A5046569396- Amyotrophic Lateral Sclerosis Research
- Microtubule and mitosis dynamics
- Protein Degradation and Inhibitors
- Chromatin Remodeling and Cancer
- RNA Research and Splicing
- Peptidase Inhibition and Analysis
- Genetic and Kidney Cyst Diseases
University of Toronto
2022-2024
Mount Sinai Hospital
2022-2024
Lunenfeld-Tanenbaum Research Institute
2022-2024
The NEK1 kinase controls ciliogenesis, mitosis, and DNA repair, mutations cause human diseases including axial spondylometaphyseal dysplasia amyotrophic lateral sclerosis. C21ORF2 a similar pattern of diseases, suggesting close functional links with . Here, we report that endogenous form tight complex in cells. A interaction domain “CID” at the C-terminus is necessary for its association cells, pathogenic this region disrupt complex. AlphaFold modelling predicts an extended binding interface...
Abstract NEK1 is a pleiotropic protein kinase implicated in mitosis, ciliogenesis and DNA repair but little known about its regulation or targets. Its relevance for human health underscored by the association of mutations with diseases including axial spondylometaphyseal dyplasia (SMD) amyotrophic lateral sclerosis (ALS). Mutations C21ORF2 gene are associated similar pattern diseases, suggesting close functional links . Here we report that unperturbed, untransformed cells, endogenous form...