A5047904573- biodegradable polymer synthesis and properties
- Advanced Polymer Synthesis and Characterization
- Hydrogels: synthesis, properties, applications
- Carbon dioxide utilization in catalysis
- Polymer Surface Interaction Studies
- Nanoparticle-Based Drug Delivery
- Inorganic Fluorides and Related Compounds
- Luminescence and Fluorescent Materials
- Nanoplatforms for cancer theranostics
- Supramolecular Self-Assembly in Materials
- Systemic Lupus Erythematosus Research
- Advancements in Transdermal Drug Delivery
- Silicone and Siloxane Chemistry
- Surfactants and Colloidal Systems
- Polymer crystallization and properties
- Cardiac Valve Diseases and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Additive Manufacturing and 3D Printing Technologies
- Curcumin's Biomedical Applications
- Orthopaedic implants and arthroplasty
- Ocular Diseases and Behçet’s Syndrome
- Nuclear Materials and Properties
- Rare-earth and actinide compounds
- Aortic Disease and Treatment Approaches
- High-pressure geophysics and materials
Sichuan University
2018-2019
Chengdu University
2018-2019
Shenyang Normal University
2018
Université de Montpellier
2013-2015
Centre National de la Recherche Scientifique
2013-2015
Institut des Biomolécules Max Mousseron
2013-2015
Fudan University
2006-2011
Intelligent polymeric micelles have been developed as potential nanoplatforms for efficient drug delivery and diagnosis. Herein, we successfully prepared redox-sensitive combined aggregation-induced emission (AIE) imaging an outstanding anticancer carrier system simultaneous chemotherapy bioimaging. The amphiphilic copolymer TPE-SS-PLAsp-b-PMPC could self-assemble into spherical micelles, these biomimetic exhibited great biocompatibility remarkable ability in antiprotein adsorption, showing...
Abstract A series of biodegradable chitosan‐ graft ‐polylactide (CS‐ g ‐PLA) copolymers were prepared by grafting poly( L ‐lactide) (PLLA) or D (PDLA) precursor to the backbone chitosan using N , ′‐carbonyldiimidazole as coupling agent. The composition was varied adjusting chain length PLA well ratio PLA. synthesized via this ‘graft‐onto’ method present interesting properties shown NMR and infrared spectroscopy, gel permeation chromatography solubility tests. Hydrogels mixing water‐soluble...
ABSTRACT Novel thermo‐responsive poly( N ‐isopropylacrylamide)‐ block ‐poly( l ‐lactide)‐ ‐isopropylacylamide) (PNIPAAm‐ b ‐PLLA‐ ‐PNIPAAm) triblock copolymers were successfully prepared by atom transfer radical polymerization of NIPAAm with Br‐PLLA‐Br macroinitiator, using a CuCl/tris(2‐dimethylaminoethyl) amine (Me 6 TREN) complex as catalyst at 25 °C in , ‐dimethylformamide/water mixture. The molecular weight the ranges from 18,000 to 38,000 g mol −1 and dispersity 1.10 1.28. Micelles are...
Thermo-responsive P(NIPAAm-<italic>co</italic>-DMAAm)-<italic>b</italic>-PLLA-<italic>b</italic>-P(NIPAAm-<italic>co</italic>-DMAAm) triblock copolymers are synthesized <italic>via</italic> combination of ring-opening polymerization and atom transfer radical polymerization.
The thermo-sensitive hydrogels with high drug loading rate achieved sustained release over 2 weeks. Histopathological examination of retina confirmed the excellent biocompatibility and effective anti-inflammatory property hydrogel.
Abstract A series of copolymers have been synthesized by the ring‐opening polymerization glycolide, L ‐lactide, and ϵ‐caprolactone with zirconium(IV) acetylacetonate [Zr(Acac) 4 ] or stannous octoate [Sn(Oct) 2 as catalyst. The resulting terpolymers characterized analytical techniques such proton nuclear magnetic resonance, size exclusion chromatography, differential scanning calorimetry. Data confirmed that Sn(Oct) leads to less transesterification polymer chains than Zr(Acac) under similar...
Thermal-induced micelles prepared with P(NIPAAm-<italic>co</italic>-TPE)-<italic>b</italic>-POEGMA double hydrophilic block copolymers for drug release. Hydrogen bonds are formed between PNIPAAm and thymopentin.
This work aims to evaluate the cytocompatibility and hemocompatibility of thermo‐responsive polymers as potential drug carrier. Thermo‐responsive poly( N ‐isopropyl acrylamide) (PNIPAAm) acrylamide)‐poly( l ‐lactide)‐poly( (PNIPAAm‐PLLA‐PNIPAAm) triblock copolymer were synthesized by atom transfer radical polymerization using ethyl α ‐bromoisobutyrate or Br‐PLLA‐Br initiator under mild conditions. The self‐assembly properties in aqueous medium investigated critical micelle concentration,...
Abstract A series of terpolymers obtained from glycolide/ L ‐lactide/ε‐caprolactone were compression molded and allowed to degrade in a pH 7.4 phosphate buffer at 37°C. Analytical techniques such as 1 H‐NMR, DSC, ESEM SEC used monitor the degradation. Heterogeneous degradation was observed due internal autocatalysis carboxylic endgroups formed by ester bond cleavage. Nevertheless, copolymers present various behaviors depending on initial composition. The PCL component appears most resistant...
Abstract Atom transfer radical polymerization (ATRP) is one of the most powerful methodologies for polymerization. Well‐controlled ATRP N ‐isopropylacrylamide (NIPAAm) could be obtained in organic‐water mixture solvent with conventional metal catalyst/ligand catalyst system. However, not suitable copolymerization NIPAAm hydrophobic monomers. Moreover, further purification was required biomedical Here, poly( ‐isopropylacrylamide) (PNIPAAm) synthesized by visible light–induced metal‐free using...
Amphiphilic chitosan-graft-polylactide copolymers (CS-g-PLA) were synthesized via coupling reaction of monocarboxyl-ended polylactide with the amine group chitosan in presence 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and N-hydroxysuccinimide. The composition CS-g-PLA was confirmed by 1H NMR FTIR. Self-assembled micelles prepared direct dissolution aqueous medium. TEM DLS used to determine morphology size distribution micelles. average diameter determined range 100-120nm,...
The phase stability and elastic property of ϵ-Pu at 800 K are predicted through systematically theoretical calculations, by taking the temperature-dependent phonon smearing, spin fluctuation, vibration, volume expansion effects into account. Dominated smearing K, is thermodynamically stabilized in paramagnetic state with absolute value local magnetic moment (μPu) about 3.8 μB, being smaller than 0 (about 5.0 μB). resulted thermal which prefers δ−ϵ transition, greatly decreases (V) shear...