A5041275640- Nerve injury and regeneration
- Pain Mechanisms and Treatments
- Spinal Cord Injury Research
- Nerve Injury and Rehabilitation
- Neurogenesis and neuroplasticity mechanisms
- Botulinum Toxin and Related Neurological Disorders
- Mesenchymal stem cell research
- Pain Management and Treatment
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Anesthesia and Pain Management
- Musculoskeletal pain and rehabilitation
- Anesthesia and Neurotoxicity Research
- Neuropeptides and Animal Physiology
- Pediatric Pain Management Techniques
- Pain Management and Placebo Effect
- Peripheral Nerve Disorders
- Muscle activation and electromyography studies
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects of Natural Compounds
- Neuroinflammation and Neurodegeneration Mechanisms
- Cerebral Palsy and Movement Disorders
- Cancer Treatment and Pharmacology
- Healthcare and Venom Research
- Pain Management and Opioid Use
RWTH Aachen University
2008-2019
UCLouvain
2012-2019
Universitätsklinikum Aachen
2008-2019
Cliniques Universitaires Saint-Luc
2013-2016
Brain (Germany)
2012-2014
Jülich Aachen Research Alliance
2012-2014
University of California, San Diego
2010-2013
National Institutes of Health
2013
Kafkas University
2013
Royal College of Anaesthetists
2013
The Basso, Beattie and Bresnahan (BBB) locomotor rating scale is the most widely used open field test has been accepted as a valid way to assess function after spinal cord contusion injury in rat. A limitation within BBB correct assessment of forelimb (FL)-hindlimb (HL) coordination. This can have major implications for final function. In present study, we show an objective method coordination based on regularity index (RI), achieved through use CatWalk method. RI grades degree result number...
We systematically investigated a series of polymers derived from macrolactones, namely, pentadecalactone, hexadecalactone, and their unsaturated analogues ambrettolide globalide as potential biomaterials. By enzymatic ring-opening polymerization these monomers can conveniently be polymerized to high molecular weight. The are highly crystalline with melting points around 95 °C for the saturated lower (46−55 °C). All nontoxic measured by an MTT assay metabolic cell activity 3T3 mouse...
Chronic pain associated with inflammation is a common clinical problem, and the underlying mechanisms have only begun to be unraveled. GRK2 regulates cellular signaling by promoting G-protein-coupled receptor (GPCR) desensitization direct interaction downstream kinases including p38. The aim of this study was determine contribution regulation inflammatory unravel mechanism. +/− mice an ∼50% reduction in developed increased markedly prolonged thermal hyperalgesia mechanical allodynia after...
Traumatic injury to the nervous system induces functional deficits as a result of axonal destruction and formation scar tissue, cystic cavitation, physical gaps. Bioengineering bridging materials should ideally act cell carriers for implantation axon growth-promoting glia, well supporting integration with host types. Here, we describe cytocompatibility novel, micro-structured porcine collagen scaffold containing densely packed highly orientated channels that, in three-dimensional (3D) tissue...
Systemic ketamine can trigger apoptosis in the brain of rodents and primates during susceptible developmental periods. Clinically, spinally administered may improve duration or quality analgesia children. Ketamine-induced spinal cord toxicity has been reported adult animals but not systematically studied early development.In anesthetized rat pups, intrathecal was by lumbar percutaneous injection. Changes mechanical withdrawal threshold evaluated dose-dependent antinociceptive...
The enzymatic synthesis of a series random copolyesters by ring-opening polymerization unsaturated macrolactones like globalide and ambrettolide with 1,5-dioxepan-2-one (DXO) 4-methyl caprolactone (4MeCL) was investigated. 13C NMR diad analysis confirmed the randomness all copolymers irrespective comonomer ratios. Thermal investigation showed that incorporating comonomers lowered melting points polymers as compared macrolactone homopolymers. decrease dependent on ratio. were thermally...
Abstract Background Neuroinflammation and nitroxidative stress are implicated in the pathophysiology of neuropathic pain. In view both processes, microglial astroglial activation spinal dorsal horn play a predominant role. The present study investigated severity pain degree glial an inflammatory- nitroxidative-prone animal model. Methods Transgenic rats expressing mutated superoxide dismutase 1 (hSOD1 G93A ) classically used as model for amyotrophic lateral sclerosis (ALS). Because...
Stem cells of the apical papilla (SCAP) represent great promise regarding treatment neural tissue damage, such as spinal cord injury (SCI). They derive from crest, express numerous neurogenic markers, and mediate neurite outgrowth axonal targeting. The goal present work was to investigate for first time their potential promote motor recovery after SCI in a rat hemisection model when delivered original stem cell niche—that is, by transplantation human itself into lesion. Control groups...
Multipotent mesenchymal stem (stromal) cells (MSCs) have been credited with immunomodulative properties, supporting beneficial outcomes when transplanted into a variety of disease models involving inflammation. Potential mechanisms include the secretion paracrine factors and establishment neurotrophic microenvironment. To test hypothesis that MSCs release soluble mediators can attenuate local inflammation, we here analysed influence on activation microglia cells, as well inflammatory...