767035- Proteoglycans and glycosaminoglycans research
- Glycosylation and Glycoproteins Research
- Cell Adhesion Molecules Research
- Platelet Disorders and Treatments
- Protease and Inhibitor Mechanisms
- Angiogenesis and VEGF in Cancer
- Nitric Oxide and Endothelin Effects
- Blood Coagulation and Thrombosis Mechanisms
- Cannabis and Cannabinoid Research
- Venomous Animal Envenomation and Studies
- Biochemical and Structural Characterization
- Electrospun Nanofibers in Biomedical Applications
- Antimicrobial Peptides and Activities
- Hydrogels: synthesis, properties, applications
- Heparin-Induced Thrombocytopenia and Thrombosis
- Digestive system and related health
- NF-κB Signaling Pathways
- Seaweed-derived Bioactive Compounds
- Advanced Drug Delivery Systems
- T-cell and B-cell Immunology
- Nanoparticle-Based Drug Delivery
- Collagen: Extraction and Characterization
- Plant Toxicity and Pharmacological Properties
- Skin and Cellular Biology Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
University of Buenos Aires
2011-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2009-2024
Instituto de Química y Fisicoquímica Biológicas
2023-2024
Osaka Medical and Pharmaceutical University
2009
Rhodamine-123 (Rho-123) is a known tracer dye that can be used to analyze the efflux activity of ABC-transporter P-glycoprotein (P-gp). In addition, because Rho-123 metabolized Rho-110, then glucuronidated and transported by multidrug resistance-associated protein 2 (MRP2), could also simultaneously monitor both ABC-transporters P-gp MRP2. The blood brain barrier (BBB) expresses P-gp, MRPs breast cancer resistant (BCRP). refractory epilepsy (RE), these transporters are overexpressed in BBB...
The gold standard drug for colorectal cancer (CRC) treatment, 5-Fluorouracil (5-FU), induces pharmacological tolerance in long-term management. transcriptional factor nuclear kappa-light-chain-enhancer of activated B cells (NFκB) plays a key role 5-FU resistance. aim this work is to study the capability polyelectrolytes complex nanoparticles dermatan sulfate (DS) and chitosan (CS), loaded with anti-inflammatory tripeptide IRW, sensitize 5-FU. Fluorescence flow cytometry studies confirmed...
Decorin and biglycan proteoglycans play important roles in the organization of extracellular matrix, regulation cell adhesion migration. Given morphological functional endothelial heterogeneity, information is needed regarding whether cells (ECs) from different vascular beds possess profiles proteoglycan constituents basement membranes. Here, we report that endothelia murine organs EC lines derived thereof produce secrete patterns proteoglycans. A faint colocalization between decorin...
Summary Proteoglycan accumulation within the arterial intima has been implicated in atherosclerosis progression humans. Nevertheless, hypercholesterolaemia is unable to induce intimal thickening and atheroma plaque development rats. The study was performed analyse proteoglycans modifications rats fed with a high‐cholesterol diet understand whether vascular wall remodelling protects against lesions. Sections obtained from rat aortas showed normal features, intimal‐to‐media ratio lipid...
High levels of circulating lipoprotein constitute a risk factor for cardiovascular diseases, and in this context, the specific role very‐low‐density lipoproteins (VLDL) is poorly understood. The response human umbilical vein endothelial cells (HUVEC) to VLDL exposure was studied, especially focusing on pathways involved alteration redox homeostasis nitric oxide (NO) bioavailability. results obtained by analysis expression level genes implicated NO metabolism oxidative stress indicated strong...
A single dose of monocrotaline, a pyrrolizidine alkaloid, was injected into rats in order to produce 25 (Group I) and 45 II) days later progressive so called delayed liver injury. The present study investigated the prostanoid production Kupffer cells endothelial separated from Monocrotaline saline III) rat livers. cells: formation 6 keto Prostaglandin F1 alpha, major prostacycline metabolite, gradually decreased Groups I vs II (P < 0.01) both Controls 0.01). In addition F2 alpha showed...
Abstract Phoneutria nigriventer spider can cause severe envenomation in humans principally due to its venom toxin δ-ctenitoxin-Pn2a. Current low yielding antivenom production is extremely complicated and dangerous. Furthermore, δ-ctenitoxin-Pn2a cystine-knot motif provides exceptional stability hampering immune response activation. Here, epitopes from were identified, antigenic peptides designed for their potential use production. The Immune Epitope Database Analysis Resource was used...