A5056119350- Anaerobic Digestion and Biogas Production
- Microtubule and mitosis dynamics
- Advanced Proteomics Techniques and Applications
- Genomics and Phylogenetic Studies
- Genetic and Kidney Cyst Diseases
- Protein Degradation and Inhibitors
- Advanced Biosensing Techniques and Applications
- Amyotrophic Lateral Sclerosis Research
- Biofuel production and bioconversion
Technical University of Munich
2021-2023
German Cancer Research Center
2023
Heidelberg University
2023
DKFZ-ZMBH Alliance
2023
The NEK1 kinase controls ciliogenesis, mitosis, and DNA repair, mutations cause human diseases including axial spondylometaphyseal dysplasia amyotrophic lateral sclerosis. C21ORF2 a similar pattern of diseases, suggesting close functional links with . Here, we report that endogenous form tight complex in cells. A interaction domain “CID” at the C-terminus is necessary for its association cells, pathogenic this region disrupt complex. AlphaFold modelling predicts an extended binding interface...
Abstract Kinase inhibitors (KIs) are important cancer drugs but often feature polypharmacology that is molecularly not understood. This disconnect particularly apparent in entities such as sarcomas for which the oncogenic drivers clear. To investigate more systematically how cellular proteotypes of sarcoma cells shape their response to targeted drugs, we profiled proteomes and phosphoproteomes 17 cell lines screened same against 150 drugs. The resulting 2550 phenotypic profiles revealed...
Strain MD1T is an anaerobic, Gram-stain-negative bacterium isolated from a lab-scale biogas fermenter fed with maize silage. It has rod-shaped morphology peritrichously arranged appendages and forms long chains of cells coccoid structures. The colonies were white, circular, slightly convex had smooth rim. isolate mesophilic, displaying growth between 25 45 °C optimum at 40 °C. grew pH values 6.7-8.2 (optimum, 7.1) tolerated the addition up to 1.5% (w/v) NaCl medium. main cellular fatty acids...