A5054107714- Diabetic Foot Ulcer Assessment and Management
- Wound Healing and Treatments
- Diagnosis and Treatment of Venous Diseases
- Total Knee Arthroplasty Outcomes
- Pressure Ulcer Prevention and Management
- TGF-β signaling in diseases
- Healthcare Quality and Management
- Primary Care and Health Outcomes
- Knee injuries and reconstruction techniques
- Orthopaedic implants and arthroplasty
- Healthcare cost, quality, practices
- Cardiac, Anesthesia and Surgical Outcomes
- Shoulder Injury and Treatment
- Healthcare professionals’ stress and burnout
- Thyroid Cancer Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Migraine and Headache Studies
- Congenital heart defects research
- Cardiac Fibrosis and Remodeling
- Global Health Workforce Issues
- Infection Control and Ventilation
- Peripheral Artery Disease Management
- Bacterial Infections and Vaccines
- Maternal and Perinatal Health Interventions
- dental development and anomalies
North Cumbria Integrated Care NHS Foundation Trust
2018-2024
University of Cumbria
2010-2024
University Medical Center Utrecht
2020-2023
Cumberland Infirmary
2011-2021
University of Groningen
2020
Wilhelmina Children's Hospital
2020
Cumbria Northumberland Tyne and Wear NHS Foundation Trust
2019
Newcastle University
2004-2005
Centre for Life
2002-2004
University of the Pacific
1989
Abstract Rationale, aims and objectives Clinical research activity in hospitals is associated with reduced mortality improved overall care quality. In England, the latter a compound score of several elements both staff inpatient feedback form part Care Quality Commission (CQC) ratings. The objective this study was to determine if NHS Trusts' National Institute for Health Research (NIHR) data correlates specific outcomes from national patient surveys. Method Retrospective cohort design...
Hereditary haemorrhagic telangiectasia (HHT) is an autosomal dominant disorder in humans that characterised by multisystemic vascular dyplasia and recurrent haemorrhage. Germline mutations one of two different genes, endoglin or ALK1 can cause HHT. Both are members the transforming growth factor (TGF) beta receptor family proteins, expressed primarily on surface endothelial cells (ECs). Mice lack activin like kinase (ALK) 1 die at mid-gestation as a result defects yolk sac vasculature. Here,...
The practise of Immediate Breast Reconstruction (IBR) following mastectomy for primary breast cancer is being increasingly adopted. Here the impact IBR on disease progression and survival was assessed treatment invasive cancer. 1697 consecutive patients received surgical operable between January 1996 December 2007. Overall, 691 (41%) whom 136 (20%) underwent (82 Latissimus Dorsi, 54 Subpectoral). effect overall survival, local distant recurrence analysed in all studied also separately within...
Objective To determine knowledge levels, and attitudes perceptions towards, menopause among highly educated Asian women in their midlife. Study design A cross-sectional survey. Setting Five teaching institutions Hyderabad, Pakistan. Population In total, 200 out of 225 (89% response rate) teachers, lecturers professors, aged 40–59 years, were surveyed 2013 using a self-administered questionnaire. Results The mean age responders was 48 years. Premenopausal perimenopausal attributed for 58%,...
Objective: Transforming growth factor beta (TGFβ)-activated kinase 1 (TAK1) is a MAP involved in numerous signalling pathways and strongly implicated cardiac hypertrophy heart failure. TGFβ also associated with hypertension disease, evidence suggests that TGFβ1 TAK1 act together stress pathway. Canonical mediated through Smad transcription factors, but can rapidly activate TAK1. The activation of the cascade well characterised, little known about how activated response to TGFβ, no direct...
Indirect magnetic resonance arthrography (I-MRA) confers significant logistical advantages over direct MRA and does not require articular injection. In this study, we determined the diagnostic performance of I-MRA in relation to conventional MRI arthroscopy or surgery detecting tears glenoid labrum, including Bankart lesions superior labral antero-posterior (SLAP) a standard clinical setting.Ninety-one symptomatic patients underwent affected shoulder, followed by either open surgery. The...
Abstract Introduction Our aim was to gain insight into the effect of COVID-19 measures on SARS-CoV-2 incidence in secondary schools and association with classroom CO 2 concentration airborne contamination. Methods Between October 2020—June 2021, 18 weekly reported completed surveys school-initiated (e.g. improving hygiene or minimizing contacts). measured occupied classrooms twice, air contamination longitudinally using electrostatic dust collectors (EDC) analyzed RT-qPCR. National policy...
Abstract Background The National Institute for Health and Care Research (NIHR) was set up to enhance clinical health research activity in a variety of Service (NHS) healthcare settings, including primary care. Objective To appraise how overall General Practitioner (GP) practice performance, location, staffing levels may interact with NIHR Portfolio care England. Methods Cross-sectional summary GP descriptors; complete data from 6,171 practices collated (using 2013–2023 studies), Public...
In this retrospective cohort study involving 393 singleton pregnancies, we evaluated the maternal and prenatal factors influencing use of outcome prostaglandin E(2) (PGE(2)) induced labours. Only a nulliparous pregnancy was shown to be significant predictor more than one dose PGE(2) (odds ratio, OR 2.73, 95% confidence interval, CI 1.61-4.63). When type delivery assessed, status significantly associated with decreased chance vaginal (OR 0.12, 0.045-0.32). Other variables that positively...
The choice & decision-making powers around contraception and family planning in relation to educational levels women from a developing country, was explored this explorative knowledge, attitude practice study.A survey collated data 324 married of reproductive age.A mixture urban rural, lower higher educated participated.Sixty percent indicated that they had not been given regarding size; unwanted pregnancies are common occurrence.Although woman's level education has positive impact -as group...