A5102861575- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Zebrafish Biomedical Research Applications
- Histone Deacetylase Inhibitors Research
- Neurogenesis and neuroplasticity mechanisms
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Viral Infections and Immunology Research
- Advanced Fluorescence Microscopy Techniques
Technical University of Munich
2021-2022
Ludwig-Maximilians-Universität München
2021-2022
University of Tübingen
2018-2020
Democritus University of Thrace
2014
Abstract Cone photoreceptor cell death in inherited retinal diseases, such as Retinitis Pigmentosa (RP), leads to the loss of high acuity and color vision and, ultimately blindness. In RP, a vast number mutations perturb structure function rod photoreceptors, while cones remain initially unaffected. Extensive advanced stages disease triggers cone by mechanism that is still largely unknown. Here, we show secondary animal models for RP associated with increased activity histone deacetylates...
Neuronal identity has long been thought of as immutable, so that once a cell acquires specific fate, it is maintained for life.1 Studies using the overexpression potent transcription factors to experimentally reprogram neuronal fate in mouse neocortex2,3 and retina4,5 have challenged this notion by revealing post-mitotic neurons can switch their identity. Whether reprogramming part normal development central nervous system (CNS) unclear. While there are some reports physiological...
Abstract Cone photoreceptor cell death in inherited retinal diseases, such as Retinitis Pigmentosa (RP), leads to the loss of high acuity and color vision ultimately blindness. In RP, a vast number mutations perturb structure function rod photoreceptors while cones remain initially unaffected. follows secondarily due increased oxidative stress, inflammation, structural nutritional support provided by rods. Here, we show that secondary cone animal models for RP was associated with an activity...