A5091270891- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Ferroptosis and cancer prognosis
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Robot Manipulation and Learning
- Medical Research and Treatments
- RNA Research and Splicing
- Lung Cancer Diagnosis and Treatment
- Robotic Mechanisms and Dynamics
- Multiple and Secondary Primary Cancers
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Inflammatory Biomarkers in Disease Prognosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Immunotherapy and Immune Responses
- Synthesis and biological activity
- Peptidase Inhibition and Analysis
- Colorectal Cancer Treatments and Studies
- Prosthetics and Rehabilitation Robotics
- Cholangiocarcinoma and Gallbladder Cancer Studies
Shandong First Medical University
2018-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Shandong Tumor Hospital
2020-2022
Xinjiang Medical University
2020-2021
Tumor Hospital of Xinjiang Medical University
2020-2021
South China Agricultural University
2018
University of Jinan
2018
Background Accumulating evidence indicates that the B cells play important roles in anti-tumor immunity and shaping tumor development. This study aimed to explore expression profiles of cell marker genes construct a cell-related gene pairs (BRGPs) signature associated with prognosis immunotherapeutic efficiency non-small lung cancer (NSCLC) patients. Methods NSCLC were identified using single-cell RNA sequencing data. TCGA GEO datasets utilized identify prognostic BRGPs based on novel...
Immune related interferon regulatory factor 4 (IRF4) is a member of the IRF family, whereas clinical significance and possible role IRF4 in lung adenocarcinoma (LUAD) remains unclear. We aimed to investigate predicting prognosis LUAD patients.Using The Cancer Genome Atlas (TCGA) database our immunohistochemical (IHC) cohort, we analyzed correlation between expression characteristics, prognostic value was also evaluated LUAD. potential biological functions were by Gene Set Enrichment Analysis...
Fault tolerance is important for a redundant robot manipulator, which endows the with capability of finishing end-effector task even when one or some joints' motion fails. In this paper, varying-parameter neural control architecture designed to achieve fault manipulators. Specifically, quadratic programming (QP)-based fault-tolerant planning scheme formulated. Second, varying parameter recurrent network (VP-RNN) proposed resolve standard QP problem, can make remaining healthy joints remedy...
e21032 Background: Previous studies suggested that MET exon 14 ( METex14) mutation regarding as a distinct subset was sensitive to MET-inhibitors, but poorly response immunotherapy. Conversly, non-exon-14 (non-ex14) mutations including those undetermined functions and affecting the kinase or extracellular domains were found be associated with resistance MET-inhibitors. However, therapeutic strategies for MET-non-ex14 mutant cancer are still largely unknown, relationship between efficacy of...
e21667 Background: Previous studies suggested that the efficacy of osimertinib was better in patients with epidermal growth factor receptor ( EGFR) exon 19 deletion (ex19del) than 21 Leu858Arg (L858R). However, differential clinical outcomes previous tyrosine kinase inhibitors (TKIs) treated non-small-cell lung cancer (NSCLC) brain metastases (BrMs) according to two different common EGFR genotypes remains undetermined. Methods: We retrospectively collected mutant (ex19del and L858R) NSCLC...
e21051 Background: Tumor-infiltrating B cells accompanying several widely used cell-related biomarkers, such as CD19 and CD20, have inconsistent clinical prognostic values in non-small-cell lung cancer (NSCLC) patients. Considering only one biomarker could not distinguish the anti-tumor pro-tumor cell subsets tumor, we aimed to construct a more accurate B-cells related gene pairs (BRGPs) model evaluate its potential predictive ability immunotherapy NSCLC Methods: Using public single-cell RNA...
e21055 Background: PD-L1 is a recommended biomarker for immunotherapy, but Some patients with high pD-L1 expression had poor clinical response. Considering the inconsistent correlation between PD- L1 and ICI efficacy, A more sensitive needed to predict immunotherapy efficacy. B-cell lymphoma-2 (BCL2L11/BIM) belongs Bcl-2 family key factor promoting apoptosis. BIM deletion polymorphism (BIM- del) may lead BH3 thus hinder cell Loss decreased of resistance tumor therapy. study on metastatic...
e14561 Background: Cancer patients with immune checkpoint inhibitors (ICIs) treatment often experience unique progression response patterns, accounting for the discordance of short-term and long-term benefits. Identifying specific characteristics different quality disease (PD) events can maximize curative effect ICIs further improve prognosis immunotherapy. In this study, we established a neutrophil-to-lymphocyte ratio (NLR)-based nomogram model which could predict survival NSCLC primary...
Abstract Background: Exportin 1 (XPO1) plays an important role in the maintenance of cellular homeostasis. However, clinical implications XPO1 alterations non-small-cell lung cancer (NSCLC) patients are still unclear. Methods: We collected 5792 samples and 5644 with both mutation CNA data from cBioPortal database. The potential relationship between survival NSCLC was evaluated. Besides, we analyzed tumor infiltration immune cells harboring by TIMER Results: total incidence 2.8 % (158/5644)...
e20519 Background: Immune checkpoint inhibitors have revolutionized the patterns of tumor treatment with significantly improved survival. However, it’s worth noting that objective response rate PD-1/PD-L1 monotherapy is just 20% in non-small cell lung cancer (NSCLC) patients, and biomarkers for prognosis patients receiving are urgently needed. LILRB2 (ILT4) known as an immunosuppressive molecule promotes development progression NSCLC. relationship between expression immune microenvironment...