A5068258611- Enzyme Production and Characterization
- Biofuel production and bioconversion
- DNA Repair Mechanisms
- Enzyme Catalysis and Immobilization
- Mitochondrial Function and Pathology
- Metal complexes synthesis and properties
- Molecular Sensors and Ion Detection
- Metabolism and Genetic Disorders
- Bone Tissue Engineering Materials
- Electrochemical Analysis and Applications
- Microbial Metabolic Engineering and Bioproduction
- Luminescence and Fluorescent Materials
- Advanced Chemical Sensor Technologies
- Genomics and Chromatin Dynamics
- Virus-based gene therapy research
- Electrochemical sensors and biosensors
- RNA Interference and Gene Delivery
- RNA and protein synthesis mechanisms
- Corrosion Behavior and Inhibition
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Peptidase Inhibition and Analysis
- Advanced biosensing and bioanalysis techniques
- Additive Manufacturing and 3D Printing Technologies
- Animal Genetics and Reproduction
National Institute of Technology Durgapur
2015-2025
The University of Texas MD Anderson Cancer Center
2007-2009
Pediatrics and Genetics
2006
Baylor College of Medicine
2001-2002
Bose Institute
2000
Development of suitable materials that acts as an interface between the implant and tissues in body system structurally, mechanically bio functionally is important for success tissue engineering.This motivated scientists biologists to find out bioactive aforementioned purpose.There has been growing interest developing synthetic ceramics could closely mimic natural apatite characteristics.Hydroxyapatite (HAp) widely used a biocompatible ceramic but mainly contact with bone tissue, due its...
Cells from patients with Fanconi anemia (FA), an inherited disorder that includes bone marrow failure and cancer predisposition, have increased sensitivity to oxidative stress through unknown mechanism. We demonstrate the FA group G (FANCG) protein is found in mitochondria. Wild-type but not G546R mutant FANCG physically interacts mitochondrial peroxidase peroxiredoxin-3 (PRDX3). PRDX3 deregulated cells, including cleavage by a calpainlike cysteine protease mislocalization. FA-G cells...
The distal region (−830 to −720 bp) of the rat whey acidic protein (WAP) gene contains a composite response element (CoRE), which has been demonstrated previously confer mammary gland-specific and hormonally regulated WAP expression. Point mutations in binding sites for specific transcription factors present within this CoRE have importance both nuclear factor I (NFI) STAT5 as well cooperative interactions with glucocorticoid receptor (GR) regulation expression gland transgenic mice. This...
A urea-based molecule behaving as a ditopic sensor for fluoride and cadmium.
ABSTRACT Disulfide bonds are important for maintaining the structural conformation and stability of protein. The introduction disulfide bond is a promising strategy to increase thermostability In this report, cysteine residues introduced form in Glycoside Hydrolase family GH 7 cellobiohydrolase (GH7 CBHs) or Cel7A Aspergillus fumigatus . by Design 2.0 (DbD2), an online tool used detection mutation sites. Mutations created (D276C-G279C; DSB1, D322C-G327C; DSB2, T416C-I432C; DSB3, G460C-S465C;...
To study the role of glucocorticoid receptor (GR) at different stages mammary gland development, anlage were rescued from GR-/- mice by transplantation into cleared fat pad wild-type mice. In virgin mice, outgrowths displayed abnormal ductal morphogenesis characterized distended lumena, multiple layers luminal epithelial cells in some regions along ducts, and increased periductal stroma. contrast, loss GR did not result overt phenotypic changes development during pregnancy, lactation,...
Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS) are progressive neurodegenerative diseases that affect the neurons in brain spinal cord. Neuroinflamation apoptosis key players damage of AD ALS. Currently, there is no drug to offer complete cure for both these diseases. Riluzole only available can prolong life time ALS patients nearly 3 months. Molecules good HIT molecular targets will help treat patients. P53 kinase receptor (4AT3), EphA4 (3CKH) histone deacetylase (3SFF)...
Kinetics of the interaction between [Pt(pic)(H<sub>2</sub>O)<sub>2</sub>](ClO<sub>4</sub>)<sub>2</sub>and selected thiols has been studied in aqueous medium as a function [complex], [thiol], pH and temperature at constant ionic strength.
Previously, we have shown that SNM1A is a multifunctional gene involved in both the DNA damage response and an early mitotic checkpoint to spindle stress. Another member of SNM1 family, SNM1B/Apollo, has been roles interstrand cross-linking agents telomere protection during S phase. Here, demonstrate novel role for SNM1B/Apollo mitosis SNM1B-deficient cells exhibit defect prophase checkpoint. Loss induces extended delay, which due prolonged activation In addition, show interacts with...
Abstract Cheap production of glucose is the current challenge for cheap bioethanol. Ideal protein engineering approaches are required improving efficiency members cellulase, enzyme complex involved in saccharification process cellulose. An attempt was made to improve cellobiohydrolase (Cel6A), important member cellulase isolated from Aspergillus fumigatus (AfCel6A). Structure-based variants AfCel6A were designed. Amino acids surrounding catalytic site and conserved residues cellulose-binding...
l-2-Hydroxy acid oxidase (Hao2) is a peroxisomal enzyme with predominant expression in the liver and kidney. Hao2 was recently identified as candidate gene for blood pressure quantitative trait locus rats. To investigate pharmacological role of management pressure, selective inhibitors were developed. Optimization screening hits 1 2 led to discovery compounds 3 4 potent rat pharmacokinetic properties suitable vivo studies Treatment compound or resulted significant reduction attenuation an...
Global demand for bioethanol is increasing tremendously as it could help to replace the conventional fossil fuel and at same time supporting bioremediation of huge volume cellulosic wastes generated from different sources. Ideal genetic engineering approaches are essential improve efficacy production processes real applications. A locally isolated fungal strain Aspergillus fumigatus NITDGPKA3 was used in our laboratory hydrolysis lignocellulose with good cellulolytic activity when compared...
Abstract Rhodamine‐formylaniline conjugate RFA has been developed as a Cu 2+ ‐selective ratiometric fluorescent probe. The probe shows high selectivity towards ion through both its absorption and emission properties; characterized by 1 H NMR, FTIR, ESI‐MS spectroscopy. Sensing of proceed FRET process which is nicely depicted from steady‐state fluorescence lifetime studies. From the measurement lifetime, mechanism established undoubtedly. important parameters regarding FRET, namely energy...
Third order kinetics of bio-relevant thiols and thio-ether with dinuclear Pd(<sc>ii</sc>) complex possessing anticancer antibacterial properties.
The present study focuses on the application of central composite design response surface methodology for optimisation process parameters to develop a hybrid mechanically stable biocompatible porous scaffold. scaffolds are developed by varying composition fish scale derived HAp and nanocrystalline TiO2 powders. effects sintering temperature, dwell time porosity compressive strength investigated. Various diagnostic tools (e.g. thermogravimetric/differential thermal analysis, Fourier transform...
The oxidation of [RuII(tpy)(pic)H2O]+ (tpy = 2,2′,6′,2′′-terpyridine; pic− picolinate) by peroxidisulfate (S2O82−) as precursor oxidant has been investigated kinetically UV-VIS, IR and EPR spectroscopy. overall Ru(II)- to Ru(IV)-species takes place in a consecutive manner involving [RuIII(tpy)(pic)(OH)]+, its further the ultimate product [RuIV(tpy)(pic)(O)]+ complex. time course reaction was followed function [S2O82−], ionic strength (I) temperature. Kinetic data activation parameters are...